Description of the medicine: Chlozepid (Chlozepidum)
CHLOSEPID (Chlozepidum). 7-Chloro-2-methylamino-5-phenyl-ZN-1, 4-benzodiazepine-4-oxide.
Synonyms: Napoton, Chlordiazepoxide, Elenium, Ansiacal, Benzodiapin, Chlordiazepoxidum, Chlordiazepoxide, Decadil, Droxol, Elenium, Equinbral, Labiton, Librium, Lixin, Napoton, Novosed, Radepur, Sonimen, Timosin, others.
White or light yellow crystalline powder. It is practically insoluble in water, it is hardly soluble in alcohol.
Chlordiazepoxide (librium, chlozepide) was the first representative of tranquilizers in the benzodiazepine group. Currently, this group includes a number of more effective drugs, but chlordiazepoxide has not completely lost its significance.
Chlozepide has a calming effect on the central nervous system, causes muscle relaxation, has anticonvulsant activity, potentiates the effect of sleeping pills and analgesics, and has a moderate hypnotic effect (usually manifested with continuous use only in the first 3-5 days).
A characteristic feature of chlozepide is the ability to suppress a sense of fear, anxiety, tension in neurotic conditions. It has no antipsychotic effect. In large doses, it can reduce psychomotor agitation.
Chlozepide pharmacokinetically (like other tranquilizers of this series) is characterized by relatively rapid absorption after oral administration. The peak plasma concentration is observed after 2 to 4 hours; half-life of 8 to 10 hours. It is allocated mainly by the kidneys. Penetrates through the placental barrier.
Chlozepide is used for neurotic conditions accompanied by anxiety, agitation, tension, increased irritability, and insomnia. It can be used for organ neurosis (functional neurosis of the cardiovascular system, gastrointestinal tract), migraine, menopause disorders, etc.
In anesthetic practice, it can be used for preoperative preparation of patients in the postoperative period.
In connection with the ability to lower muscle tone, it is also used for spastic conditions associated with damage to the brain and spinal cord (including impaired movement in children), as well as myositis, arthritis, bursitis and other diseases accompanied by muscle tension.
It is also prescribed for eczema and other skin diseases accompanied by itching, irritability.
In psychiatric practice, chlozepide is sometimes used in borderline conditions with phenomena of obsession, anxiety, fear, affective tension, with shallow depressive and hypochondriacal conditions, including those associated with diencephalic pathology, as well as in the complex treatment of patients with epilepsy and for the treatment of withdrawal syndrome with alcoholism addiction.
Doses of chlozepide are selected individually: usually prescribed for adults (by mouth), starting from 0.005 - 0.01 g (5 - 10 mg) per day; if necessary, the dose is gradually increased by 5 to 10 mg per day to a daily dose of 30 to 50 mg (in 3 to 4 doses).