Description medications: Triamterene (Triamterenum)
Triamterene (Triamterenum). 2, 4, 7-triamino-6-fenilpteridin7
Synonyms: Pterofen, Amteren, Diutac, Diuteren, Dyren , Dyrenium, Dytac, Fluxinar, Jatropur, Neuuron, Noridyl, Pterofen, Reviten, Taturil, Teridin, Triamterene, Triarene, Trispan, Triteren, Triurene, Urocaudal and others.
Triamterene reduces the permeability of cell membranes of distal tubules to sodium ions and increases their excretion in the urine without increasing the allocation of potassium ions. The secretion of potassium ions in the distal tubule decreases. The drug can reduce hypokalemia caused benzotiadiazina derivatives, and enhance the diuretic effect of the latter.
The drug is rapidly absorbed; diuretic effect observed after oral administration in 15 - 20 minutes, the maximal effect - 2 - 3 hours after administration and maintained for 12 hours.
Apply with swelling caused by circulatory failure, liver cirrhosis, nephrotic syndrome. In connection with the potassium-sparing effect is particularly indicated for combination use in conjunction with thiazide diuretics, and in patients with symptoms of intolerance digitalis glycosides, which is based on hypokalemia.
Assign inside alone and in combination with other diuretics. With self-use - 0.05 - 0.1 0.2 g per day (1 - 2 doses - after breakfast and dinner), in combination therapy - lower doses (eg, 0.025 g and 0.0125 g triamterena dihlotiazida) . Increase the dose gradually (to avoid too rapid and profuse diuresis).
Usually taking the drug on a daily basis.
When receiving triamterene may, in some cases, nausea, vomiting, headache, decreased blood pressure.
Alkalosis, acidosis, a delay of uric acid were observed, but it is possible hyperkalemia. Prolonged use may increase the content of urea in the blood. In these cases it is recommended to take the drug every day, and a day later and in smaller doses, alternating with taking diuretics group benzotiadiazina. In some patients, the application of triamterena develop hyperglycemia and hyperuricemia.
Product: 0.05 g capsules (50 mg) formulation.
Storage: List B.
Entitled "Triampur kompozitum" (Triampur sompositum) in Germany are released tablets containing 25 mg of triamterene and 12, 5 mg digidrohlortiazida (dihlotiazida). Assign with cardiac, renal edema, ascites, cirrhosis of the liver, and so on. N.
Is usually on an outpatient basis at 1 tablet 2 times a day (morning and afternoon after a meal) in the hospital - 2 tablets 2 times a day.
Product: tablets in a package of 50 pieces.
Similar domestic product is produced under the name "Triamtezid" (Triamtezidum).