Description of the medicine: Oxodolinum (Oxodolinum)
OXODOLINUM. 1-Oxo-3- (3'-sulfamoyl-4'-chlorophenyl) -3-hydroxyisoindoline.
Synonyms: Hygroton, Urandil, Chlorphtalidolone, Chlortalidone, Edemdal, Famolin, Hidronal, Higroton, Hygroton, Igroton, Isoren, Natriuran, Oradil, Phthalamidine, Renon, Saluretin, Urandil, Urofinil, Zambesil.
White or white with a weak yellowish tinge fine crystalline powder. Almost nerastvorim in water, little soluble in alcohol.
Oxodoline, as well as dichlorothiazide, contains a sulfonamide group in the molecule. Like dichlorothiazide, the drug blocks sodium reabsorption in the proximal part of the distal tubules, and partially affects the proximal tubules. A special feature of the drug is the relative duration of the diuretic effect, which is associated with its slow excretion by the kidneys. The diuretic effect begins 2 to 4 hours after ingestion and lasts usually more than a day (sometimes 3 days). The drug is effective in a number of cases with refractory to dichlorothiazide (hypothiazide).
Indications for use are the same as for dichlorothiazide; Prescribe the drug as not only a diuretic, but also an antihypertensive agent.
The drug is well absorbed when taken orally. It is excreted in urine (about 25%) and feces (about 75%).
Apply inward in the form of tablets (usually in the morning before breakfast). Doses are selected individually, depending on the severity of the disease and the effect.
When taken as a diuretic, a single dose can vary from 0.025 g (25 mg) to 0.1 g (100 mg). If necessary, rapidly reduce the edema increase a single dose to 0.2 g (200 mg), or use a combination with a diuretic that has a fast effect, for example with furosemide (in the morning - 0,04-0,08 g of furasemide, and in 6-8 hours 0.05-0.1 g of oxodoline).
When the desired effect is achieved, they switch to intermittent use of the drug at 0.05-0.1 g after 2 - 3 days. Usually the course of treatment is 2 - 4 weeks. With arterial hypertension, intermittent (1 to 3 days) treatment with oxodolin can last many months.
In hypertensive disease and symptomatic hypertension, oxodolin is prescribed by 0,025 - 0,1 g once a day (in the morning), it is often used together with reserpine (0.05 g of oxodoline and 0.0025 g of reserpine), b-adrenoblockers, and apressin.
The duration of treatment depends on the effect obtained and the tolerability of the drug.
Possible side effects, precautions and contraindications are the same as for dichlorothiazide. Oxodoline has a slightly lower potassium -uretic effect than dichlorothiazide, however, when it is used, it is necessary to correct potassium metabolism.
Form release: tablets of 0.05 g (50 mg) in a package of 50 pieces.
Storage: List B. In a dry, cool, sheltered from the world.
Oxadoline is an integral part of the tablets "Neocristepin" (see Reserpine.).