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Medication Description: Desaminooxytocin (Desaminooxytocinum)

DEZAMINOOXITOCIN (Desaminooxytocinum).

Synonyms: Sandopart, Demoxytocin, Demoxytocinum, Sandopart.

A synthetic polypeptide that differs from oxytocin in that cysteine ​​at position 1 is deaminated.

White amorphous powder. It is difficult to dissolve in water and alcohol.

The action of desaminooxytocin is close to oxytocin, but is resistant to the enzymes that destroy oxytocin. The drug is well absorbed through the mucous membrane of the oral cavity, does not decompose by enzymes of saliva, therefore it can be used transbukkalno.

The specific activity of desaminooxytocin (as well as oxytocin) is expressed in units of action (U or IU) and is determined biologically by reducing the isolated horn of the rat uterus.

Vasopressor action of the drug does not have that allows you to assign it to patients suffering from hypertension.

Used to initiate and enhance labor, accelerate the involution of the uterus in the postpartum period and stimulate lactation.

Take in pill form. Each tablet contains 50 IU of the drug. A pill is placed on the cheek alternately on the right and left sides and held in the mouth (without chewing or swallowing) until completely absorbed (about 30 minutes).

For labor induction and stimulation of labor, tablets are prescribed again with an interval of 30 minutes. The number of tablets varies depending on the particular case. Typically, the maximum dose for the excitation and stimulation of labor is 500 U (10 tablets), in rare cases - 900 U. With the appearance of regular, strong contractions, the following single doses of deaminooxycitocin halve (1/2 tablet) or increase the interval between injections (1 h). If there is no effect, the drug can be taken again after 24 hours.

During the use of de-aminooxytocin, other oxytocic substances should not be administered.

To stimulate lactation prescribed from the 2nd to the 6th day of the postpartum period of 25 - 50 IU (1/2 - 1 tablet) for 5 minutes before feeding the child 2 to 4 times a day.

Contraindications are the same as for oxytocin.

Form release: tablets containing 50 U, in orange glass banks of 10 pieces.

Storage: List B. In a dry, dark place at a temperature not higher than + 25 C.