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Description of the medicine: Diprophylline (Diprophyllinum)

DIPROFILLIN (Diprophyllinum). 7- (2, 3-Dioxipropyl) -theophylline.

Synonyms: Aristophyllin, Astrophyllin, Coronal, Coronarin, Corphyllamin-Neutral, Didrofillina, Diprophyllin, Dyphylline, Glyfyllin, Glyphyllin, Isophyllin, Neutraphyllin, Solufyllin, Thefylan, Teofene, and others.

White fine crystalline powder of bitter taste. Slowly soluble in water (1:10). Solutions (pH 5, 5 - 6, 5) are sterilized at +100 ° C for 30 minutes.

According to its pharmacological properties, it is close to theophylline and euphyllin, it has a bronchodilating and moderate coronary expansive effect, increases diuresis somewhat; On the central nervous system has no pronounced excitatory effect, slightly improves cerebral circulation. Compared with theophylline, it is less toxic, and in comparison with euphyllin has a less potent effect, but is less toxic and does not irritate the tissue.

The indications are the same as for euphyllin.

Assign inside, intravenously, intramuscularly. Intravenously inject (slowly!) 5 - 10 ml (adult) 2, 5% solution, intramuscularly 3 - 5 ml 10% solution 1 - 2 times a day. Inside take 0.2 - 0.5 g 3 - 4 times a day.

They are also used in the form of rectal suppositories (Suppositoria cum Diprophyllino) containing 0.5 g of dipropylline. Enter into the rectum 1 candle 1 - 2 times a day (morning and evening), after a preliminary cleansing enema or spontaneous bowel movement.

The course of treatment is usually 10 to 20 days. If necessary, repeat the course after a 3 - 5-day break.

Higher doses for adults inside: single 1 g, daily 3 g; Intramuscularly and intravenously: single 0.3 g, daily 1, 5 g.

Contraindications are the same as for euphyllin. Candles should not be prescribed for proctosigmoid and rectal fissures.

With prolonged use of suppositories with diprofilin, a laxative effect and burning sensation in the anus can occur, which usually does not require the drug to be withdrawn.

Form release: powder; Tablets of 0.2 g; 10% solution in 5 ml ampoules; Candles containing 0.5 g of the drug.

Storage: List B. In a cool, sheltered from the world place.

RR .: Tab. Diprophyllini 0.2 N. 20

DS 1 tablet 3 to 4 times a day.

RR: Sol. Diprophyllini 10% 5 ml

DtdN 6 in ampull.

S. To 3 ml intramuscularly 1 - 2 times a day

NOTE For intravenous injections, dilute (in aseptic conditions) 1 ampoule (5 ml) of 10% solution in 15 ml of water for injection and inject (slowly!) 5 to 10 ml

RR .: Supp. Cum Diprophyllino 0.5

N. 10

DS