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Medication Description: Chlozepidum

HLOZEPID (Chlozepidum). 7-Chloro-2-methylamino-5-phenyl-3H-1; 4-benzodiazepine-4-oxide.

Synonyms: Napoton, Chlordiazepoxide, Elenium, Ansiacal, Benzodiapin, Chlordiazepoxidum, Chlordiazepoxide, Decadil, Droxol, Elenium, Equinbral, Labiton, Librium, Lixin, Napoton, Novosed, Radepur, Sonimen, Tim Synthesis, Librium, Lixin, Napoton

White or light yellow crystalline powder. Practically insoluble in water, difficult to dissolve in alcohol.

Chlordiazepoxide (librium, hlozepid) was the first representative of tranquilizers in the benzodiazepine group. Currently, this group includes a number of more effective drugs, but chlordiazepoxide has not completely lost its value.

Chlozepid has a calming effect on the central nervous system, causes muscle relaxation, has anticonvulsant activity, potentiates the effect of hypnotics and analgesics, has a moderate hypnotic effect (usually manifested with continuous use only in the first 3 - 5 days).

A characteristic feature of hlozepida is the ability to suppress the feeling of fear, anxiety, tension in neurotic states. Antipsychotic action does not have. In large doses, it can reduce psychomotor agitation.

Pharmacokinetic hlozepid (like other tranquilizers of this series) is characterized by relatively rapid absorbability after oral administration. The peak concentration in the blood plasma is observed in 2 to 4 hours; the half-life period is 8–10 h. It is mainly excreted by the kidneys. It penetrates the placental barrier.

Apply hlozepid with neurotic states, accompanied by anxiety, agitation, tension, increased irritability, insomnia. It can be used for organ neurosis (functional neurosis of the cardiovascular system, gastrointestinal tract), migraine, menopausal disorders, etc.

In anesthesia practice can be used for preoperative preparation of patients and in the postoperative period.

In connection with the ability to lower muscle tone, they are also used for spastic conditions associated with lesions of the brain and spinal cord (including movement disorders in children), as well as myositis, arthritis, bursitis and other diseases accompanied by muscle tension.

Appoint also with eczema and other skin diseases, accompanied by itching, irritability.

In psychiatric practice, hlozepid is sometimes used in borderline states with obsession, anxiety, fear, affective tension, in shallow depressive and hypochondriacal conditions, including those associated with diencephalic pathology, as well as in complex treatment of patients with epilepsy and for the treatment of withdrawal syndrome in alcoholism and addiction.

Doses of hlozepida pick up individually: usually appoint adults (inside), ranging from 0.005 - 0.01 g (5-10 mg) per day; if necessary, gradually increase the dose by 5 to 10 mg per day to a daily dose of 30 to 50 mg (in 3 to 4 doses).