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Description medications: Molsidomine (Molsidominum)

Molsidomine (Molsidominum) *.

Ethyl N-carboxy-3-morpholino-sydnonimine.

Synonyms: Korvaton, Sydnopharm, Corvaton, Molsidomin, Morial, Motazomin , Sydnopharm.

White kristallichessky powder.

On chemical structure molsidomine has similarities with psychotropic drugs Sidnokarb (cm.) And sidnofenom (cm.). Psychotropic activity, however it does not have, as an active peripheral vasodilator. It lowers the tone of peripheral capacitance vessels (venules), and venous flow to the heart. Under the influence of molsidomine lowered pulmonary artery pressures, decreased left ventricular filling and myocardial wall stress, and stroke volume. The preparation enhances collateral blood flow, reduces platelet aggregation.

Molsidomine vasodilatory action, probably to some extent due to the presence in its molecule NO group that unites it with the nitrite and sodium nitroprusside (cm.).

Apply molsidomine primarily as antianginal agent for the prevention of strokes. In these cases it is taken orally (in the form of 2 mg tablets). The action is similar to the action mostly nitrates. Compared with nitrosorbidom, the effect comes a little earlier, but the total duration of action is somewhat less.

For relief of angina is sometimes administered sublingually molsidomine.

When applying molsidomine in the treatment of pulmonary-cardiac insufficiency can be achieved reducing pulmonary hypertension and hemodynamic improvement.

Molsidomine Inside take 1 - 2 mg (2.1 - 1 tablet) 2 - 3 4 times a day after meals.

Sublingually administered by 1/2 - 1 tablet.

With sublingual application of effect occurs within 5 - 10 minutes, at intake - 20 minutes.

For molsidomine compared with organic nitrates less tolerance develops.

Before the drug can headache and a slight decrease in blood pressure, passing in dose reduction. Some patients molsidomine is better tolerated than the nitrates.

Contraindications: cardiogenic shock and severe hypotension. In acute myocardial infarction the drug can be administered only under strict supervision. Do not use the drug in the first 3 months of pregnancy.

Product: pills to 0,002 grams (2 mg) in a package of 40 pieces.

Storage: List B. In the dark spot.