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Medication Description: Sulpiride (Sulpiride)

SULPIRID (Sulpiride).

N - (1-ethyl-2-pyrrolidinylmethyl) -2-methoxy-5-sulphamoylbenzamide.

Synonyms: Dogmatil, Eglonil, Abilit, Digton, Dobren, Dogmalid, Dogmatil, Eglonyl, Eusulpid, Lisopiride, Megotyl, Miradon, Mirbanil, Modulan, Nivelan, Norestran, Omperan, Sulpiril, Suprium, Sursumid, Tepavil, your, your, yours, your, yours Ulpir, Vipral, etc.

Sulpiride is a sulfonylbenzamide derivative. This group includes tiaprid and some other psychotropic drugs. By structure and some pharmacological properties, sulpiride is also close to metoclopramide (see).

Like metoclopramide has an antiemetic effect; in addition, it has pharmacological properties characteristic of psychotropic drugs; it has a moderate antiserotonin and cataleptogenic effect, somewhat weakens the stimulating effects of phenamine. Sedative effect does not exert, does not enhance the effects of barbiturates and analgesics. Anticonvulsant activity does not possess.

Clinically, sulpiride is characterized as a drug with a "regulatory" effect on the CNS, in which moderate neuroleptic activity is combined with certain antidepressant and stimulating properties. The neuroleptic effect is probably due to the fact that the drug is an antagonist of dopamine receptors.

In psychiatric practice, sulpiride is used mainly in combination with other antipsychotics and antidepressants in conditions involving lethargy, lethargy, anergy, including with hallucinatory-delusional and affective (mostly repressive) disorders. As an activating agent, it is used for sluggish schizophrenia. Assign inside 100-1000 mg per day. In severe cases, start with the introduction of the drug intramuscularly in doses of 100 to 800 mg per day.

Sulpiride is also used for migraines, dizziness, behavioral disorders in children. In these cases, appoint adults inside 100 - 300 mg per day; children - 5 mg / kg per day.

In connection with the antiemetic and <cytoprotective> effects on the gastric mucosa (see Metoclopramide), as well as the <regulating> effect on the nervous system, sulpiride is used in gastric ulcer and duodenal ulcer. The drug does not have a direct antacid effect. As a rule, they are used against the background of therapy with an appropriate diet. Usually administered orally, starting with a dose of 200 mg per day (100 mg 2 times a day - in the morning and evening), increasing the daily dose to 400 mg if necessary (200 mg 2 times a day).

The drug can be administered intramuscularly.

Sulpiride is usually well tolerated. There may, however, be observed pyramidal disturbances, agitation, sleep disorders, increased blood pressure, menstrual disorders; described cases of galactorrhea and gynecomastia.

The drug is contraindicated in patients with pheochromocytoma and severe hypertension. It is not necessary to appoint sulpiride to the patients who are in a condition of alarm and psychomotor excitement.