Description of drug: Parathyroidin for injection (Parathyreodinum pro injectionibus)

PARATHYREIDIN FOR INJECTIONS (Parathyreodinum pro injectionibus).

Synonyms: Parathyreocrinum, Parathormon.

Hormonal preparation obtained from parathyroid glands of cattle.

Weakly opalescent liquid of light brown color with the smell of phenol (preservative); PH 2, 5 - 3, 0.

It has the property of increasing the calcium content in the blood and eliminating the tetanus syndrome associated with deficiency of the parathyroid glands. Biological activity is established by the ability to increase the calcium content in the blood in dogs and expressed in units of action (ED). In 1 ml contains 20 units.

They are used as a means for preventing tetany caused by hypocalcemia in hypoparathyroidism.

Enter intramuscularly or subcutaneously for 1 - 2 ml 1 - 2 times a day, every day or every other day.

To eliminate an acute attack of tetanus, adults are given 2-4 ml each, children under 1 year old with 0.25-0.5 ml, 2-5 with 0.5-1.5 ml, 6-12 with 1-5 years, 2, 0 ml every 2 to 3 h until the cramping ceases completely. At the same time, 5-10 ml of 10% calcium chloride solution is administered intravenously, or 1 table (dessert) spoon is prescribed inside of a 5% solution of calcium chloride 5-6 times a day. Outside the attack, adults take 1 to 2 ml daily or every other day.

Higher doses for adults: single 5 ml, daily 15 ml.

Treatment with parathyroidin should be monitored by the concentration of calcium in the blood, which should not exceed 12 mg% (in the International System of Units SI: mmol / L - 0.294 recalculation factor).

With long-term treatment with parathyroidin, its effectiveness is reduced because of the developing resistance in patients with it. Therefore, after eliminating hypocalcemia, the patient should prescribe vitamin D preparations and a diet high in calcium and low in phosphorus.

When overdose of parathyroidin and hypercalcemia, general weakness and lethargy, vomiting and diarrhea are observed. In this case, reduce the dose of the drug and the amount of calcium administered. If you do not take timely measures, you can develop more severe violations (severe adynamia, muscle atony, lethargy) right up to coma.

Contraindicated with elevated levels of calcium in the blood.

Product: in ampoules of 1 ml.

Storage: List B. In a dark place at a temperature of + 1 to +10 C.

Currently, the drug is considered obsolete and has no wide application.