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Description medications: sulfinpirazon (Sulfinpyrazone)

Sulfinpyrazone (Sulfinpyrazone) *. 1, 2-diphenyl-1, 4- [2- (phenylsulfinyl) ethyl] -3, 5-pirazolidindion.

Synonyms: Anturan, Anturan, Anturanil, Anturidin, Enturan , Pyrocard, Sulfazone, Sulfizone and others.

It is one of the metabolites butadiona (cm.).

Pronounced analgesic and anti-inflammatory action is not, but is an active urikozuricheskim means.

Applied for the treatment of gout. Via the kidneys increases the allocation of uric acid, especially in the first stage of treatment.

The drug is well absorbed. Duration of a single dose of 8 -. 12 hours Since the drug has no analgesic action is recommended at the same time appoint non-narcotic analgesics (phenylbutazone, or others).

Assign inside usually in a daily dose of 0.3 - 0.4 g of (2 - 4 doses). Take after a meal; it is desirable to drink milk.

Sulfinpirazon usually well tolerated, but may increase gastric ulcer and duodenal ulcer.

At the beginning of the treatment of gout perhaps more frequent attacks. In the appointment of treatment, you must first enter the body enough fluids and to hold urine alkalinization (sodium bicarbonate intake); with acidic urine may fall stones in the urinary tract.

Contraindications: peptic ulcer and duodenal ulcer, hypersensitivity to pyrazolone derivative (see Phenylbutazone.), Severe liver disease and kidney failure.

Keep in mind that small doses of salicylates weaken uricosuric action sulfinpirazona. The action of oral anticoagulants, oral antidiabetics, sulfonamides, penicillin drug enhances (see. Etamid).

Product: pills to 0.1 g in higher doses sulfinpirazon reduces platelet aggregation and adhesiveness. As antiagregatine means (. Cm antiplatelet agents) used in the form of pills to 0.2 g; appoint 1 - 4 2 tablets twice a day (800 mg daily). Apply in patients with myocardial infarction (start treatment within 4 weeks after a heart attack).