Description of the medicine: Danazol (Danazol)
DANAZOL (Danazol). 17 a -Pregna-2, 4-dien-20-ino (2,3-) isoxazole-17-ol.
Synonyms: Danowal, Bonzol, Cyclomen, Danocrine, Danogar, Danokrin, Danol, Danoval, Ladogar, Lodogal, etc.
The drug inhibits the release of pituitary gonadotropic hormones (luteinizing and follicle-stimulating). In large doses, it has a moderate androgenic and anabolic effect.
In connection with the antigonadotropic effect, it is used in the treatment of endometriosis with concomitant infertility, benign neoplasms of the mammary gland (fibrocystic mastitis, etc.), premenstrual syndrome, gynecomastia, and other diseases in which suppression of gonadotropin secretion is indicated.
Assign inside capsules.
The dose for adults is from 200 to 800 mg per day (in 2 to 4 doses). Doses and periods of treatment are individualized depending on the disease, the effectiveness of therapy, and tolerability of the drug.
Adolescents with premature puberty are prescribed 100 to 400 mg per day.
When using danazol, nausea, dizziness, headache, alopecia, skin rash, acne, skin greasy, fluid retention, moderate hirsutism, voice coarsening and other virilization phenomena are possible.
Contraindicated in pregnancy, breast-feeding, porphyria. Caution should be observed in the treatment of patients with heart and kidney failure, diabetes.
Danazol should not be prescribed simultaneously with anticonvulsants and anticoagulants (an effect may be enhanced).
Release form: capsules containing 0.1 and 0.2 g (100 or 200 mg) of danazol.
Storage: List B.