Description of the medicine: Desoxycorticosterone acetate (Desoxycorticosteroni acetas)
DESOXICORTICOSTERONE ACETATE (Desoxycorticosteroni acetas).
Pregnen-4-ol-21-dione-3, 20 acetate.
Synonyms: DOXA, Arcort, Desoxycorticosteronum aceticum, Cortarmur, Cortate, Cortenil, Cortexon, Cortinaq, Cortiron, Decorten, Decorton, Decosterone, Decostrate, Descorterone, Descortone, Desoxycortoni acetas, Desoxycortone acetate, Doca Docrac, Doca Doca, Doca Doca, Doca Doca, Doca Doca, Doca Doca, Doca, Doca, Doca, Doca, Doca, Doca, Doca, Doca, Doc, Doca and etc.
Flavourless crystalline powder, white or with a slight cream tint. Practically insoluble in water, soluble in alcohol and oils.
The drug is obtained synthetically. A synthetic drug - deoxycorticosterone acetate (DOXA) - has the properties of the natural hormone of the adrenal cortex.
Deoxycortinosterone is a mineralocorticosteroid. It causes a delay in the body of sodium ions and increased excretion of potassium, which leads to increased hydrophilicity of tissues; the plasma volume increases, blood pressure rises. Deoxycorticosterone increases tone and improves muscle performance.
The main indications for the use of DOX are Addison's disease and a temporary decrease in the function of the adrenal cortex (hypocorticism). The drug is also used for myasthenia gravis, asthenia, adynamia, general muscle weakness, hypochloremia and some other diseases.
Assign intramuscularly in oil solutions. In Addison’s disease, they are administered, depending on the severity of the disease, from 0.005 g (5 mg) 3 times a week to 0.01 g (10 mg) daily to reduce the severity of the symptoms of the disease, and then 5 mg 1 to 2 times a week.
In Addison's disease, it is advisable to simultaneously administer glucocorticosteroids. Sodium chloride is also prescribed at the same time (4 - 10 g per day - in cachets or in the form of an aqueous solution of 10 g of sodium chloride with 5 g of sodium citrate and fruit juice).
In case of acute insufficiency of the adrenal cortex and with addison crisis, 5-10 mg is administered 4 times a day.
With addisonism, 5 mg of the drug is prescribed every other day (15 - 20 injections per treatment course), with hypotonic conditions due to decreased function of the adrenal cortex - 5 mg every other day or 2 days later (a total of 12 to 15 injections).
Higher doses for adults intramuscularly: a single dose of 0.01 g (2 ml of a 0.5% solution), daily 0.025 g (5 ml of a 0.5% solution).
Deoxycorticosterone acetate can also be used for hypocorticism in the form of tablets under the tongue (per cheek): 1/2 - 1 tablet (2, 5 - 5, 0 mg) is prescribed once a day or every other day. The tablet is held until completely resorbed, without chewing or swallowing.
Treatment with the drug should be carried out under close medical supervision. In case of an overdose, edema can develop (due to a delay in sodium and water), an increase in blood pressure.
Contraindicated in hypertension, heart failure with edema, atherosclerosis, angina pectoris, nephritis, nephrosis, cirrhosis.
Method of release: 0.5% solution in oil in ampoules of 1 ml (0.005 g in 1 ampoule); tablets of 0.005 g (5 mg) for sublingual administration.
Storage: List B. In the dark place.
Rp .: Sol. Desoxycorticosteroni aceta tis oleosae 0.5%
DtdN 6 in ampull.
S. 1 ml every other day intramuscularly
Rp.: Tab. Desoxycorticosteroni ace tatis 0.005 N. 50