Description of the medicine: Triamterenum (Triamterenum)
TRIAMTEREN (Triamterenum). 2, 4, 7-Triamino-6-phenylpteridine 7
Synonyms: Pterofen, Amteren, Diutac, Diuteren, Dyren, Dyrenium, Dytac, Fluxinar, Jatropur, Neuuron, Noridyl, Pterofen, Reviten, Taturil, Teridin, Triamterene, Triarene, Trispan, Triteren, Triudalne, Ure.
Triamteren reduces the permeability of the cell membranes of the distal tubules for sodium ions and enhances their excretion in the urine without increasing the excretion of potassium ions. The secretion of potassium ions in the distal tubules decreases. The drug is able to reduce hypokalemia caused by benzothiadiazine derivatives and enhance the diuretic effect of the latter.
The drug is rapidly absorbed; diuretic effect after oral administration is observed after 15 - 20 minutes, the maximum effect - after 2 - 3 hours after administration and is retained for 12 hours.
Applied with edema caused by circulatory failure, cirrhosis of the liver, nephrotic syndrome. In connection with potassium-sparing action, it is especially indicated for combined use simultaneously with thiazide diuretics, as well as in patients with digitalis glycoside intolerance, which is based on hypokalemia.
Assign inside by themselves and in combination with other diuretics. With independent use - 0.05 - 0.1 0.2 g per day (in 1 - 2 doses - after breakfast and lunch), with combination therapy - lower doses (for example, 0.025 g of triamteren and 0.0125 g of dichlothiazide) . Increase the dose gradually (to avoid too fast or profuse diuresis).
Usually take the drug daily.
When taking triamteren, nausea, vomiting, headache, and a decrease in blood pressure are possible in some cases.
Alkalosis, acidosis, urinary acid retention is not observed, but hyperkalemia is possible. With prolonged use, an increase in blood urea is possible. In these cases, it is recommended to take the drug not daily, but every other day and in smaller doses, alternating with the administration of diuretics of the benzothiadiazine group. Some patients develop hyperglycemia and hyperuricemia when using triamteren.
Release form: capsules on 0,05 g (50 mg) of a preparation.
Storage: List B.
Under the name "Triampur compositum" (Triampur compositum), tablets are produced in Germany containing 25 mg of triamteren and 12.5 mg of dihydrochlorothiazide (dichlothiazide). Assign with cardiac, renal edema, ascites, cirrhosis of the liver, etc.
Usually taken on an outpatient basis, 1 tablet 2 times a day (morning and afternoon after meals), in a hospital setting - 2 tablets 2 times a day.
Release form: tablets in packing of 50 pieces.
A similar domestic drug is produced under the name "Triamtezid" (Triamtezidum).