Medication Description: Triamteren (Triamterenum)
TRIAMTEREN (Triamterenum). 2, 4, 7-Triamino-6-phenylpteridine7
Synonyms: Pterofen, Amteren, Diutac, Diuteren, Dyren , Dyrenium, Dytac, Fluxinar, Jatropur, Neuuron, Noridyl, Pterofen, Reviten, Taturil, Teridin, Triamterene, Triarene, Trispan, Triteren, Triurene, Urocaudal et al.
Triamterene reduces the permeability of the cell membranes of the distal tubules to sodium ions and enhances their excretion in the urine without increasing the excretion of potassium ions. The secretion of potassium ions in the distal tubules decreases. The drug is able to reduce hypokalemia caused by benzothiadiazine derivatives, and enhance the diuretic effect of the latter.
The drug is rapidly absorbed; diuretic action after ingestion is noted after 15 - 20 minutes, the maximum effect - after 2 - 3 hours after ingestion and is maintained for 12 hours.
Apply with edema caused by circulatory failure, liver cirrhosis, nephrotic syndrome. In connection with the potassium-sparing effect, it is especially indicated for combined use simultaneously with thiazide diuretics, as well as in patients with symptoms of intolerance to digitalis glycosides, which is based on hypokalemia.
Assign inside alone and in combination with other diuretics. With self-administration - at 0.05 - 0.1 0.2 g per day (in 1 - 2 doses - after breakfast and lunch), with combination therapy - smaller doses (for example, 0.025 g of triamterene and 0.0125 g of dichlothiazide) . Increase the dose gradually (to avoid too fast or profuse diuresis).
Usually take the drug daily.
When taking triamteren possible in some cases, nausea, vomiting, headache, lowering blood pressure.
Alkalosis, acidosis, uric acid retention is not observed, but hyperkalemia is possible. With prolonged use may increase blood levels of urea. In these cases, it is recommended to take the drug not every day, but every other day and in smaller doses, alternating with taking diuretics of the benzothiadiazine group. In some patients with the use of triamterene, hyperglycemia and hyperuricemia develop.
Form release: capsules of 0.05 g (50 mg) of the drug.
Storage: List B.
Triampur Compositum (Triampur сompositum) in Germany produces tablets containing 25 mg of triamterene and 12.5 mg of dihydrochlorothiazide (dichlothiazide) each. Assign with cardiac, renal edema, ascites, cirrhosis of the liver, etc.
It is usually taken on an outpatient basis, 1 tablet 2 times a day (morning and afternoon after meals), and 2 tablets 2 times a day in the hospital.
Form release: pills in a package of 50 pieces.
A similar domestic drug is produced under the name "Triamtezid" (Triamtezidum).