Description of the medicine: Henodiol (Chenodiol)
CHENODIOL (Chenodiol) *.
Chenodeoxycholic acid (Chenodesoxycholic acid).
Synonyms: Henofalk, Aholit, Chelobil, Chendal, Chenochol, Chenofalk, Chenolith, Cholanorm, Fluibil, Henohol, Quenobilan, Soluston, Ulbenid, etc.
White or slightly yellow crystalline powder. It is practically insoluble in water. Under physiological conditions, chenodeoxycholic (like ursodeoxycholic) acid is synthesized in large quantities in the human intestine. The ability of chenodiol to cause the dissolution of gallstones is associated with a decrease in the formation of cholesterol by inhibiting the microsomal enzyme involved in the synthesis of cholesterol.
It is used to dissolve small cholesterol stones of small size (with a diameter of up to 20 mm) that are not detectable during a routine X-ray examination, especially if there are contraindications for surgical intervention.
The daily dose for an adult is 15 mg per 1 kg of body weight (an average of 0.75 g).
Assign 1 capsule (250 mg) in the morning and 2 capsules (0.5 g) in the evening. The maximum daily dose is 1.5 g (6 capsules).
The duration of treatment depends on the size of the stones, the course of the disease, tolerance to the drug (6-48 weeks, up to a year or more). For relapse, take 1-2 capsules (0.25-0.5 g) for 3 months or more.
When using the drug, diarrhea is possible; in these cases, reduce the dose.
Contraindicated in stones found during routine x-ray examination, i.e. with a high content of calcium salts in them, with severe violations of bowel function, frequent biliary colic, chronic hepatitis, cirrhosis, cholangitis and other serious diseases of the liver and bile ducts, during pregnancy.
The drug should not be prescribed simultaneously with antacids (containing aluminum hydroxide) and anion exchangers (cholestyramine) in order to avoid deterioration of absorption.
Release form: 0.25 g capsules in a package of 100 pieces.