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Description of the medicine: Diprophyllinum (Diprophyllinum)

DIPROFILLIN (Diprophyllinum). 7- (2, 3-Dioxipropyl) -theophylline.

Synonyms: Aristophyllin, Astrophyllin, Coronal, Coronarin, Corphyllamin-Neutral, Didrofillina, Diprophyllin, Dyphylline, Glyfyllin, Glyphyllin, Isophyllin, Neutraphyllin, Solufyllin, Thefylan, Teofene, etc.

White crystalline powder of bitter taste. Slowly soluble in water (1:10). Solutions (pH 5, 5 - 6, 5) are sterilized at +100 ° C for 30 minutes.

By pharmacological properties, it is close to theophylline and euphyllin, has a bronchodilator and moderate coronary dilatant effect, slightly enhances diuresis; does not have a pronounced stimulating effect on the central nervous system; it somewhat improves cerebral circulation. Compared with theophylline, it is less toxic, and compared with eufillin, it has a less powerful effect, but is less toxic and does not irritate the tissues.

Indications are the same as for aminophylline.

Assign inside, intravenously, intramuscularly. 5 - 10 ml (adults) of 2, 5% solution are injected intravenously (slowly!), Intramuscularly 3 - 5 ml of 10% solution 1 - 2 times a day. Inside take 0.2 - 0.5 g 3-4 times a day.

Also used in the form of rectal suppositories (Suppositoria cum Diprophyllino), containing 0.5 g of diprofillin. Enter into the rectum 1 candle 1 to 2 times a day (morning and evening), after a preliminary cleansing enema or spontaneous bowel movements.

The course of treatment is usually 10 to 20 days. If necessary, repeat the course after a 3 - 5-day break.

Higher doses for adults inside: single 1 g daily 3 g; intramuscularly and intravenously: single 0.3 g daily 1, 5 g.

Contraindications are the same as for aminophylline. Suppositories should not be prescribed for proctosigmoiditis and rectal fissures.

With prolonged use of suppositories with diprofillin, a laxative effect and a burning sensation in the anus are possible, which usually does not require discontinuation of the drug.

Method of release: powder; tablets of 0.2 g; 10% solution in ampoules of 5 ml; candles containing 0.5 g of the drug.

Storage: List B. In a cool, dark place.

Rp.: Tab. Diprophyllini 0.2 N. 20

DS 1 tablet 3 to 4 times a day.

Rp .: Sol. Diprophyllini 10% 5 ml

DtdN 6 in ampull.

S. 3 ml intramuscularly 1 to 2 times a day

NOTE For intravenous injection, dilute (under aseptic conditions) 1 ampoule (5 ml) of a 10% solution in 15 ml of water for injection and administer (slowly!) 5-10 ml each

Rp .: Supp. cum diprophyllino 0.5

N. 10