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Medication Description: Instenon (Instenon)

INSTENON (Instenon) * (The name of the drug company "Hafslund

Nycomed Pharma AG ".).

The combined preparation containing three separate medicinal substances: hexobendin, etamivan and etofillin.

Hexobendin (Hexobendin).

Synonyms: Ditrimin, Dilancor, Ditrimin, Hexabendin, Ustimon.

It has spasmolytic and vasodilating activity. Moderately dilates coronary vessels. Previously (under the name "Ditrimin") was used as an antianginal agent, but in this respect it is inferior to modern antianginal drugs.

The drug somewhat increases cerebral circulation and improves metabolic processes in the brain, which is the basis for its inclusion in the composition of instenon.

Etimivan (Etamivan).

N, N-diethylamide vanillic acid.

Synonyms: Analticticon, Caddiovanil, Сorvanil, Emivan, Romecor, Sevanil, Vandid, Véniton and others.

On chemical structure and pharmacological action is close to cordiamine (see). Is analeptic. Stimulates the central nervous system, stimulates the respiratory and vasomotor centers.

Etophylline (Etofilline).

Hydroxyethyl teofillin.

Synonyms: Aethorhullin, Soporhyllin N, Sordalin, Ohurhyllin, Soluphyllin, Theostat, Theohullin, etc.

On the structure and pharmacological properties similar to theophylline and diprofillin (see). It improves cerebral circulation, stimulates the vasomotor center, has a positive inotropic effect on the heart; also has a bronchodilator and moderate diuretic activity.

The combination of these three substances justifies the use of instenon to improve brain function in conditions of impaired blood flow, ischemia and hypoxia.

The drug is proposed for use in ischemic stroke, residual effects after a stroke, dyscirculatory encephalopathy, post-traumatic encephalopathy, vascular dystonia and other manifestations of cerebrovascular insufficiency.

Instenon is administered orally, intravenously and intramuscularly.

Inside take mainly in chronic forms of cerebrovascular insufficiency, 1 pill of instenon forte or 2 pills of instenon 2 to 3 times a day for 3 to 4 weeks.

Intravenous (or intramuscularly) prescribe instenon mainly in acute forms of cerebral ischemia and hypoxia. Enter 1 ml (1 ampoule) 1 2 - 3 times a day for 3 - 5 days or until the onset of clinical improvement. Intravenous administration is performed slowly (drip). The contents of the ampoule is diluted in 200 ml of 5% glucose solution or isotonic sodium chloride solution. With rapid intravenous administration may develop tachycardia, the appearance of headache, facial hyperemia.

The use of instenon is contraindicated with increased intracranial pressure, intracerebral hemorrhages, epilepsy.

Forms of release: drops, containing 20 mg of hexobandin, 50 mg of etamivan and 60 mg of etofillin; dragee forte, containing 60 mg of hexobandin, 100 mg of etamivan and 60 mg of etofillin; in ampoules containing 10 mg hexobendin, 50 mg etamivan and 100 mg etofillin.