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Description medications: Apressin (Apressinum)
Apressin (Apressinum). 1 Gidrazinoftalazina hydrochloride.
Cinonimy: Anaspamine, Aprelazine, Apresolin, Appresoline, Aprezine, Deselazine, Dralzine, Eralazin, Hipoftalin, Homoton, Nydralazine, Hydralazini hydrochloridum, Hydrapress, Hypatol, Hyperazin, Hypophthalin, Idralazina, Ipolina, Lopress, Pressfall, Propectin, Radinol, Rolazine, Solesorin etc. Depressan (Derressan.) - 1-sulfate gidrazinoftalazina.
The white crystalline powder. Soluble in water at a ratio of 4: 4: 100, little - alcohol. C forms colored complexes with iron, and therefore avoid contact of the wetted product or its solutions with the iron objects.
Apressin belongs to the group of peripheral vasodilators. It reduces resistance resistant vessels (arterioles) and causes a decrease in blood pressure, strain on the myocardium, increases cardiac output.
Action apressina due to its antispasmodic effect on the myofibrils arterioles, and partly - decreasing central sympathetic tone. Antispasmodic effect, possibly due to the presence in the molecule apressina giprazinovoy group capable of delaying the inactivation of endogenous vasodilator factors, including oxide (oxide) of nitrogen (NOx).
Apply in various forms of hypertension (including for the relief of a crisis). The most indicated for patients with a hypokinetic type of blood circulation or resistive. Also effective in the treatment of eclampsia. The drug increases renal and cerebral blood flow. It is recommended for hypertension with renal insufficiency.
The peculiarities of action apressina include its ability to reflexively activates the sympathetic nervous system, enhance cardiac output and cause tachycardia, which can result in patients suffering from coronary artery disease, to enhance the effects of angina. Therefore, in recent years, combined with b apressin adrenoblokatorami (see. Inderal), reduces the circulatory hyperkinesis and tachycardia.
Apressin take orally after meals beginning with a dose of 0.01 - 0.025 g (10 - 25 mg) was 2 - 4 times a day, gradually increasing to 0.1 - 0.2 g (100 - 200 mg) per day (4 reception).
Higher doses for adults inside: single 0.1 g daily 0.3 g
The duration of treatment depends on the case: usually 1 course lasts 2 - 4 weeks. At the end of the course should interrupt treatment immediately, but gradually reducing the dose.
Typically, the hypotensive effect is maintained for a long time after treatment.
It is recommended to appoint apressin in combination with other antihypertensive drugs, which makes it possible to use smaller doses.
When combined with anaprilinom last administered in a daily dose of 80 240 mg; dihlotiazid yield 100 mg per day.
Basically apressin recommended short courses, in order to reduce high blood pressure. For maintenance therapy it is necessary to switch to other antihypertensive agents.
When using apressina possible headache, tachycardia, dizziness, pain in the heart, hot flashes, sweating, tearing, nausea, vomiting, erythematous rash, swelling of various localization, increased body temperature; It may also develop orthostatic collapse.
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