Description of the medicine: Minoxydil (Minoxydin)
MINOXYDIN. 2, 4-Diamino-6-piperidinopyrimidine-3-oxide:
Synonyms: Rigaine, Loniten, Lonolax, Lonoten, Prexidil, Regaine.
Has a peripheral vasodilator effect, expands resistant vessels (arterioles); Reduces the systemic blood pressure, reduces the load on the myocardium.
It is believed that the vasodilator and hypotensive effect of minoxidil is due to the fact that it is an agonist (opener) of potassium channels in the smooth muscle of the vessels (see Hypotensive drugs).
Applied mainly in severe forms of hypertension, resistant to other vasodilators. Usually prescribed in combination with b-adrenoblockers and diuretics.
Is taken internally. The initial dose of 0.005 g (5 mg) per day with a gradual increase (every 2 to 3 days) for 2, 5 - 5 mg a day before the stabilization of blood pressure (10-25 mg per day with a further gradual decrease in dose). The daily dose is given in 2 divided doses with an interval of 12 hours.
From the release: tablets of 0.005 g (5 mg).
During the use of minoxidil, it was found that during hair loss during hair loss, hair growth is enhanced. In this regard, the company producing minoxidil ("Upjohn"), was released a special drug for topical use - rygein (regeyn) containing 2% minoxidil (20 mg minoxidil in 1 ml 60% ethanol with the addition of propylene glycol and water). The preparation is applied to the affected areas of the head 1 ml 2 times a day (morning and evening), regardless of the area of the lesion. Treatment is carried out for a long time (up to 1 year or more). A significant part of patients, with a duration of disease of no more than 3 to 5 years, had a positive effect.
The study of the efficacy and tolerability of the drug continues.