Medication Description: Oxodolin (Oxodolinum)
OXODOLINE (Oxodolinum). 1-Oxo-3- (3'-sulfamoyl-4'-chlorophenyl) -3-hydroxy-isoindoline.
Synonyms: Hygroton, Urandil, Chlorphtalidolone, Chlortalidone, Edemdal, Famolin, Hidronal, Higroton, Hygroton, Igroton, Isoren, Natriuran, Oradil, Phthalamidine, Renon, Saluretin, Urandil, Urofinil, Zambesil.
White or white with a faint yellowish crystalline powder. Practically insoluble in water, slightly soluble in alcohol.
Oxodolin, as well as dichlothiazide, contains a sulfonamide group in the molecule. Like dichlothiazide, the drug blocks sodium reabsorption in the proximal part of the distal tubules, and partially acts on the proximal tubules. A feature of the drug is the relative duration of the diuretic effect, which is associated with its slow elimination by the kidneys. The diuretic effect begins 2–4 hours after administration and usually lasts more than a day (sometimes 3 days). The drug is effective in some cases with refractoriness to dichlothiazide (hypothiazide).
Indications for use are the same as for dichlothiazide; prescribe the drug as not only diuretic, but also antihypertensive drugs.
The drug is well absorbed when taken orally. Excreted in the urine (about 25%) and feces (about 75%).
Apply inside in the form of tablets (usually in the morning before breakfast). Doses are selected individually, depending on the severity of the disease and the effect.
When taken as a diuretic, a single dose can vary from 0.025 g (25 mg) to 0.1 g (100 mg). If necessary, quickly reduce edema, increase the single dose to 0.2 g (200 mg), or use a combination with a diuretic that has a rapid effect, for example with furosemide (in the morning - 0.04 - 0.08 g of furasemide, and after 6 - 8 h - 0.05 - 0.1 g oxodoline).
When the desired effect is achieved, they switch to discontinuous use of the drug at 0.05-0.1 g after 2-3 days. Usually a course of treatment is 2 to 4 weeks. In hypertension, intermittent (after 1 - 3 days) treatment with oxodoline can last for many months.
In hypertension and symptomatic hypertension, oxodoline is prescribed at 0.025 - 0.1 g 1 time per day (in the morning), more often used together with reserpine (0.05 g oxodoline and 0.0025 g reserpine), b-adrenoblockers, apressin.
The duration of treatment depends on the effect obtained and the tolerability of the drug.
Possible side effects, precautions and contraindications are the same as for dichlothiazide. Oxodolin has a slightly smaller potassium uretic effect than dichlothiazide, however, and in its use it is necessary to correct the exchange of potassium.
Product form: tablets of 0.05 g (50 mg) in a package of 50 pieces.
Storage: List B. In a dry, cool, dark place.
Oxadolin is a component of the tablets "Neocristepin" (see. Reserpine.).