Description of the medicine: Oxodolinum (Oxodolinum)
OXODOLIN (Oxodolinum). 1-oxo-3- (3'-sulfamoyl-4'-chlorophenyl) -3-hydroxyisoindoline.
Synonyms: Gigroton, Urandil, Chlorphtalidolone, Chlortalidone, Edemdal, Famolin, Hidronal, Higroton, Hygroton, Igroton, Isoren, Natriuran, Oradil, Phthalamidine, Renon, Saluretin, Urandil, Urofinil, Zambesil.
Fine crystalline powder, white or white with a slight yellowish tint. It is practically insoluble in water, slightly soluble in alcohol.
Oxodoline, like dichlothiazide, contains a sulfonamide group in the molecule. Like dichlothiazide, the drug blocks sodium reabsorption in the proximal part of the distal tubules, and partially affects the proximal tubules. A feature of the drug's action is the relative duration of the diuretic effect, which is associated with its slow elimination by the kidneys. The diuretic effect begins 2 to 4 hours after ingestion and usually lasts more than a day (sometimes 3 days). The drug is effective in some cases with refractoriness to dichlothiazide (hypothiazide).
Indications for use are the same as for dichlothiazide; prescribe the drug as not only a diuretic, but also an antihypertensive agent.
The drug is well absorbed when taken orally. It is excreted in urine (about 25%) and feces (about 75%).
Applied inside in the form of tablets (usually in the morning before breakfast). Doses are selected individually, depending on the severity of the disease and the effect.
When taken as a diuretic, a single dose may vary from 0.025 g (25 mg) to 0.1 g (100 mg). If necessary, to quickly reduce edema, increase a single dose to 0.2 g (200 mg), or use a combination with a diuretic that has a quick effect, for example with furosemide (in the morning - 0.04 - 0.08 g of furasemide, and after 6 - 8 hours - 0.05 - 0.1 g of oxodoline).
When the desired effect is achieved, they switch to intermittent use of the drug at 0.05 - 0.1 g after 2 to 3 days. Usually the course of treatment is 2 to 4 weeks. With arterial hypertension, intermittent (after 1 to 3 days) treatment with oxodoline can last for many months.
In case of hypertension and symptomatic hypertension, oxodoline is prescribed at 0.025 - 0.1 g 1 time per day (in the morning), more often it is used together with reserpine (0.05 g of oxodoline and 0.0025 g of reserpine), β-blockers, apressin.
The duration of treatment depends on the effect obtained and the tolerance of the drug.
Possible side effects, precautions and contraindications are the same as for dichlothiazide. Oxodoline has a slightly lower potassium-uretic effect than dichlothiazide, however, and when it is used, it is necessary to correct the potassium metabolism.
Release form: tablets of 0.05 g (50 mg) in a package of 50 pieces.
Storage: List B. In a dry, cool, dark place.
Oxadolin is a component of Neocristepine tablets (see Reserpine.).