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Description of the medicine: Parathyroidin injection (Parathyreodinum pro injectionibus)

PARATHYREOIDIN FOR INJECTION (Parathyreodinum pro injectionibus).

Synonyms: Parathyreocrinum, Parathormon.

A hormonal drug derived from the parathyroid glands of cattle.

Lightly opalescent liquid, light brown in color with the smell of phenol (preservative); pH 2, 5 - 3, 0.

It has the property of increasing the calcium content in the blood and eliminating tetany syndrome associated with parathyroid insufficiency. Biological activity is determined by the ability to increase blood calcium in dogs and is expressed in units of action (U). 1 ml contains 20 units.

Used as a means of preventing tetany due to hypocalcemia in hypoparathyroidism.

Intramuscularly or subcutaneously, 1 to 2 ml is administered 1 to 2 times a day, daily or every other day.

To eliminate an acute attack of tetany, adults are given 2 to 4 ml, children up to 1 year old - 0.25 - 0.5 ml, 2 - 5 years old - 0.5 - 1, 5 ml, 6 - 12 years old - 1, 5 - 2.0 ml every 2 to 3 hours until the cramps completely stop. 5-10 ml of 10% calcium chloride solution is administered intravenously at the same time or 1 tablespoon (dessert) spoon of 5% calcium chloride solution is prescribed 5-6 times daily. Outside of an attack, adults take 1 to 2 ml daily or every other day.

Highest doses for adults: single 5 ml, daily 15 ml.

Treatment with parathyroidine should be carried out under the control of the concentration of calcium in the blood, which should not exceed 12 mg% (in the International SI system of units: mmol / l - conversion factor 0.249).

With prolonged treatment with parathyroidin, its effectiveness decreases due to the development of resistance to it in patients. Therefore, after eliminating hypocalcemia, the patient should be prescribed vitamin D preparations and a diet high in calcium and low in phosphorus.

With an overdose of parathyroidin and hypercalcemia, general weakness and lethargy, vomiting and diarrhea are observed. In this case, the dose of the drug and the amount of calcium administered are reduced. If measures are not taken in a timely manner, more severe disorders (sharp adynamia, muscle atony, lethargy) can develop up to a coma.

Contraindicated in case of high blood calcium.

Release form: in ampoules of 1 ml.

Storage: List B. In a dark place at a temperature of + 1 to + 10 C.

Currently, the drug is considered obsolete and has no widespread use.