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Medication Description: Methylprednisolone (Methylprednisolonum)

Methylprednisolone (Methylprednisolonum). 6- a - Methylprednisolone:

Synonyms: Medrol, metipred, Urbazon, Bioprednon, Medeson, Medrate, Medrelon , Medrol, Medrone, Meristolone, Mesopren, Metastab, Methypred, Metipred, Metrisone, Moderin, Prednol, Promacortine, Suprametil, Urbason, Wyacort et al.

Analogue prednisolone. By activity, it is close to prednisone, but practically does not possess mineralocorticoid (sodium retention) activity, which ensures better tolerability. It is slowly absorbed by intramuscular injection and has a longer lasting effect than hydrocortisone and prednisone.

Indications for use are the same as for prednisolone, but methylprednisolone is more active in some cases, better tolerated.

Available in tablets of 0.004 g (4 mg) and 0.016 g (16 mg). In soluble form (in the form of sodium succinate) - in ampoules of 0.02 and 0.04 g (20 and 40 mg) for adults and 0.008 g (8 mg) for children (dry powder attached with an ampoule with a solvent - sterile water for injection), as well as in ampoules with a prepared solution of 40 mg in 1 ml.

In case of bronchial asthma, it is prescribed orally, from 12 to 40 mg per day; maintenance dose of 4 - 12 mg per day. With chronic polyarthritis prescribed from 6 to 20 mg per day. When rheumatism begins with a dose of 0.8 - 1, 5 mg / kg, then it is gradually reduced.

In acute cases, an adult of 20 to 40 mg is injected into the muscles or into a vein (drip or very slowly with a stream) to adults, 8 to 16 mg to children, then transferred to the drug.

A solution of methylprednisolone, if necessary, is injected into the joint cavity (10-40 mg), into the abdominal and pleural cavities (up to 100 mg), under the conjunctiva (up to 20 mg).

There is evidence of epidural administration of methylprednisolone (80 mg in 10 ml of isotonic sodium chloride solution) in the treatment of discogenic sciatica.

Large doses of methylprednisolone (or prednisolone) were used in the treatment of very severe forms of lupus nephritis.

Contraindications to the appointment of methylprednisolone and possible complications are the same as when using other glucocorticosteroids.

Method of production: tablets of 0.004 g (4 mg) in a package of 30 pieces; in ampoules of 0.02; 0.04; 0.008 g (20; 40 and 8 mg) of sodium methylprednisolone succinate with the application of ampoules with a solvent; << Solu-Medrol >> (Solu-Medrol), which is methylprednisolone sodium succinate, is available in vials.

Depot-Medrol *, a prolonged preparation, is a 40% suspension of methylprednisolone acetate; Available in ampoules of 1 and 2 ml. Apply intramuscularly at 0.04 - 0.12 g (1-3 ml) 1 time in 1 to 4 weeks. Depending on the size of the joint, it is introduced into the cavity of the joint from 0.004 to 0.08 g (4–80 mg) once in 1 to 5 weeks. In some cases, a single injection is sufficient.