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Description of the medicine: Minoxidil (Minoxydin)

MINOXIDIL (Minoxydin) *. 2, 4-Diamino-6-piperidinopyrimidin-3-oxide:

Synonyms: Rigayne, Loniten, Lonolax, Lonoten, Prexidil, Regaine.

It has a peripheral vasodilator effect, dilates resistant vessels (arterioles); reduces systemic blood pressure, reduces the load on the myocardium.

It is believed that the vasodilating and hypotensive effect of minoxidil is due to the fact that it is an agonist (opener) of potassium channels in the smooth muscles of blood vessels (see Antihypertensives).

It is mainly used for severe forms of arterial hypertension resistant to other vasodilators. Usually prescribed in combination with b-blockers and diuretics.

Take inside. The initial dose of 0.005 g (5 mg) per day with its gradual increase (every 2 to 3 days) by 2, 5 to 5 mg per day until the blood pressure level stabilizes (10 to 25 mg per day with a further gradual decrease in dose). The daily dose is given in 2 divided doses with an interval of 12 hours

Frome release: tablets of 0.005 g (5 mg).

During the use of minoxidil, it was found that while taking the drug with baldness, there is an increase in hair growth. In this regard, the company producing minoxidil (Upjon) released a special drug for topical use - rigain (regein) containing 2% minoxidil (20 mg minoxidil in 1 ml of 60% ethanol with the addition of propylene glycol and water). The drug is applied to the affected areas of the head 1 ml 2 times a day (morning and evening), regardless of the area of ​​the lesion. Treatment is carried out for a long time (up to 1 year or more). A significant part of patients with a disease duration of not more than 3 - 5 years had a positive effect.

The study of the effectiveness and tolerability of the drug is ongoing.