Medication Description: Chenodiol
Chenodeoxycholic acid (Chenodesoxycholic acid).
Synonyms: Henofalk, Aholit, Chelobil, Chendal, Chenochol, Chenofalk, Chenolith, Cholanorm, Fluibil, Henohol, Quenobilan, Soluston, Ulbenid, etc.
White or slightly yellow crystalline powder. Practically insoluble in water. Under physiological conditions, chenodeoxycholic (like ursodeoxycholic) acid is synthesized in large quantities in the human intestine. The ability of henodiol to cause dissolution of gallstones is associated with a decrease in the formation of cholesterol by inhibiting the microsomal enzyme involved in the synthesis of cholesterol.
Used for dissolving unordered cholesterol stones of small size (diameter up to 20 mm), which are not detectable during normal X-ray examination, especially if there are contraindications to surgical intervention.
The daily dose for an adult is 15 mg per 1 kg of body weight (average 0.75 g).
Assign 1 capsule (250 mg) in the morning and 2 capsules (0.5 g) in the evening. The maximum daily dose of 1, 5 g (6 capsules).
The duration of treatment depends on the size of the stones, the course of the disease, the tolerance of the drug (6-48 weeks, up to a year or more). When relapse take 1 - 2 capsules (0.25 - 0.5 g) for 3 months or more.
When using the drug is possible diarrhea; in these cases, reduce the dose.
Contraindicated in stones, detected by the usual X-ray examination, i.e. with a high content of calcium salts in them, with pronounced violations of bowel function, frequent biliary colic, chronic hepatitis, cirrhosis of the liver, cholangitis and other serious diseases of the liver and bile ducts, during pregnancy.
The drug should not be administered simultaneously with antacids (containing aluminum hydroxide) and anion exchangers (cholestyramine) in order to avoid deterioration of absorption.
Product form: 0.25 g capsules in a package of 100 pieces.