Description of the drug: Hydrocortisone hemisuccinate (Hydrocortisoni hemisuccinas)

HYDROCORTIZONE HEMISUCCINATE (Hydrocortisoni hemisuccinas).

Synonyms: Arcocort, Corlan, Efcorlin, Hydrocortisone intraveineux, Hydrocortisone sodium succinate, Hydrocortisol soluble, Intracort, Solu-Cortef and others.

Produced in the form of sodium salt (sodium succinate) in lyophilized form (Hydrocortisoni hemisuccinas liophylisatum 0.025 and 0.1 pro injectionibus).

White or white with a slightly yellowish tinge porous mass or powder in ampoules of 5 or 10 ml, containing 0.025 or 0.1 g of the drug.

Applied with acute adrenal insufficiency, acute allergic reactions, asthmatic status, for the prevention and treatment of shock, with myocardial infarction complicated by cardiogenic shock, for the treatment of thyrotoxic crisis, with other indications for the use of corticosteroids.

Assign parenterally to create a high concentration in the blood.

Hydrocortisone hemisuccinate is administered intravenously (either jet or drip). If it is impossible to enter into a vein is administered intramuscularly.

The contents of the ampoule (25 or 100 mg of the drug) are dissolved immediately before use in 5 or 10 ml of water for injection, pre-heated to 35 - 37 C. When drip (30 - 70 drops per minute), this solution is diluted in 250-500 ml isotonic Solution of sodium chloride.

Single doses ranging from 25 - 50 to 200 - 300 mg (acute adrenal insufficiency, severe cases of shock), diurnal doses ranging from 25 - 150 to 1300 mg and more. In shock, the drug is first injected, then drip until the blood pressure stabilizes. A single dose of 50 - 150 mg, in severe cases it is increased to 300 mg. The daily dose is 1000 - 1300 mg and above. In acute adrenal insufficiency, a single dose of the drug is 100-200 mg. A patient with myocardial infarction complicated by dry pericarditis, the drug is usually administered at a dose of 50 mg per day for 7 to 10 days. With bronchial asthma, the daily dose is selected individually. In the case of severe allergic reactions, the drug is usually administered at a dose of 100 mg per day drip for 1 to 3 days. After the onset of therapeutic effect, daily doses gradually decrease.

Abrupt discontinuation of the drug is unacceptable.

Contraindications to use are the same as for other cortinosteroid drugs, as well as thrombophlebitis. In extreme conditions, contraindications can be regarded as relative.

Form release: in ampoules containing 0.025 and 0.1 g (25 and 100 mg) of the drug.

Storage: List B. In the dark place.