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Description of the medicine: Methylprednisolonum (Methylprednisolonum)

Methylprednisolone (Methylprednisolonum). 6- a - Methylprednisolone:

Synonyms: Medrol, Metipred, Urbazon, Bioprednon, Medeson, Medrate, Medrelon, Medrol, Medrone, Meristolone, Mesopren, Metastab, Methypred, Metipred, Metrisone, Moderin, Prednol, Promacortine, Suprametil, Urbason, Wyacort, etc.

An analogue of prednisolone. The activity is close to prednisone, but practically does not have mineralocorticoid (sodium retention) activity, which provides better tolerance. It is slowly absorbed by intramuscular administration and has a longer lasting effect than hydrocortisone and prednisone.

Indications for use are the same as for prednisone, however, methylprednisolone is in some cases more active, better tolerated.

Available in tablets of 0.004 g (4 mg) and 0.016 g (16 mg). In soluble form (in the form of sodium succinate) - in ampoules of 0.02 and 0.04 g (20 and 40 mg) for adults and 0.008 g (8 mg) for children (dry powder with an ampoule with a solvent - sterile water for injection), as well as in ampoules with a ready-made solution of 40 mg in 1 ml.

With bronchial asthma, it is prescribed orally, starting with 12 - 40 mg per day; maintenance dose of 4 to 12 mg per day. In chronic polyarthritis, it is prescribed starting with 6 - 20 mg per day. With rheumatism, they start with a dose of 0.8-1.5 mg / kg, then it is gradually reduced.

In acute cases, they are injected into the muscles or into a vein (drip or very slowly in a jet) for adults 20 to 40 mg, for children 8 to 16 mg, then they go on to take the drug inside.

If necessary, a solution of methylprednisolone is injected into the joint cavity (10 - 40 mg), into the abdominal and pleural cavities (up to 100 mg), under the conjunctiva (up to 20 mg).

There is evidence of the epidural administration of methylprednisolone (80 mg in 10 ml of isotonic sodium chloride solution) in the treatment of discogenic radiculitis.

Large doses of methylprednisolone (or prednisolone) were used in the treatment of especially severe forms of lupus nephritis.

Contraindications to the appointment of methylprednisolone and possible complications are the same as with other glucocorticosteroids.

Method of release: tablets of 0.004 g (4 mg) in a package of 30 pieces; in ampoules of 0.02; 0.04; 0.008 g (20; 40 and 8 mg) of sodium methylprednisolone succinate with the use of ampoules with a solvent; the drug << Solu-Medrol >> (Solu-Medrol), which is sodium succinate of methylprednisolone, is available in bottles.

The prolonged drug Depomedrol (Depot-Medrol) * is a 40% suspension of methylprednisolone acetate; Available in ampoules of 1 and 2 ml. Apply intramuscularly at 0.04 - 0.12 g (1-3 ml) 1 time in 1 to 4 weeks. Depending on the size of the joint, they are injected into the joint cavity from 0.004 to 0.08 g (4 to 80 mg) once every 1 to 5 weeks. In some cases, a single administration is sufficient.