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Medication Description: Haloperidol (Haloperidolum)

HALOPERIDOL (Haloperidolum). 4- (para Chlorophenyl) -1 (3'- (para-fluorobenzoyl) -propyl] -piperidol-4, or 4- [4- (para-chlorophenyl) -4-hydroxypiperidino] -4'-fluorobutyrophenone.

Synonyms: Halofen, Aloperidin, Haldol, Halidol, Haloperidin, Haloperin, Halophen, Haloperidol, Halopidol, Serenace, Seranase, etc.

Haloperidol is one of the most active modern antipsychotics. It has a sedative effect, potentiates the action of sleeping pills, drugs and analgesics. Blocks central a -radrarenergic and especially strongly central dopaminergic receptors; central and peripheral anticholinergic has no effect. Relatively often causes extrapyramidal disorders. It has a strong antiemetic effect.

Haloperidol is an effective remedy for stopping various kinds of arousal, especially in manic states, acute delirium. Often effective in patients resistant to other antipsychotic drugs. Unlike chlorpromazine, it does not cause lethargy and apathy in patients, on the contrary, it has an activating effect.

Applied with schizophrenic psychosis, manic states, paranoid delusional states, with agitated depression, oligophrenic, involutional, epileptiform, alcoholic psychosis and other diseases accompanied by hallucinations, psychomotor agitation.

In the case of delirium tremens with visual hallucinations under the influence of haloperidol, motor sedation quickly occurs and hallucinations disappear.

Haloperidol can be used in combination with sleeping pills, analgesics and other neurotropic drugs in preparation for operations. There is evidence of the effectiveness of the drug for the relief of pain, agitation, nausea and vomiting in acute coronary insufficiency (more often with analgesics).

As an antiemetic, it can be used for vomiting of various origins.

In small doses, it is used in neurotic and reactive states.

Assign inside (before meals) or intramuscularly.

The initial daily dose in the absence of pronounced arousal is 0.0015 - 0.003 g (1, 5 - 3 mg) by mouth, and in patients resistant to neuroleptic drugs - 0.0045 g (4, 5 mg). The daily dose is divided into 3 doses and taken in tablets or drops half an hour after meals. Daily dose increased by 0.5 - 2 mg (in resistant cases, 2 - 4 mg) to obtain a therapeutic effect. Therapeutic daily dose is usually 10 - 15 mg per day, and in chronic forms of schizophrenia - 20 - 40 mg (up to 50 - 60 mg). Duration of treatment 2 -3 months. Reduce the dose slowly. Maintenance doses range from 0.5 to 5 mg per day.

Children under 5 years old give 1/4 from 6 to 15 years - 1/2 dose of adults.

For relief of psychomotor agitation prescribed intramuscularly in the first days for 2 to 5 mg (0.4 to 1 ml of 0.5% solution) 2 to 3 times a day. Upon reaching the effect, they proceed to the drug intake.

As an antiemetic haloperidol administered orally to adults for 0,0015 0,002 g (1, 5 - 2 mg); as soothing - 0.0005 g (0.5 mg).