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Description of the medicine: Sulfinpyrazone (Sulfinpyrazone)

SULFINPIRAZONE (Sulfinpyrazone) *. 1, 2-Diphenyl-1, 4- [2- (phenylsulfinyl) ethyl] -3, 5-pyrazolidinedione.

Synonyms: Anturan, Anturan, Anturanil, Anturidin, Enturan, Pyrocard, Sulfazone, Sulfizone, etc.

Is one of butadione metabolites (see).

It does not have a pronounced analgesic and anti-inflammatory effect, but it is an active uricosuric agent.

Used to treat gout. It enhances the excretion of uric acid through the kidneys, especially in the first stage of treatment.

The drug is well absorbed. The duration of action of a single dose is 8-12 hours. Since the drug does not have an analgesic effect, it is recommended that non-narcotic analgesics (butadione or others) be prescribed simultaneously.

Assign inside usually in a daily dose of 0.3 - 0.4 g (in 2 to 4 doses). Take after meals; it is advisable to drink milk.

Sulfinpyrazone is generally well tolerated, but peptic ulcer and duodenal ulcer may be exacerbated.

At the beginning of the treatment of gout, an increase in seizures is possible. When prescribing a course of treatment, it is first necessary to introduce a sufficient amount of fluid into the body and alkalinize the urine (taking sodium bicarbonate); with an acidic reaction of urine, precipitation of stones in the urinary tract is possible.

Contraindications: peptic ulcer of the stomach and duodenum, hypersensitivity to pyrazolone derivatives (see Butadion), severe damage to the liver and kidneys.

It should be borne in mind that small doses of salicylates weaken the uricosuric effect of sulfinpyrazone. The effect of oral anticoagulants, oral antidiabetic agents, sulfonamides, penicillin is enhanced by the drug (see Ethamide).

Release form: tablets of 0.1 g. At higher doses, sulfinpyrazone reduces platelet aggregation and adhesion. As an antiplatelet agent (see. Antiplatelet agents) used in the form of tablets of 0.2 g; appoint 1 - 2 tablets 4 times a day (800 mg per day). Applied in patients after myocardial infarction (start treatment 4 weeks after a heart attack).