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Description of the medicine: Desaminooxytocin (Desaminooxytocinum)

DESAMINOOXYTOCIN (Desaminooxytocinum).

Synonyms: Sandopart, Demoxytocin, Demoxytocinum, Sandopart.

A synthetic polypeptide that differs from oxytocin in that the cysteine ​​at position 1 is deaminated.

White amorphous powder. It is soluble in water and alcohol.

According to the action, desaminooxytocin is close to oxytocin, but resistant to enzymes that destroy oxytocin. The drug is well absorbed through the oral mucosa, is not decomposed by saliva enzymes, therefore, it can be used buccally.

The specific activity of desaminooxytocin (as well as oxytocin) is expressed in units of action (ED or ME) and is determined biologically by reducing the isolated rat uterine horn.

The drug does not have a vasopressor effect, which allows it to be prescribed to patients suffering from hypertension.

They are used to excite and enhance labor, accelerate uterine involution in the postpartum period and stimulate lactation.

Take in pill form. Each tablet contains 50 units of the drug. The tablet is placed on the cheek alternately on the right and left sides and held in the mouth (without chewing and not swallowing) until completely resorbed (about 30 minutes).

To induce labor and stimulate labor, tablets are prescribed again with an interval of 30 minutes. The number of tablets varies depending on the characteristics of the case. Typically, the maximum dose for excitation and stimulation of labor is 500 units (10 tablets), in rare cases - 900 units. With the appearance of regular, strong contractions, the following single doses of desaminooxytocin are halved (1/2 tablet) or the interval between administrations is increased (1 h). In the absence of effect, the drug can be taken again after 24 hours.

During the use of desaminooxytocin, other oxytocic substances should not be administered.

To stimulate lactation, they are prescribed from 25 to 50 units (1/2 to 1 tablet) from the 2nd to the 6th day of the postpartum period 5 minutes before feeding the baby 2 to 4 times a day.

Contraindications are the same as for oxytocin.

Release form: tablets containing 50 units, in orange glass jars of 10 pieces.

Storage: List B. In a dry, dark place at a temperature of no higher than + 25 C.