Medication Description: Danazol (Danazol)
DANAZOL (Danazol). 17 a -Pregna-2, 4-diene-20-yo (2, 3-) isoxazol-17-ol.
Synonyms: Danoval, Bonzol, Cyclomen, Danocrine, Danogar, Danokrin, Danol, Danoval, Ladogar, Lodogal, etc.
The drug inhibits the release of pituitary gonadotropic hormones (luteinizing and follicle-stimulating). In large doses, it has a moderate androgenic and anabolic effect.
In connection with the antigonadotropic effect, they are used in the treatment of endometriosis with concomitant infertility, benign breast tumors (fibrocystic mastitis, etc.), premenstrual syndrome, gynecomastia and other diseases for which suppression of gonadotropins secretion is indicated.
Assign inside the capsules.
The dose for adults ranges from 200 to 800 mg per day (in 2 - 4 doses). Doses and terms of treatment are individualized depending on the disease, the effectiveness of therapy, the tolerability of the drug.
Adolescents with premature puberty are prescribed 100 - 400 mg per day.
The use of danazol may cause nausea, dizziness, headache, alopecia, skin rash, acne, skin greasiness, fluid retention, moderate hirsutism, coarsening of the voice and other virilization phenomena.
Contraindicated in pregnancy, breastfeeding, porphyria. Caution should be observed in the treatment of patients with heart and kidney failure, diabetes.
Do not assign danazol simultaneously with anticonvulsants and anticoagulants (possibly increasing the effect).
Form release: capsules containing 0.1 and 0.2 g (100 or 200 mg) of danazol.
Storage: List B.