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Medication Description: Bufenox (Buphenoxum)

BUPHENOX (Buphenoxum). 3-Butylamino-4-phenoxy-5-sulfamoylbenzoic acid.

Synonyms: Bufenox, Bumetanid, Burinax, Burinex, Fluxil, Jurinex, Primex, Segurex, etc.

White amorphous or fine needle powder,

Practically insoluble in water, difficult to dissolve in alcohol.

The structure and action close to furosemide. It has a fast-on and short diuretic effect with a natriuretic and potassium-uretic effect.

The drug is well absorbed from the stomach. Increased excretion of urine begins within the first hour after ingestion and lasts 4 to 6 hours. Indications for use are basically the same as for furosemide. Effective in smaller doses.

Bufenox is prescribed by mouth (usually in the morning before breakfast). Doses are selected individually depending on the severity of the disease and the effect.

A single dose of 0.001 g. In the absence of the desired effect, it is increased to 0.002 g.

The highest daily dose is 0.006 g (6 mg). Tablets are best taken within 3 - 5 days in a row, then move to a discontinuous intake of 0.001 - 0.002 g 1 time in 2 - 3 days. The duration of the course and the total duration of treatment depend on the severity and nature of the disease, the effect obtained and the tolerance.

In case of severe edema syndrome, it is usually prescribed for 3–5 days in a row, then take 1–2 mg (0.001–0.002 g) once every 2-3 days.

Intravenously and intramuscularly, bufenox is used only in a hospital if necessary to get a quick effect (in case of pulmonary edema, brain, etc.), as well as in case of difficulty swallowing and impaired absorption.

The optimal single dose for parenteral administration is 0.5-1 mg (2-4 ml of a 0.025% solution).

Enter into a vein slowly (within 2 - 3 min); the contents of the ampoule is diluted with 20 ml of isotonic solution of sodium chloride or 5% glucose solution.

If necessary, repeat the injection after 4 to 8 hours.

The highest daily dose for parenteral administration is 0.005 g (5 mg).

Possible side effects and contraindications are the same as for furosemide and dichlothiazide. During treatment, it is recommended to eat foods rich in potassium salts.

Method of production: tablets of 0.001 g (1 mg) in a package of 50 pieces; 0.025% solution (clear, colorless liquid) in ampoules of 2 ml per pack of 10 ampoules.

Storage: List B. In the dark spot.