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Description of the medicine: Sulpiride (Sulpiride)

SULPIRIDE (Sulpiride).

N - (1-ethyl-2-pyrrolidinylmethyl) - 2-methoxy-5-sulfamoylbenzamide.

Synonyms: Dogmatil, Eglonil, Abilit, Digton, Dobren, Dogmalid, Dogmatil, Eglonyl, Eusulpid, Lisopiride, Megotyl, Miradon, Mirbanil, Modulan, Nivelan, Norestran, Omperan, Sulpiril, Suprium, Sursumid, Tepilil, Tepilil, Tepilcer, Ulpir, Vipral, etc.

Sulpiride is a sulfonylbenzamide derivative. The same group includes tiaprid and some other psychotropic drugs. In structure and certain pharmacological properties, sulpiride is also close to metoclopramide (see).

Like metoclopramide has an antiemetic effect; in addition, it has pharmacological properties characteristic of psychotropic drugs; It has a moderate antiserotonin and cataleptogenic effect, slightly weakens the stimulating effects of phenamine. It does not have a sedative effect, does not enhance the influence of barbiturates and analgesics. It does not have anticonvulsant activity.

Clinically, sulpiride is characterized as a drug with a "regulatory" effect on the central nervous system, in which moderate antipsychotic activity is combined with some antidepressant and stimulating properties. The antipsychotic effect may be due to the fact that the drug is an antagonist of dopamine receptors.

In psychiatric practice, sulpiride is used mainly in combination with other antipsychotics and antidepressants in conditions accompanied by lethargy, lethargy, and anergy, including hallucinatory-delusional and affective (mostly repressive) disorders. As an activating agent, it is used for sluggish schizophrenia. Assign inside 100 - 1000 mg per day. In severe cases, they begin with the introduction of the drug intramuscularly in doses from 100 to 800 mg per day.

Sulpiride is also used for migraines, dizziness, and behavioral disorders in children. In these cases, adults are prescribed by mouth 100 to 300 mg per day; children - 5 mg / kg per day.

In connection with the antiemetic and "cytoprotective" effect on the gastric mucosa (see Metoclopramide), as well as the "regulatory" effect on the nervous system, sulpiride is used for gastric ulcer and duodenal ulcer. The drug does not have a direct antacid effect. As a rule, they are used against the background of therapy with an appropriate diet. Usually prescribed orally, starting with a dose of 200 mg per day (100 mg 2 times a day - in the morning and in the evening), increasing the daily dose if necessary to 400 mg (200 mg 2 times a day).

The drug can be administered intramuscularly.

Sulpiride is usually well tolerated. However, there may be pyramidal disorders, agitation, sleep disturbances, increased blood pressure, menstrual irregularities; cases of galactorrhea and gynecomastia are described.

The drug is contraindicated in patients with pheochromocytoma and with severe hypertension. Sulpiride should not be prescribed to patients who are in a state of anxiety and psychomotor agitation.