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Description of the medicine: Buphenox (Buphenoxum)

BUFENOX (Buphenoxum). 3-Butylamino-4-phenoxy-5-sulfamoylbenzoic acid.

Synonyms: Bufenox, Bumetanid, Burinax, Burinex, Fluxil, Jurinex, Primex, Segurex, etc.

White amorphous or fine needle powder,

It is practically insoluble in water, it is hardly soluble in alcohol.

In structure and action, it is close to furosemide. It has a fast onset and short diuretic effect with a natriuretic and potassiumuretic effect.

The drug is well absorbed from the stomach. Strengthening urine excretion begins within the first hour after ingestion and lasts 4-6 hours. Indications for use are basically the same as for furosemide. Effective in smaller doses.

Bufenox is prescribed orally (usually in the morning before breakfast). Doses are selected individually depending on the severity of the disease and the effect.

A single dose of 0.001 g. In the absence of the desired effect, it is increased to 0.002 g.

The highest daily dose of 0.006 g (6 mg). Tablets are best taken for 3 to 5 days in a row, then they switch to intermittent intake of 0.001 to 0.002 g once every 2 to 3 days. The duration of the course and the total duration of treatment depend on the severity and nature of the disease, the effect obtained and tolerance.

With severe edematous syndrome, it is usually prescribed in a row for 3 to 5 days, then 1 to 2 mg (0.001 to 0.002 g) is taken once every 2 to 3 days.

Bphenox is used intravenously and intramuscularly only in a hospital if necessary to obtain a quick effect (with pulmonary edema, brain, etc.), as well as with difficulty swallowing and malabsorption.

The optimal single dose for parenteral administration is 0.5-1 mg (2-4 ml of a 0.025% solution).

Enter into a vein slowly (within 2 - 3 min); the contents of the ampoule are diluted with 20 ml of isotonic sodium chloride solution or 5% glucose solution.

If necessary, repeat the injection after 4 to 8 hours.

The highest daily dose for parenteral administration of 0.005 g (5 mg).

Possible side effects and contraindications are the same as for furosemide and dichlothiazide. During treatment, it is recommended to eat foods rich in potassium salts.

Method of release: tablets of 0.001 g (1 mg) in a package of 50 pieces; 0.025% solution (clear, colorless liquid) in 2 ml ampoules in a package of 10 ampoules.

Storage: List B. In the dark place.