Medication Description: Parmidinum
Bis-N-methylcarbamine ester of 2, 6-bis-oxymethylpyridine, or 2, 6-pyridinyl-bis- (methyl-N-methylcarbamate).
Synonyms: Angina, Pyridinolcarbamate, Prodektin, Acesterol, Andil, Anginin, Angiovital, Angioxine, Angioxyl, Aterofal, Aterokin, ats, Atover, Cicloven, Colesterinex, Duaxol, Duvaline, Eluen, Exibral, Garparol, ats, ats, apr, ays, aystinx, Duaxol, Duaxol, Duvalol, Eluen, Exibral, Garparol, ats, apr, aystin, atover, Cicloven Vasagin, Vasapril, Vasocil, Vasoverin, Veranterol, etc.
White or almost white crystalline powder. Few soluble in water, it is difficult - in alcohol.
Parmidin has angioprotective activity, reduces vascular permeability, helps to restore impaired microcirculation in pathological processes. This is largely due to the effect on the kinin-kallikrein system, especially with a decrease in the activity of bradykinin. It also reduces platelet aggregation, stimulates fibrinogenesis.
Parmidine (angina) was originally proposed as an anti-sclerotic agent. As a bradykinin antagonist, it reduces the contraction of the endothelial cells of arteries, as well as the gaps between them and thus prevents the atherogenic lipoproteins from penetrating into the inner lining of the vessels. Possessing anti-inflammatory activity, Parmidin also reduces swelling of endothelial cells, preventing lipid infiltration of the inner lining of blood vessels, and contributes to the reverse development of infiltrative changes in atherosclerosis. He also has moderate hypocholesterolemic activity.
As an independent anti-sclerotic, parmidine is currently not used, but it is widely used as a means of complex therapy in the treatment of atherosclerosis of vessels of the brain, heart, extremities, in atherosclerotic and diabetic angiopathy, retinal thrombosis, obliterating endarteritis, and trophic ulcers of the extremities. The best effect was observed in peripheral vascular lesions, especially those of the lower extremities, in diabetic angiopathies, mainly diabetic retinopathy. There is evidence of the positive effect of the drug on the state of the stomach and pancreas in diabetes mellitus, as well as the feasibility of using pamidin (prodectin) in the complex treatment of patients with pulmonary tuberculosis. The drug accelerates the disappearance of symptoms of intoxication and resorption of infiltrates in the lungs. The tolerance of anti-tuberculosis chemotherapeutic drugs is improved.
Parmidin is advisable to combine with vitamins, enzymes, coenzymes, and if necessary with antidiabetic drugs (diabetic angiopathies). A marked tendency to normalization of lipid metabolism in chronic ischemic heart disease when taking Parmidine (Prodektin) in combination with lipoic acid.
Assign parmidine inside, starting with 0.25 g (1 tablet) 3 - 4 times a day. Then, with good portability, increase the dose to 0.75 g (3 tablets) 3 - 4 times a day. Typically, the daily dose is 1 to 2 g. The course of treatment is from 2 to 6 months or more.