Medication Description: Nicodinum
Pyridine-3-carboxylic (or nicotinic) acid oximethylamide:
Synonyms: Bilamid, Bilizorin, Bilocid, Cholamid, Coloton, Felosan, Isochol, Nicoform, Nikoform, etc.
White fine crystalline powder. Soluble in water, it is difficult - in alcohol.
Nicodine is a derivative of nicotinic acid amide and formaldehyde. It has a choleretic effect and at the same time it has bacteriostatic and bactericidal properties, which is partly due to the elimination of the formaldehyde part of the drug molecule in the body. Another part of the molecule (nicotinamide) has the properties of vitamin PP and has a positive effect on liver function.
Applied with cholecystitis and hepatocholecystitis, as well as with urinary tract infections and gastroenteritis. Most effective for infections caused by E. coli. It is especially advisable to appoint when combining inflammatory diseases of the biliary tract with gastritis and colitis. If necessary, take simultaneously with antibiotics. Nikodin does not exert an antispasmodic and analgesic action, therefore, for spasms and severe pains, the simultaneous use of antispasmodics and analgesics (promedol) is indicated.
Assign inside, at 0.5 - 1, 0 g (1 - 2 tablets) 3 - 4 times a day before eating half a glass of water is washed down.
For diseases involving febrile conditions, and with insufficient effectiveness of antibiotics, the dose of nicodine is increased to 8 g per day; after reducing the body temperature, the daily dose is reduced to 4 - 3 g, and then give 1, 0 - 0.5 g per day for 10 - 14 days. The course of treatment is repeated if necessary.
Nikodin is usually well tolerated. In some cases, with congestive forms of hepatitis, pain may increase, and with anacid gastritis, increased dyspeptic symptoms, to prevent them, simultaneous administration of diluted hydrochloric acid, gastric juice, or acidin-pepsin is recommended.
Form release: tablets of 0.5 g per pack of 10 pcs.
Storage: protected from light.