Description medications: ksantinola nicotinate (Xantinoli nicotinas)

Ksantinola nicotinate (Xantinoli nicotinas). 7- [2-Hydroxy-3- (N-methyl -oksietilamino b) -propyl] nicotinate -teofillina.

The white crystalline powder, readily soluble in water, a little - in alcohol.

Synonyms: komplamin, Ksavin, Sadamin, Teonikol, Angioamin, Complamex, Complamin, Contamex , Mehemin, Sadamin, Teonicol, Vedrin, Xantinol nicotinate, Xavin and others.

The product combines the properties of a group of substances theophylline and nicotinic acid (see.).

Increase peripheral vessels, improves peripheral collateral circulation, cerebral blood flow and reduces the effects of cerebral hypoxia, improves microcirculation in the vessels of the retina of the eye. Reduces the aggregation of platelets. Like theophylline enhances the contraction of the heart.

Apply ksantinola nicotinate in obliterating atherosclerosis of the lower extremities, intermittent claudication, Raynaud's disease, diabetic angiopathy, retinopathy, poorly healing venous ulcers of the lower extremities, as well as atherosclerotic cerebrovascular disorders, migraine, Meniere's syndrome. The drug increases cerebral blood flow and improves metabolic processes in the brain postoperative period after removal of a brain tumor, brain injury et al. (There is evidence that intravenous administration komplamin brain vessels extend only a short time and at the same time complicated blood flow in the cerebral vein. Therefore, the drug should not be used during intracranial stagnation, as well as in cases where the pulse oscillation is contraindicated strengthening brain.).

There are also data on the use ksantinola nicotinate in some dermatoses associated with trophic disorders of the vascular nature (scleroderma, atopic dermatitis, and others.).

Assign drug inside, intramuscularly or intravenously.

Inside are from 1 tablet (0.15 g) 3 times a day after meals; if necessary, the dose was increased to 2 - 3 tablets 3 times a day. Tablets are swallowed without chewing. As improvement, the dose was reduced to 2 tablets 1 - 3 times a day. The course of treatment is usually two months.

Circulatory disorders at acute tissue injected intramuscularly with 2 ml of a 15% solution (1 ampoule containing 0.3 g product) 1 - 3 times per day with gradual increase in the dose of 0.6 - 0.9 g of (4 - 6 mL of 15% solution) 2 - 3 times per day. The duration of treatment depends on the case (2 - 3 weeks).

In severe violations of peripheral and cerebral circulation injected (very slowly!) In 2 ml of a 15% solution of 1 - 2 times a day; then pass to an intramuscular injection (2 ml 1 - 3 times a day); at the same time designate the interior of 2 tablets 3 times a day.

In severe cases, the drug can also be administered intravenously. diluted to 10 mL of 15% solution (1 5 g) in 200 or 500 ml of 5% glucose solution or isotonic sodium chloride solution. Is administered for 1 - 4 hours to 4 times per day. Treatment duration of 5 - 10 days.