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Description of the medicine: Xanthinol nicotinate (Xantinoli nicotinas)

XANTHINOL NICOTINATE (Xantinoli nicotinas). 7- [2-hydroxy-3- (N-methyl-b-hydroxyethylamino) propyl] theophylline nicotinate.

White crystalline powder, easily soluble in water, little in alcohol.

Synonyms: Complamin, Xavin, Sadamin, Theonicol, Angioamin, Complamex, Complamin, Contamex, Mehemin, Sadamin, Teonicol, Vedrin, Xantinol nicotinate, Xavin, etc.

The drug combines the properties of the substances of theophylline group and nicotinic acid (see).

Expands peripheral vessels, improves peripheral collateral circulation, cerebral circulation and reduces cerebral hypoxia, improves microcirculation in the vessels of the retina. Reduces platelet aggregation. Like theophylline, it enhances heart contractions.

Xantinol nicotinate is used for atherosclerosis obliterans of the lower extremities, intermittent claudication, Raynaud's disease, diabetic angiopathy, retinopathy, poorly healing trophic ulcers of the lower extremities, as well as atherosclerotic disorders of cerebral circulation, migraine, Meniere's syndrome. The drug enhances cerebral blood flow and improves brain metabolic processes in the postoperative period after removal of brain tumors, brain bruises, etc. (There is evidence that with intravenous administration of compliment, the blood vessels of the brain expand only for a short time and, at the same time, outflow of blood to the veins of the brain is difficult. Therefore, the drug should not be used for intracranial congestion, as well as in cases where the increase in pulse fluctuations in the blood vessels of the brain is contraindicated.).

There is also evidence of the use of xanthinol nicotinate in some dermatoses associated with trophic disorders of a vascular nature (scleroderma, neurodermatitis, etc.).

Prescribe the drug orally, intramuscularly or intravenously.

Inside, take, starting with 1 tablet (0.15 g) 3 times a day after meals; if necessary, increase the dose to 2 to 3 tablets 3 times a day. The tablets are swallowed without chewing. As the condition improves, the dose is reduced to 1 tablet 2 to 3 times a day. The course of treatment is usually 2 months.

In acute disorders of blood supply to the tissues, 2 ml of a 15% solution are administered intramuscularly (1 ampoule contains 0.3 g of the drug) 1-3 times a day with a gradual increase in dose to 0.6 - 0.9 g (4-6 ml 15% solution) 2 to 3 times a day. The duration of treatment depends on the characteristics of the case (up to 2 to 3 weeks).

In acute disorders of peripheral and cerebral circulation, 2 ml of a 15% solution are administered intravenously (very slowly!) 1-2 times a day; then they switch to intramuscular injections (2 ml 1-3 times a day); at the same time, 2 tablets are prescribed orally 3 times a day.

In severe cases, the drug can also be administered intravenously. To do this, dilute 10 ml of a 15% solution (1, 5 g) in 200 or 500 ml of a 5% glucose solution or isotonic sodium chloride solution. Enter for 1 to 4 hours up to 4 times a day. The duration of treatment is 5 to 10 days.