Drug Description: Deoxycorticosterone Acetate (Desoxycorticosteroni acetas)
Desoxycorticosterone Acetate (Desoxycorticosteroni acetas).
Pregnen-4-ol-21-dione-3, 20 acetate.
Synonyms: DOXA, Arcort, Desoxycorticosteronum aceticum, Cortarmur, Cortate, Cortenil, Cortexon, Cortinaq, Cortiron, Decorten, Decorton, Decosterone, Decostrate, Descorterone, Descortone, Desoxycortoni acetas, Desoxycortone acetate, aus, aus, aprc, aprc, aprc, Descortone, Descortone, Desoxycortoni acetas, Descortone acetum, Descortone acetum and etc.
White or with a faint creamy white odorless crystalline powder. Practically insoluble in water, soluble in alcohol and oils.
The drug is produced synthetically. Synthetic drug - deoxycorticosterone acetate (DOXA) - has the properties of the natural hormone of the adrenal cortex.
Deoxycortinoterone is a mineralocorticosteroid. It causes a delay in the body of sodium ions and increased excretion of potassium, which leads to an increase in tissue hydrophilicity; the volume of plasma increases, increases blood pressure. Deoxycorticosterone improves muscle tone and improves muscle performance.
The main indications for use of DOXS are Addison's disease and a temporary decrease in the function of the adrenal cortex (hypocorticism). The drug is also used in myasthenia, asthenia, adynamia, general muscular weakness, hypochloremia, and some other diseases.
Assign intramuscularly in oil solutions. In Addison's disease, depending on the severity of the disease, 0.005 g (5 mg) 3 times a week to 0.01 g (10 mg) daily is administered to reduce the severity of symptoms of the disease, and then 5 mg 1 to 2 times a week.
In Addison's disease, it is advisable to simultaneously administer glucocorticosteroids. Sodium chloride is also administered at the same time (4–10 g per day - in wafers or in the form of an aqueous solution of 10 g of sodium chloride with 5 g of sodium citrate and fruit juice).
In case of acute insufficiency of the adrenal cortex and in the addisonic crisis, 5-10 mg is administered 4 times a day.
With Addisonism, 5 mg of the drug is prescribed every other day (15 to 20 injections per course of treatment), for hypotonic conditions on the basis of reduced function of the adrenal cortex, 5 mg every other day or 2 days (a total of 12 to 15 injections).
Higher doses for adults intramuscularly: single 0.01 g (2 ml of 0.5% solution), daily 0.025 g (5 ml of 0.5% solution).
Deoxycorticosterone acetate can also be used for hypocorticism in the form of tablets under the tongue (behind the cheek): 1/2 to 1 tablet (2, 5 to 5, 0 mg) is administered once a day or every other day. The pill is kept until it is completely absorbed, without chewing or swallowing.
Drug treatment should be carried out under the close supervision of a physician. With an overdose, edema can develop (due to sodium and water retention), an increase in blood pressure.
Contraindicated in hypertension, heart failure with edema, atherosclerosis, angina, nephritis, nephrosis, cirrhosis of the liver.
Method of production: 0.5% solution in oil in 1 ml ampoules (0.005 g in 1 ampoule); tablets of 0.005 g (5 mg) for sublingual use.
Storage: List B. In the dark spot.
Rp .: Sol. Desoxycorticosteroni aceta tis oleosae 0.5%
DtdN 6 in ampull.
S. 1 ml every other day intramuscularly
R p.: Tab. Desoxycorticosteroni ace tatis 0,005 N. 50