Description of the medicine: Mercazolil (Mercazolilum)
MERCASOLIL (Mercazolilum). 1-Methyl-2-mercaptoimidazole.
Synonyms: Tiamazole, Antiroid, Basolan, Danantizol, Favistan, Mercazole, Methimazole, Methothyrin, Tapazole, Thiamazole, Thycapzol, Thymidazol, etc.
A white or yellowish crystalline powder with a faint specific odor and a bitter taste. Easily soluble in water (1: 7, 5) and alcohol (1:10).
It is a synthetic antithyroid (thyreostatic) substance. Like other substances of this group, it causes a decrease in the synthesis of thyroxine in the thyroid gland, due to which it has a specific therapeutic effect with its hyperfunction. Like other antithyroid substances, it also lowers the basal metabolic rate.
The drug accelerates the excretion of iodides from the thyroid gland, inhibits the activity of enzyme systems involved in the oxidation of iodides to iodine, which leads to inhibition of thyroglobulin iodination and a delay in the conversion of diiodotyrosine to thyroxine. In addition, a violation of the synthesis of thyroxine may depend on the reaction of methylthiouracil with free iodine, which is formed in the thyroid gland from iodides.
Applied with diffuse toxic goiter (mild, moderate and severe).
Assign inside after a meal: in mild and moderate forms of thyrotoxicosis - 0.005 g 3-4 times a day, in severe form - 0.01 g 3-4 times a day.
After the onset of remission (after 3-6 weeks), the daily dose is reduced every 5-10 days by 0.005-0.01 g and the minimum maintenance doses are gradually selected (0.005 g once a day, every other day or once every 3 days) to obtaining a stable therapeutic effect.
If the treatment is stopped too early, a relapse of the disease is possible.
There is evidence of the advisability of combining mercazolyl with lithium carbonate.
Higher doses for adults inside: single 0.01 g daily 0.04 g.
Merkazolil is usually well tolerated in therapeutic doses. It should, however, be used under the supervision of a doctor, once a week it is necessary to conduct a blood test, as in some cases leukopenia may develop; nausea, vomiting, impaired liver function, goiter effect, drug hypothyroidism, skin rash, joint pain are also possible. With the development of side effects, reduce the dose or stop further administration of the drug.
In patients receiving mercazolil in preparation for surgery, an increase in thyroid hemorrhage is possible, therefore, having achieved remission or a significant improvement in the patient's condition, mercazolil is canceled, iodine preparations are prescribed; the operation is performed after 2 to 3 weeks.
It is contraindicated for pregnant women, during breast-feeding, with severe leukopenia and granulocytopenia, nodular forms of goiter (with the exception of severe progressive diseases, in which the possibility of surgery is temporarily excluded).
You should not combine taking mercazolil with drugs that can cause leukopenia (amidopyrine and its analogues, sulfonamides, etc.).
Release form: tablets on 0,005 g.
Storage: List B. In a dry, dark place.