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Medication Description: Droperidol (Droperidolum)

DROPERIDOL (Droperidolum). 1- {1 - [3-para-Fluoro-benzoyl) propyl] -1, 2, 3, 6-tetrahydro-4-pyridyl} 2-benzimidazolinone.

Synonyms: Dehydrobenzperidol, Dridol, Droleptan, Droperidol, Inapsin, Sintodril, etc.

Light cream crystalline powder. When stored in the air and in the light yellow.

Practically insoluble in water, slightly soluble in alcohol.

Neuroleptic agent from the group of butyrophenones. It has a quick, strong, but short-lasting effect. The effect when introduced into a vein manifests itself in 2–5 minutes, reaches a maximum in 20–30 minutes. The effect depending on the dose lasts up to 2 - 3 hours.

The drug potentiates the action of analgesic and hypnotic drugs. Possesses antishock and antiemetic properties. It has a -adrenolytic effect; blocks central dopamine receptors; does not possess anticholinergic activity. Lowers blood pressure, has an antiarrhythmic effect. It has strong cataleptogenic activity.

In psychiatric practice, droperidol is used for psychomotor agitation, hallucinations. It is mainly used in anesthesia practice for neuroleptic algesia, usually in combination with fentanyl (see) or other analgesics.

The combined use of droperidol and fentanyl causes a fast neuroleptic and analgesic effect, drowsiness, muscle relaxation, prevents shock, has an antiemetic effect. Patients easily get out of neuroleptic analgesia.

Droperidol is used for sedation, during surgery and in the postoperative period. Used with endotracheal anesthesia, as well as operations with the use of local anesthesia.

Droperidol is injected under the skin, intramuscularly and intravenously.

During sedation and neuroleptanalgesia, droperidol is usually administered intramuscularly 30–45 minutes before surgery at a dose of 2, 5–5 mg (1–2 ml of a 0.25% solution) together with 0.05–0.1 mg (1–2 ml of 0.005 % solution) fentanyl or 20 mg (1 ml 2% solution) of Promedol. 0.5 mg (0.5 ml of a 0.1% solution) of atropine or metacin is administered at the same time.

In endotracheal anesthesia, droperidol is first administered at a rate of 2.5 mg per 5 kg of body weight, together with fentanyl at a rate of 0.05 mg per 5 kg of body weight (which corresponds to 1 ml of the combined drug thalamonal per 5 kg of body weight). Then, inhalation anesthetics, sodium oxybutyrate or tranquilizers (diazepam, sibazone) are used for administration to anesthesia. Anesthesia is supported by nitrous oxide with oxygen in a 1: 1 or 3: 1 ratio. During the operation, every 15 to 30 minutes or when signs of weakness appear, an additional 0.05-0.1 mg fentanyl (1-2 ml) is administered. In case of cardiac arrhythmias, additionally droperidol (2, 5-5 mg) is administered.

Muscle relaxants are used to relax the muscles.

During the injection of droperidol and fentanyl, the patient breathes a mixture of oxygen and nitrous oxide (1: 1).

During local anesthesia, droperidol is administered intravenously (slowly) or intramuscularly at a rate of 0.1 mg / kg.