Medication description: Parathyroidin for injection (Parathyreodinum pro injectionibus)
PARATYREOIDINE FOR INJECTION (Parathyreodinum pro injectionibus).
Synonyms: Parathyreocrinum, Parathormon.
Hormonal drug derived from the parathyroid glands of cattle.
Weak opalescent liquid light brown in color with the smell of phenol (preservative); pH 2, 5 - 3, 0.
It has the property of increasing the calcium content in the blood and eliminating the syndrome of tetany associated with insufficiency of the parathyroid glands. Biological activity is determined by the ability to increase the calcium content in the blood of dogs and is expressed in units of action (ED). 1 ml contains 20 U.
Used as a means to prevent tetany caused by hypocalcemia with hypoparathyroidism.
Injected intramuscularly or subcutaneously in 1 to 2 ml 1 to 2 times a day, every day or every other day.
To eliminate an acute attack of tetany, adults are given 2 - 4 ml, children under 1 year old - 0.25 - 0.5 ml, 2 - 5 years - 0.5 - 1, 5 ml, 6 - 12 years - 1, 5 - 2, 0 ml every 2 to 3 hours until complete cessation of seizures. At the same time, 5-10 ml of a 10% solution of calcium chloride is administered intravenously or administered orally in 1 tablespoon (dessert) spoon of a 5% solution of calcium chloride 5-6 times a day. Outside the attack, adults take 1 - 2 ml daily or every other day.
Higher doses for adults: single 5 ml, 15 ml daily.
Treatment with parathyroidoid should be carried out under the control of the concentration of calcium in the blood, which should not exceed 12 mg% (in the International System of Units SI: mmol / L - a recalculation factor of 0.249).
With long-term treatment with parathyroidin, its effectiveness is reduced due to developing resistance to it in patients. Therefore, after the elimination of hypocalcemia, the patient should be prescribed preparations of vitamin D and a diet high in calcium and low in phosphorus.
With an overdose of parathyroid and hypercalcemia, there is general weakness and lethargy, vomiting and diarrhea. In this case, reduce the dose of the drug and the amount of calcium. If you do not take timely measures, then more severe disorders (severe adynamia, muscular atony, lethargy) can develop up to coma.
Contraindicated with elevated levels of calcium in the blood.
Product: in 1 ml ampoules.
Storage: List B. In a dark place at a temperature of from + 1 to + 10 C.
Currently, the drug is considered obsolete and not widely used.