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Description medications: hlozepida (Chlozepidum)

Hlozepida (Chlozepidum). 7-Chloro-2-methylamino-5-phenyl-SH-1, 4- benzodiazepine-4-oxide.

Synonyms: Napoton, chlordiazepoxide, elenium, Ansiacal, Benzodiapin, Chlordiazepoxidum, Chlordiazepoxide , Decadil, Droxol, Elenium, Equinbral, Labiton, Librium, Lixin, Napoton, Novosed, Radepur, Sonimen, Timosin, Viansin and others.

White or light yellow crystalline powder. Practically insoluble in water, soluble in alcohol difficult.

Chlordiazepoxide (Librium, hlozepida) was the first member of the benzodiazepine tranquilizers in the group. Currently, this group includes a number of more effective drugs, chlordiazepoxide but its significance is not totally lost.

Hlozepida has a calming effect on the central nervous system, causing muscle relaxation, has anticonvulsant activity, potentiates the action of hypnotics and analgesics, has a mild hypnotic effect (usually manifested in the continuous application of only the first 3 - 5 days).

A characteristic feature is the ability to suppress hlozepida feelings of fear, anxiety, stress in neurotic states. Antipsychotic action is not. In large doses, can reduce agitation.

Pharmacokinetic hlozepida (as well as other tranquilizers in this series) is characterized by relatively rapid absorbability after oral administration. Peak plasma concentrations observed after 2 - 4 hours; half-life 8 - 10 hours. Provided mainly kidneys. It penetrates through the placental barrier.

Apply hlozepida with neurotic conditions, accompanied by anxiety, agitation, tension, increased irritability, insomnia. It may be used in organ neuroses (functional neuroses cardiovascular system, gastrointestinal tract), migraine, and other menopausal disorders.

In practice anesthetics can be used for patients with preoperative and postoperative period.

In connection with the ability to reduce muscle tone and are used in spastic conditions associated with brain and spinal cord lesions (including the movement disorders in children), as well as myositis, arthritis, bursitis and other diseases accompanied by muscle tension.

Assign also for eczema and other skin diseases accompanied by itching, irritability.

In psychiatric practice hlozepida sometimes used in border states with symptoms of obsession, anxiety, fear, emotional tension, with shallow depression, and hypochondriacal conditions, including those associated with diencephalic pathology, as well as in treatment of patients with epilepsy and for the treatment of abstinence syndrome in alcoholism and addiction.

Doses are selected individually hlozepida: adult is usually administered (oral), starting from 0.005 - 0.01 g of (5 - 10 mg) per day; if necessary to gradually increase the dose of 5 - 10 mg per day up to a daily dose of 30 - 50 mg (3 - 4 divided doses).