Description medications: Merkazolil (Mercazolilum)

Mercazolilum (Mercazolilum). 1-Methyl-2-mercaptoimidazole.

Synonyms: Tiamazol, Antiroid, Basolan, Danantizol, Favistan , Mercazole, Methimazole, Methothyrin, Tapazole, Thiamazole, Thycapzol, Thymidazol and others.

White or yellow crystalline powder with low specific smell and bitter taste. Easily soluble in water (1: 7, 5) and ethanol (1:10).

It is a synthetic antithyroid (tireostaticheskim) substance. As with other substances of this group, it causes a decrease in the synthesis of thyroxine in the thyroid gland, thus has a specific therapeutic effect in its hyperfunction. Like other antithyroid substances also lowers the basal metabolic rate.

The drug accelerates the removal of the thyroid iodide inhibits the activity of enzymes involved in the oxidation of iodide to iodine, which leads to inhibition of thyroglobulin iodination and the delay in turning diyodtirozina thyroxine. In addition, violation of the synthesis of thyroxine methylthiouracil can depend on reaction with free iodine in the thyroid gland formed of iodides.

Apply with diffuse toxic goiter (mild, moderate and severe forms).

Assign inside after eating: the light and medium forms of hyperthyroidism - 0,005 g 3 - 4 times a day in severe form - at 0.01 g 3 - 4 times a day.

After remission (after 3 - 6 weeks) daily dose is reduced every 5 - 10 days 0,005 - 0.01 grams and gradually pick up minimal maintenance doses (0.005 g 1 time per day, or every other day 1 every 3 days) to the obtaining lasting therapeutic effect.

Too early termination of treatment relapse is possible.

There are a combination of the feasibility of data merkazolila with lithium carbonate.

Higher doses for adults inside: single 0.01 grams daily 0.04 g

Merkazolil generally well tolerated at therapeutic doses. It should, however, be used under the supervision of a doctor, once a week is necessary to produce a study of the blood, as in some cases, may develop leukopenia; also possible nausea, vomiting, abnormal liver function, goitrogenic effects, drug-induced hypothyroidism, skin rash, joint pain. In developing side effects, reduce the dose or stop taking the drug further.

In patients receiving Mercazolilum in preparation for surgery, may increase bleeding thyroid, therefore, reached remission or significant improvement in the condition of the patient, Mercazolilum cancel, appointed iodine preparations; operation is carried out after 2 - 3 weeks.

Contraindicated for pregnant women, breast-feeding, with severe leukopenia and granulocytopenia, nodular goiter (except heavy progressive diseases for which temporarily exclude the possibility of the operation).

Do not combine with merkazolila receiving drugs that can cause leucopenia (Amidopyrine and its analogs, sulfonamides, etc.).

Product: pills to 0,005 g

Storage: List B. In dry, dark place.