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Description of the medicine: Buphenoxum

BUFENOX (Buphenoxum). 3-Butylamino-4-phenoxy-5-sulfamoylbenzoic acid.

Synonyms: Bufenox, Bumetanid, Burinax, Burinex, Fluxil, Jurinex, Primex, Segurex and others.

White amorphous or fine-needle powder,

Almost nerastvorim in water, it is difficult soluble in alcohol.

By structure and action is close to furosemide. Has a rapidly onset and short diuretic effect with natriuretic and potassium-uretic effect.

The drug is well absorbed from the stomach. The increase in urinary excretion begins within the first hour after ingestion and lasts 4 to 6 hours. Indications for use are basically the same as for furosemide. Effective in smaller doses.

Bufenox prescribed inside (usually in the morning before breakfast). Doses are selected individually depending on the severity of the disease and the effect.

A single dose of 0.001 g. In the absence of the desired effect, it is increased to 0.002 g.

The highest daily dose of 0.006 g (6 mg). Tablets should be taken for 3 to 5 consecutive days, then switched to intermittent reception at 0,001 - 0,002 g once every 2 to 3 days. The duration of the course and the total duration of treatment depend on the severity and nature of the disease, the effect obtained and the tolerability.

In severe edematous syndrome appoint usually consecutively for 3 - 5 days, then take 1 - 2 mg (0.001 - 0.002 g) 1 time in 2 -3 days.

Intravenous and intramuscularly, bufenox is used only in hospital settings if necessary to obtain a rapid effect (with swelling of the lungs, brain, etc.), as well as difficulty swallowing and impaired absorption.

The optimal single dose for parenteral administration is 0.5-1 mg (2-4 ml 0.025% solution).

In a vein enter slowly (within 2 - 3 minutes); The contents of the ampoule are diluted with 20 ml of isotonic sodium chloride solution or 5% glucose solution.

If necessary, repeat the injection after 4-8 hours.

The highest daily dose for parenteral administration is 0.005 g (5 mg).

Possible side effects and contraindications are the same as for furosemide and dichlorothiazide. During treatment it is recommended to eat foods rich in potassium salts.

Forms of release: tablets of 0,001 g (1 mg) in a package of 50 pieces; 0,025% solution (clear colorless liquid) in ampoules of 2 ml in a package of 10 ampoules.

Storage: List B. In the dark place.