Description of the medicine: Chenodiol (Chenodiol)
HENODIOL (Chenodiol) *.
Chenodeoxycholic acid (Chenodesoxycholic acid).
Synonyms: Chenofalk, Aholit, Chelobil, Chendal, Chenochol, Chenofalk, Chenolith, Cholanorm, Fluibil, Henohol, Quenobilan, Soluston, Ulbenid and others.
White or slightly yellow crystalline powder. Almost nerastvorim in the water. Under physiological conditions, chenodeoxycholic (like ursodeoxycholic) acid is synthesized in large quantities in the human intestine. The ability of chenodiol to cause the dissolution of gallstones is associated with a decrease in the formation of cholesterol by inhibiting the microsomal enzyme involved in the synthesis of cholesterol.
Uncoated cholesterol stones of small size (up to 20 mm in diameter) are used to dissolve, which are not detectable during routine radiographic examination, especially if there are contraindications to surgical intervention.
The daily dose for an adult is 15 mg per 1 kg of body weight (an average of 0.75 g).
Assign 1 capsule (250 mg) in the morning and 2 capsules (0.5 g) in the evening. The maximum daily dose of 1, 5 g (6 capsules).
The duration of treatment depends on the size of the stones, the course of the disease, the tolerability of the drug (6-48 weeks, up to a year or more). If relapsed, take 1-2 capsules (0.25-0.5 g) for 3 months or more.
When using the drug, diarrhea is possible; In these cases, reduce the dose.
Contraindicated with stones detected during routine radiographic examination, i.e. With a high content of calcium salts in them, with severe bowel disturbances, frequent biliary colic, chronic hepatitis, liver cirrhosis, cholangitis and other serious diseases of the liver and bile ducts, during pregnancy.
The drug should not be administered simultaneously with antacids (containing aluminum hydroxide) and anion exchangers (cholestyramine) in order to avoid deterioration of absorption.
Form release: capsules of 0.25 grams in a package of 100 pieces.