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Description of the medicine: Droperidol (Droperidolum)

DROPERIDOL (Droperidolum). 1- {1 - [3-para-Fluorobenzoyl) propyl] -1, 2, 3, 6-tetrahydro-4-pyridyl} 2-benzimidazolinone.

Synonyms: Dehydrobenzperidol, Dridol, Droleptan, Droperidol, Inapsin, Sintodril, etc.

Light cream crystalline powder. When stored in air and light yellow.

It is practically insoluble in water, slightly soluble in alcohol.

Antipsychotic from the group of butyrophenones. It has a quick, strong, but short-lived effect. When injected into a vein, the effect manifests itself after 2 - 5 minutes, reaches a maximum after 20 - 30 minutes. The action, depending on the dose, lasts up to 2 to 3 hours.

The drug potentiates the effect of analgesic and hypnotics. It has anti-shock and antiemetic properties. It has a -adrenolytic effect; blocks central dopamine receptors; does not have anticholinergic activity. Lowers blood pressure, has an antiarrhythmic effect. It has a strong cataleptogenic activity.

In psychiatric practice, droperidol is used for psychomotor agitation, hallucinations. It is mainly applied in anesthetic practice for neuroleptanalgesia usually in combination with fentanyl (see) or other analgesics.

The combined use of droperidol and fentanyl causes a quick antipsychotic and analgesic effect, drowsiness, muscle relaxation, prevents shock, and has an antiemetic effect. Patients easily come out of a state of antipsychotic analgesia.

Droperidol is used for sedation, during the operation and in the postoperative period. Used for endotracheal anesthesia, as well as for operations using local anesthesia.

Droperidol is administered under the skin, intramuscularly and intravenously.

With premedication and neuroleptanalgesia, droperidol is usually administered intramuscularly 30 to 45 minutes before surgery at a dose of 2.5-5 mg (1-2 ml of a 0.25% solution) along with 0.05-0.1 mg (1-2 ml of 0.005 % solution) fentanyl or 20 mg (1 ml 2% solution) of promedol. At the same time, 0.5 mg (0.5 ml of a 0.1% solution) of atropine or metacin is administered.

In endotracheal anesthesia, droperidol is first administered at the rate of 2.5 mg per 5 kg of body weight together with fentanyl at the rate of 0.05 mg per 5 kg of body weight (which corresponds to 1 ml of the combined preparation of thalamonal per 5 kg of body weight). Then, non-inhalation anesthetics, sodium oxybutyrate or tranquilizers (diazepam, sibazon) are used for anesthesia. Anesthesia is supported by nitrous oxide with oxygen in a ratio of 1: 1 or 3: 1. During the operation, every 15 to 30 minutes or when signs of weakening appear, additional fentanyl of 0.05 - 0.1 mg (1 - 2 ml) is administered. In case of cardiac arrhythmias, droperidol (2, 5 - 5 mg) is additionally administered.

Muscle relaxants are used to relax muscles.

During the injection of droperidol and fentanyl, the patient breathes a mixture of oxygen with nitrous oxide (1: 1).

With local anesthesia, droperidol is administered intravenously (slowly) or intramuscularly at a rate of 0.1 mg / kg.