Description of the drug: Chlorpropamide (Chlorpropamidum)

Chlorpropamidum.

N- (p-Chlorobenzenesulfonyl) -N-propyl urea.

Synonyms: Bioglumin, Catanil, Chlorpropamide, Diabamide, Diabaryl, Diabet, Diabexan, Diabinese, Galiron, Mellinese, Prodiaben and others.

White crystalline powder odorless and tasteless. Almost nerastvorim in alcohol, benzene, acetone.

The structure, pharmacological properties and mechanism of action is close to butamid; Chemically differs from the latter in that, in the para position of the benzene nucleus, it contains the Cl atom instead of the CH3 group and instead of the butyl group (C4H9) with N 'contains a propyl group (C3H7).

In comparison with butamide, chlorpropamide is more active and has a lowering effect on sugar. Antibacterial effect does not cause.

Chlorpropamide is rapidly absorbed from the gastrointestinal tract; In the blood is detected within the first hour after administration; The peak concentration in the blood is reached after 2 to 4 hours. The drug is slowly excreted by the kidneys, mainly in unchanged form. After taking chlorpropamide, a more persistent concentration in the blood is created. The duration of the drug after a single dose is 24 - 36 hours, so it can be taken once a day.

Assign inside. With moderate diabetes with severe hyperglycemia and glucosuria, treatment starts with taking 0.5 g of the drug 1 time per day. Take in the morning before eating (usually at 7-8 in the morning). With mild forms of diabetes start with a dose of 0.25 g. In the absence of the effect of a dose of 0.25 g per day during the first week, the dose is raised to 0.5 g, and in some cases to 0.75 g (during the following week) . If, then, the effect is not detected, the further administration of chlorpropamide is impractical.

In some patients, there is a need in addition to the morning reception of chlorpropamide to appoint in the evening hours other drugs sulfonylurea.

In the case of normalization of glycemia and elimination of glucosuria from the intake of chlorpropamide, its dose is gradually reduced: by 0.125 g every 2 weeks, following the level of glucose in the blood and urine.

The maintenance dose, at which compensation for diabetic disorders is preserved, is usually 0.125-0.25 g per day.

When replacing insulin with chlorpropamide, approximately 0.25 g of chlorpropamide is prescribed instead of 20 units of insulin.

Chlorpropamide is also used in the treatment of diabetes insipidus. It is effective in a number of cases with refractory to pituitary medications (adiurecrino, etc.) and their intolerance.

Assign inside, starting with 0.125 grams per day, gradually increasing the dose by 0.125 g to 0.25-0.5 g (sometimes up to 0.75 g) per day.

The highest daily intake for adults inside 1 g.

The time of taking the drug depends on the tolerance. To avoid the development of hypoglycemia, it is advisable to take it once before or during breakfast; In case of poor tolerance (dyspepsia), the drug is administered immediately after meals. In the evening hours reception is not recommended.