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Description of the medicine: Haloperidol (Haloperidolum)

Haloperidol (Haloperidolum). 4- (para-chlorophenyl) - 1 [3'- (para-fluorobenzoyl) -propyl] -piperidinol-4, or 4- [4- (para-chlorophenyl) -4-hydroxypiperidino] -4'-fluorobutyrophenone.

Synonyms: Halofen, Aloperidin, Haldol, Halidol, Haloperidin, Haloperin, Halophen, Haloperidol, Halopidol, Serenace, Seranase, etc.

Haloperidol is one of the most active modern antipsychotics. It has a sedative effect, potentiates the effect of sleeping pills, drugs and analgesics. Blocks central a-noradrenergic and especially strongly central dopaminergic receptors; has no central and peripheral anticholinergic effect. Relatively often causes extrapyramidal disorders. It has a strong antiemetic effect.

Haloperidol is an effective tool for stopping all kinds of excitement, especially in manic states, acute delirium. Often effective in patients resistant to other antipsychotics. Unlike chlorpromazine, it does not cause lethargy and apathy in patients, on the contrary, it has an activating effect.

Used for schizophrenic psychoses, manic states, paranoid delusional states, agitated depression, oligophrenic, involutional, epileptiform, alcoholic psychoses and other diseases accompanied by hallucinations, psychomotor agitation.

In the case of alcohol delirium with visual hallucinations under the influence of haloperidol, motor sedation quickly sets in and hallucinations disappear.

Haloperidol can be used in combination with sleeping pills, analgesics and other neurotropic drugs in preparation for surgery. There is evidence of the effectiveness of the drug for the relief of pain, agitation, nausea and vomiting in acute coronary insufficiency (often together with analgesics).

As an antiemetic, it can be used for vomiting of various origins.

In small doses it is used for neurotic and reactive conditions.

Assign inside (before meals) or intramuscularly.

The initial daily dose in the absence of marked excitement is 0.0015-0.003 g (1.5-3 mg) by mouth, and in patients resistant to antipsychotic drugs, 0.0045 g (4.5 mg). The daily dose is divided into 3 doses and taken in tablets or drops half an hour after a meal. Daily increase the dose by 0.5 - 2 mg (in resistant cases by 2 - 4 mg) until a therapeutic effect is obtained. The therapeutic daily dose is usually 10-15 mg per day, and in chronic forms of schizophrenia, 20-40 mg (up to 50-60 mg). The duration of the course of treatment is 2 -3 months. Reduce the dose slowly. Maintenance doses range from 0.5 to 5 mg per day.

Children under the age of 5 are given 1/4 of 6 to 15 years - 1/2 doses of adults.

To stop psychomotor agitation, intramuscularly is prescribed in the first days, 2–5 mg (0.4–1 ml of a 0.5% solution) 2–3 times a day. Upon reaching the effect, they switch to taking the drug inside.

As an anti-emetic haloperidol, it is prescribed orally to adults at 0.0015 0.002 g (1.5 mg - 2 mg); as a sedative, 0.0005 g (0.5 mg) each.