Description of the medicine: Apressin (Apressinum)
APRESSIN (Apressinum). 1-Hydrazinophthalazine hydrochloride.
Synonyms: Anaspamine, Aprelazine, Apresolin, Appresoline, Aprezine, Deselazine, Dralzine, Eralazin, Hipoftalin, Homoton, Hydralazine, Hydralazini hydrochloridum, Hydrapress, Hypatol, Hyperazin, Hypophthalin, Idralazina, Irolin, Radolina, Irolin Pollin, Idralazina, Irolina and others. Depressan (Derssan) - 1-hydrazinophthalazine sulfate.
White crystalline powder. It is soluble in water in a ratio of 4, 4: 100, little in alcohol. It forms colored complexes with iron, and therefore, contact of a moistened preparation or its solutions with iron objects should be avoided.
Apressin belongs to the group of peripheral vasodilators. It reduces the resistance of resistant vessels (arterioles) and causes a decrease in blood pressure, the load on the myocardium, increases cardiac output.
The effect of apressin is due to its antispasmodic effect on myofibrils of arterioles, and in part - a decrease in central sympathetic tone. The antispasmodic effect is possibly associated with the presence in the apressin molecule of a hyprazine group capable of delaying the inactivation of endogenous vasodilating factors, including nitric oxide (oxide) (NO).
Apply with different forms of arterial hypertension (including for relief of crisis). Most indicated for patients with hypokinetic or resistive type of blood circulation. It is also effective in the treatment of eclampsia. The drug enhances renal and cerebral blood flow. Recommended for hypertension with renal failure.
The ability of apressin to relate to its ability to reflexively activate the sympathetic nervous system, increase cardiac output and cause tachycardia, which can lead to an increase in angina pectoris in patients suffering from coronary insufficiency. Therefore, in recent years, apressin has been combined with b-blockers (see Anaprilin), which reduce circulatory hyperkinesis and tachycardia.
Apressin is taken orally after a meal, starting with a dose of 0.01-0.025 g (10-25 mg) 2-4 times a day, gradually increasing to 0.1-0.2 g (100-200 mg) per day (4 reception).
Higher doses for adults inside: single 0.1 g daily 0.3 g
The duration of treatment depends on the characteristics of the case: usually 1 course lasts 2 to 4 weeks. At the end of the course, treatment should not be interrupted immediately, but gradually, reducing the dose.
Typically, the hypotensive effect persists for a long time after a course of treatment.
It is recommended to prescribe apressin in combination with other antihypertensive drugs, which makes it possible to use lower doses.
When combined with anaprilin, the latter is prescribed in a daily dose of 80,240 mg; dichlothiazide is given at 100 mg per day.
In general, apressin is recommended to be used in short courses, to reduce high blood pressure. For maintenance therapy, it is necessary to switch to other antihypertensive drugs.
When using apressin, headache, tachycardia, dizziness, pain in the heart area, flushing of the head, sweating, lacrimation, nausea, vomiting, erythematous rashes, edema of various localization, increased body temperature are possible; Orthostatic collapse may also develop.