Description medications: Aminophyllinum

Eufillin (Euphyllinum).

Theophylline at 1, 2-ethylenediamine. Theophylline content of about 80% ethylene diamine - 20%.

Synonyms: Aminophylline, Aminocardol, Aminophyllinum, Ammophyllin, Diaphyllin , Genophyllin, Methaphyllin, Neophyllin, Novphyllin, Synthophyllin, Theophyllamin, Theophylline ethylendiamine and others.

White or white with a yellowish tinge crystalline powder with a faint odor of ammonia. Soluble in water. Aqueous solutions (pH 9, 9 0, 7) aseptically prepared.

Action eufillina caused primarily by the content of theophylline. Ethylenediamine increases antispasmodic activity and promotes the dissolution of the drug. The molecular mechanism of action of aminophylline basically similar to the mechanism of action of theophylline.

Aminophylline important features is its water solubility and possibility of parenteral (intravenous) administration.

Like theophylline, aminophylline relaxes the bronchial muscles, lowers the resistance of blood vessels, dilates coronary vessels, lowers blood pressure in the pulmonary artery increases renal blood flow, has a diuretic effect, mainly due to a decrease in tubular reabsorption; It causes an increase in water excretion with urine and zlektrolitov, especially sodium and chlorine ions.

The drug strongly inhibits platelet aggregation.

Apply aminophylline in asthma and bronhiolospazmah different etiology (mainly for kupirovapiya attacks); hypertension in the pulmonary circulation, as well as in cardiac asthma, especially when accompanied by seizures and respiratory failure bronhiolospazmom the type of Cheyne Stokes. It is also recommended for the relief of cerebral vascular crises atherosclerotic origin, and improve brain blood circulation, reducing the intracranial pressure and brain edema in ischemic stroke, as well as in chronic cerebrovascular insufficiency. Preparation improves renal blood flow and may be used with appropriate indications.

Assign eufillin inside, muscles, veins and microclyster. Under the skin eufillina solutions are not introduced, because they cause tissue irritation.

The method of administration depends on the characteristics of the case: acute attacks of asthma and strokes administered intravenously, in less severe cases - intramuscularly or inside.

Inside adults take 0.15g after eating 1 - 3 times a day. Children inside yield rate of 7 - 10 mg / kg per day in 4 divided doses. Duration of treatment - from several days to several months.

In adults vein injected slowly (within 4 to 6 min) 0.12 0.24 g (5 - 10 mL of 2, 4% solution) previously diluted in 10 - 20 ml of isotonic sodium chloride solution. When the heart rate, dizziness, nausea, injection speed slow down or moving to a drip, for which 10 - 20 ml of a 2, 4% solution (0.24 0.48 g) diluted in 100 - 150 ml of isotonic sodium chloride solution; administered at 30 - 50 drops per minute. At impossibility of introducing into the vein is injected intramuscularly to 1 ml of a 24% solution.