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Description medications: Tireoidin (Thyreoidinum)

Thyroidin (Thyreoidinum).

Hormonal drug, derived from the dried defatted thyroid glands slaughter cattle.

Synonyms: Thyranon, Thyroid, Thyrotan.

The powder is a yellow-gray in color with a mild odor characteristic of dried animal tissues. Insoluble in water, alcohol and other solvents.

It possesses biological activity of thyroid hormone.

Standardizes the content of organically bound iodine (0.17 to 023%).

Action thyroidin due to the presence in it of two hormones: thyroxine and triiodothyronine (in the body are both levorotatory isomers).

Chemically thyroxine triiodothyronine differs from the presence in the molecule one additional iodine atom.

Both hormones have a similar multifaceted effect on the body, increase tissue oxygen demand, increase energy processes, stimulate growth and differentiation of tissues, affect the functional state of the nervous and cardiovascular systems, liver, kidneys and other organs and systems that enhance the absorption of glucose and its recycling. The effect of thyroid hormones may vary depending on the dose. Thus, a small dose of thyroxine have anabolic effects, the large doses lead to increased protein degradation. In large doses, thyroid hormones inhibit the pituitary thyroid-stimulating activity.

Triiodothyronine 3 - 5 times more potent than thyroxine, and is faster, since less blood proteins binds, preferably transported in the blood in a free form and will penetrate through the cell membrane. Triiodothyronine latency period is 4 - 8 hours and thyroxine 24 - 48 hours.

Currently produced synthetically triiodothyronine; it is used as a standalone treatment medication (see. triiodothyronine hydrochloride).

Tireoidin and triiodothyronine appoint (in relatively small doses) in low thyroid function and higher doses (not causing hyperthyroidism, but sufficient to suppress the activity of thyrotrophic) - at excessive thyrotrophic pituitary function. The main indications for their use are primary hypothyroidism and myxedema, cretinism, cerebral pituitary disease that occur with hypothyroidism, obesity with symptoms of hypothyroidism, endemic and sporadic goiter, thyroid cancer.

Tireoidin has cholesterol-lowering effect in patients with atherosclerosis. The mechanism of action is associated apparently with the stimulation of cholesterol catabolism. Clinical application thyroidin for this purpose, however, is limited because of the possible increase in patients with angina.

Assign tireoidin inside. Doses should be carefully indivilualizirovatsya considering the age of the patient, the nature and course of the disease. Is the interior in the first half of the day after a meal.