Description of the medicine: Hydrocortisone hemisuccinate (Hydrocortisoni hemisuccinas)
HYDROCORTISON HEMISUCCINATE (Hydrocortisoni hemisuccinas).
Synonyms: Arcocort, Corlan, Efcorlin, Hydrocortisone intraveineux, Hydrocortisone sodium succinate, Hydrocortistab soluble, Intracort, Solu-Cortef, etc.
Available in the form of sodium salt (sodium succinate) in lyophilized form (Hydrocortisoni hemisuccinas liophylisatum 0.025 et 0.1 pro injectionibus).
A porous mass, white or white with a slightly yellowish tint, or powder in ampoules of 5 or 10 ml, containing 0.025 or 0.1 g of the drug.
It is used for acute adrenal insufficiency, acute allergic reactions, asthmatic status, for the prevention and treatment of shock, for myocardial infarction complicated by cardiogenic shock, for the treatment of thyrotoxic crisis, and for other indications for the use of corticosteroid drugs.
Assign parenterally to create a high concentration in the blood.
Hydrocortisone hemisuccinate is administered intravenously (in a jet or drip). If it is impossible to enter into a vein, they are administered intramuscularly.
The contents of the ampoule (25 or 100 mg of the drug) are dissolved immediately before use in 5 or 10 ml of water for injection, preheated to 35 - 37 C. With a drip (30 - 70 drops per minute), this solution is diluted in 250 - 500 ml of isotonic sodium chloride solution.
Single doses range from 25-50 to 200-300 mg (acute adrenal insufficiency, severe cases of shock), daily allowances range from 25-150 to 1300 mg or more. In shock, the drug is administered first in a jet, then drip to stabilize blood pressure. A single dose of 50 to 150 mg, in severe cases, it is increased to 300 mg. The daily dose is 1000 - 1300 mg and above. In acute adrenal insufficiency, a single dose of the drug is 100-200 mg. Patients with myocardial infarction complicated by dry pericarditis, the drug is usually administered at 50 mg per day for 7 to 10 days. In bronchial asthma, the daily dose is selected individually. In case of severe allergic reactions, the drug is usually administered at a dose of 100 mg per day for 1 to 3 days. After the onset of the therapeutic effect, daily doses are gradually reduced.
Abrupt cessation of drug administration is unacceptable.
Contraindications to use are the same as for other cortinosteroids, as well as thrombophlebitis. In extreme conditions, contraindications can be considered relative.
Release form: in ampoules containing 0.025 and 0.1 g (25 and 100 mg) of the drug.
Storage: List B. In the dark place.