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Description of the medicine: Estradiol dipropionate (Oestradioli dipropionas)

Estradiol dipropionate (Oestradioli dipropionas).

Estratriene-1, 3, 5 (10) -diol-3, 17 b dipropionate.

Synonyms: Estradiol propionate, Dimenformon dipropionate, Diogyn DP, Diovocyclin, Estradiol diproplonate, Estradioli dlpropionas, Oestradiolum dipropionicum, Ovocyclin dipropionate, Progynon DP, Synformon.

White crystalline powder. Practically insoluble in water, hardly soluble in alcohol and vegetable oils.

Estradiol is formed in the body of a woman along with estrone; has a greater estrogenic activity. The activity of 1 mg of estradiol benzoate corresponds to 10,000 units.

In the form of esters (benzoate or dipropianate), estradiol is slightly destroyed in the tissues of the body. Estradiol esters are slowly absorbed, excreted and have a lasting effect on the body; they can therefore be administered relatively rarely, with large intervals between injections.

Estradiol dipropionate has a strong, delayed and prolonged estrogenic effect.

In general, indications for the use of the drug coincide with those for estrone.

In addition, estradiol dipropionate is used as a hemostatic agent in men with acute radiation damage. The drug has the ability to increase the number of leukocytes (neutrophils) and accelerate the restoration of their number during myelodepression associated with radiation damage.

Estradiol dipropionate is administered intramuscularly. With insufficient ovarian function, a 0.1% solution in oil of 1 ml is used once every 3 to 5 days.

The schedule and duration of treatment depends on the nature of the disease, therapeutic efficacy, etc. (see Estron).

Contraindications are the same as for estrone.

As a hemostatic agent of estradiol, dipropionate is used to reduce the number of leukocytes below 2000 in 1 μl of blood (usually from 10 to 20 days after irradiation with severe lesions and from 15 to 18 days with lighter lesions). Enter 1 ml of a 0.1% solution after 1 to 2 days. The course is 10 injections (if necessary, up to 15 injections).

Release form: 0.1% solution (1 mg) in oil in ampoules of 1 ml.

Storage: List B. In a cool, dark place.

Rp .: Sol. Oestradioli dipropionatis oleosae 0.1% 1 ml

DtdN 6 in ampull.

S. 1 ml per muscle

Menopause (Climakterin) *. The combined drug. Contains 25 U of estradiol benzoate in one tablet (dragee), 30 mg of dry ovarian powder, 0.025 g of theobromine and caffeine, 0.0002 g of nitroglycerin, 0.006 g of phenolphthalein, 0.004 g of calcium phosphate.

Applied with angioneurotic phenomena that occur in the menopause.

Assign 1 to 2 tablets 2 to 3 times a day.

Release form: dragee in packing of 50 pieces.

Storage: List B.