Attention! The information is for reference purposes!
Before taking you should consult with a doctor!
SITE GUIDE ONLY. Not a pharmacy! We do not sell drugs! Nothing!

Description medications: deoxycorticosterone acetate (Desoxycorticosteroni acetas)

Deoxycorticosterone ACETATE (Desoxycorticosteroni acetas).

4-pregnene-21-ol-3-dione, 20 acetate.

Synonyms: Doxa, Arcort, Desoxycorticosteronum aceticum, Cortarmur, Cortate, Cortenil, Cortexon, Cortinaq, Cortiron, Decorten, Decorton, Decosterone, Decostrate, Descorterone, Descortone, Desoxycortoni acetas, Desoxycortone acetate, DOCA, Dohycamon, Dorcostrin, Percorten, Steraq, Syncortyl and etc.

White or cream shade with a weak, crystalline powder. Practically insoluble in water, soluble in alcohol and oils.

The drug is prepared synthetically. Synthetic drugs - deoxycorticosterone acetate (Dox) - has the properties of the natural hormone of the adrenal cortex.

Dezoksikortinosteron is mineralokortikosteroidom. It inhibits the sodium ions in the body, and increased potassium excretion, which results in increased hydrophilicity of tissue; plasma volume will be increased, increased blood pressure. Deoxycorticosterone increases the tone and improves muscle performance.

The main indications for the use of Doxey are Addison's disease and a temporary decrease in the function of the adrenal cortex (gipokortitsizm). The drug is also used in myasthenia gravis, fatigue, weakness, general muscle weakness, chloropenia and some other diseases.

Assign intramuscularly in oily solutions. Addison's disease are administered depending on the severity of the disease, from 0.005 g (5 mg) 3 times a week to 0.01 g (10 mg) daily to reduce the severity of symptoms, and then 5 mg of 1 - 2 times a week.

In Addison's disease at the same time it is advisable to introduce steroids. Assign also simultaneously sodium chloride (4 - 10 g daily - or wafer in an aqueous solution of 10 g of sodium chloride with 5 g of sodium citrate and fruit juice).

In acute adrenal insufficiency and Stroke addisonicheskom administered 5 - 10 mg 4 times a day.

When addisonizme appoint 5 mg a day (15 - 20 injections per course of treatment), with hypotonic states on the basis of the reduced function of the adrenal cortex - 5 mg every other day or every 2 days (12 - 15 injections).

Higher doses intramuscularly to adults: single 0.01 g (2 ml of 0.5% solution), 0.025 g daily (5 ml of 0.5% solution).

Deoxycorticosterone acetate can also be used when gipokortitsizm in the form of tablets under the tongue (on the cheek): appointed by 1/2 - 1 tablet (2, 5 - 5, 0 mg) 1 every day or every other day. The tablet is held until resorption not liquid and not swallowing.

Drug treatment should be under close medical supervision. In case of overdose may develop swelling (due to sodium and water retention), increased blood pressure.

Contraindicated in hypertension, heart failure, edema, atherosclerosis, angina, nephritis, nephrosis, cirrhosis of the liver.

production: 0.5% solution in oil in 1 ml ampoules (0.005 g in 1 ampoule); 0,005 g of tablets (5 mg) for sublingual use.

Storage: List B. In the dark spot.

Rp .: Sol. Desoxycorticosteroni aceta tis oleosae 0,5%

DtdN 6 in ampull.

S. At 1 ml intramuscularly every other day

Rp .: Tab. Desoxycorticosteroni ace tatis 0,005 N. 50

DS