Description medications: fendiline (Fendiline)
N- (2-Benzhydryl-ethyl-N-1-phenyl-ethyl) -amine hydrochloride.
Synonyms: Senzit, Phenaxazan, Phendilin, Phenoxan, Sensit .
White or slightly pink crystalline powder. It is soluble in water. It is soluble in alcohol.
On chemical structure similar to the directly previously released drug diffracted (prenylamine, korontin, falikor).
Both drugs are derived fenilalkilamina and are similar in structure to the fenaminu.
Diffracted (prenylamine) - one of the first drugs that have discovered the ability to block the passage of calcium into the cells' ~. It was synthesized by "weighting" fenilalkilamina molecule substance, blocking adrenergic receptors and rendering antiadrenergicheskim action. It was found that prenylamine (diffracted) unlike amphetamine Adrenomimeticalkie peripheral has no activity no stimulating effect on the central nervous system and, suppressing the transmission of the sympathetic pulses enhances the coronary vessels, improvement of blood circulation and metabolism in the myocardium. The drug found useful as antianginal agents. Then it was revealed its effect on the flow of C + and he came to be regarded as an antagonist of calcium ions.
In recent years, due to the lack of selectivity of action and a relatively weak diffracted antianginal activity was excluded from the range of medicines.
However, continue to use the proposed further drug fendiline (senzit) close to prepilaminu.
However fendiline (senzit) has a moderate anti-anginal effects in light and mild coronary insufficiency and has a moderate anti-arrhythmic activity. In general, the drug is less effective than other preparations of this group.
Assign inside of 1 - 2 tablets (50 mg) three times a day (for most patients Z00 mg per day).
Possible side effects: irritation of the mucous membrane of the stomach, pain, nausea, etc., headache, anxiety, allergic reactions..
Contraindications: pregnancy, the acute phase of myocardial infarction. Caution is required in patients with lesions of the liver. It should not be prescribed the drug at the same time b adrenoblokatorami.
Product: tablets, coated tablets (dragees), 0.05 g (50 mg) in a package of 50 pieces.
Storage: List B.