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Description of the medicine: Somatotropin (Somatotropinum humanum)

SOMATOTROPIN (human) (Somatotropinum humanum).

Hormone of the anterior pituitary gland of a person.

Synonyms: Growth Hormone, Somatropin, Humatrop, Asellacrin, Crescormon, Genotropin, Humatrop, Nanormon, Somatonorm, STH, Somatropin.

It is a polypeptide consisting of 191 amino acid residues.

It has an anabolic effect, has a positive effect on mineral metabolism, causes an increase in growth and body weight with dwarfism associated with growth hormone deficiency.

In the past, somatropin for injection, secreted from the pituitary gland, was produced for medical use.

Recently (1998), this drug was excluded from the nomenclature and replaced with somatotropin preparations obtained by genetic engineering methods (Sizen, Genotropin, Humatrop, Norditropin, etc.).

Indications for the use of growth hormone preparations are disorders of the body's development associated with growth hormone deficiency (pituitary dwarfism, pituitary dwarfism).

Devices of this group are contraindicated in malignant neoplasms.

Saizen

Somatotropic hormone obtained by genetic engineering (using animal mammalian cells).

It causes an increase in growth and body weight (mainly in patients with stunted growth associated with impaired secretion of endogenous growth hormone).

Indications for use - see Somatotropin.

Intramuscularly or subcutaneously. Daily apply at the rate of 12 PIECES (ME) per 1 sq. M of body surface (0.6 PIECES / kg). In the absence of effect, the dose is increased to 20 PIECES / sq.m (or 0.8 PIECES / kg).

When administered intramuscularly, the calculated weekly dose is divided into 3 single injections (4 U / m2 or 0.2 U / kg) and administered every other day (usually in the evening).

With subcutaneous administration, the weekly dose is divided into 6-7 single doses.

The treatment is carried out for a long time (under careful clinical and laboratory control).

There are indications that after a 12-month administration of Sizen there is a significant increase in the growth rate of the body of children.

Release form: lyophilized powder in bottles of 4 or 10 IU.

Storage: at a temperature of +2 to +8 C (in the refrigerator).

Genotropin (Genotropin).

A variety of recombinant (obtained by genetic engineering using Escherichia coli) somatotropin.

Indications for use - see Somatotropin.

Enter under the skin. The dose is selected individually. Usually used at the rate of 12-16 IU per 1 sq. M of body surface or 0.5-0.7 mg per 1 kg of body weight per week. This dose is divided into 6-7 injections (1 time per day).

Release form: special two-section cartridges (cartridges) containing 16 IU of lyophilized somatotropin (genotropin) powder in one section and a solvent in the other. Enter with a special syringe.

Humatrop (Humatrop) is available in bottles of 4 IU (lyophilized powder for injection) and 18 and 36 IU in a special dosage form (cartridges of 3 ml).

Norditropin (Norditropin) - in bottles of 12 and 24 IU.

Indications for use - see Saizen.