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Medication Description: Xantinol Nicotinate (Xantinoli nicotinas)

XANTHINOLA NICOTINAT (Xantinoli nicotinas). 7- [2-Oxy-3- (N-methyl-b -oxyethylamino) -propyl] -theophylline nicotinate.

White crystalline powder, easily soluble in water, low in alcohol.

Synonyms: Complamin, Xavin, Sadamin, Theonikol, Angioamin, Complamex, Complamin, Contamex, Mehemin, Sadamin, Teonicol, Vedrin, Xantinol nicotinate, Xavin, etc.

The drug combines the properties of substances of theophylline group and nicotinic acid (see).

It expands peripheral vessels, improves peripheral collateral circulation, cerebral circulation and reduces the effects of cerebral hypoxia, improves microcirculation in the retinal vessels of the eye. Reduces platelet aggregation. Like theophylline, it strengthens the contractions of the heart.

Apply xanthine nicotinate with obliterating atherosclerosis of the lower extremities, intermittent claudication, Raynaud's disease, diabetic angiopathy, retinopathy, poorly healing trophic ulcers of the lower extremities, as well as with atherosclerotic disorders of cerebral circulation, migraine, syndrome Syndrome, and atherosclerotic disorders of cerebral circulation, migraine, syndrome Syndrome, and for atherosclerotic disorders of cerebral circulation, migraine, syndrome, Gastrointestinal Syndrome, and atherosclerotic disorders of cerebral circulation, migraine, syndrome, Gynecology The drug enhances cerebral blood flow and improves the metabolic processes of the brain in the postoperative period after the removal of brain tumors, brain contusions, etc. (There is evidence that intravenous administration of complamine, brain vessels expand only briefly and at the same time, the outflow of blood into the brain veins is hampered. Therefore, the drug should not be used for intracranial congestion, as well as in cases where the increase in pulse oscillations of brain vessels is contraindicated.).

There is also evidence on the use of xanthine nicotinate for some dermatoses associated with trophic disorders of a vascular nature (scleroderma, neurodermatitis, etc.).

Assign the drug inside, intramuscularly or intravenously.

Inside take, starting with 1 tablet (0.15 g) 3 times a day after meals; if necessary, increase the dose to 2 to 3 tablets 3 times a day. Tablets are swallowed without chewing. As the state improves, the dose is reduced to 1 tablet 2 - 3 times a day. The course of treatment is usually 2 months.

In acute disorders of the blood supply to the tissues, 2 ml of a 15% solution is injected intramuscularly (1 ampoule contains 0.3 g of the drug) 1 to 3 times a day with a gradual increase in dose to 0.6 to 0.9 g (4 to 6 ml of 15% solution) 2 - 3 times a day. The duration of treatment depends on the characteristics of the case (up to 2 - 3 weeks).

In case of acute disorders of the peripheral and cerebral circulation, they are administered intravenously (very slowly!) In 2 ml of a 15% solution 1 to 2 times a day; then move to intramuscular injections (2 ml 1 - 3 times a day); at the same time administered orally 2 tablets 3 times a day.

In severe cases, the drug can also be administered intravenously. To do this, dilute 10 ml of 15% solution (1, 5 g) in 200 or 500 ml of 5% glucose solution or isotonic sodium chloride solution. Enter within 1-4 hours up to 4 times per day. The duration of treatment is 5 to 10 days.