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Medication Description: Diprofillin (Diprophyllinum)

DIPROFILLIN (Diprophyllinum). 7- (2, 3-dioxypropyl) -theophylline.

Synonyms: Aristophyllin, Astrophyllin, Coronal, Coronarin, Corphyllamin-Neutral, Didrofillina, Diprophyllin, Dyphylline, Glyfyllin, Glyphyllin, Isophyllin, Neutraphyllin, Solufyllin, Thefylan, Teofene et al.

White crystalline powder bitter taste. Slowly soluble in water (1:10). Solutions (pH 5, 5-6, 5) are sterilized at +100 ° C for 30 minutes.

On pharmacological properties it is close to theophylline and aminophylline, has a bronchodilator and moderate coronary dilatation, slightly increases diuresis; does not have a pronounced excitatory effect on the central nervous system, improves cerebral circulation somewhat. In comparison with theophylline, it is less toxic, and in comparison with aminophylline it has a less potent effect, but it is less toxic and does not irritate the tissue.

Indications are the same as for aminophylline.

Assign inside, intravenously, intramuscularly. Intravenously injected (slowly!) 5 - 10 ml (adults) of a 2, 5% solution, intramuscularly 3 - 5 ml of a 10% solution 1 - 2 times a day. Inside take 0.2 - 0.5 g 3 - 4 times a day.

Also used in the form of rectal suppositories (Suppositoria cum Diprophyllino), containing 0.5 g of diprofillin. Enter into the rectum 1 candle 1 to 2 times a day (morning and evening), after a preliminary cleansing enema or spontaneous emptying of the intestine.

The course of treatment is usually 10 - 20 days. If necessary, repeat the course after a 3 - 5-day break.

Higher doses for adults inside: single 1 g daily 3 g; intramuscularly and intravenously: single 0.3 g, daily 1, 5 g

Contraindications are the same as for aminophylline. Candles should not be prescribed for proctosigmoiditis and rectal fissures.

With prolonged use of candles with diprofillin, a laxative effect and a burning sensation in the anus are possible, which usually does not require discontinuation of the drug.

Method of issuance: powder; tablets of 0.2 g; 10% solution in 5 ml ampoules; candles containing 0.5 g of the drug.

Storage: List B. In a cool, dark place.

R p.: Tab. Diprophyllini 0,2 N. 20

DS 1 tablet 3-4 times a day.

R p. Sol. Diprophyllini 10% 5 ml

DtdN 6 in ampull.

S. 3 ml intramuscularly 1 - 2 times a day

Note. For intravenous injections, dilute (under aseptic conditions) 1 vial (5 ml) of a 10% solution in 15 ml of water for injection and inject (slowly!) 5 to 10 ml

R p .: Supp. cum Diprophyllino 0.5

N. 10