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Medication description: Estradiol dipropionate (Oestradioli dipropionas)

ESTRADIOL DIPROPIONAT (Oestradioli dipropionas).

Estratirien-1, 3, 5 (10) -diol-3, 17 b dipropionate.

Synonyms: estradiol propionate, Dimenformon dipropionate, Diogyn DP, Diovocyclin, Estradiol diproplonate, Estradioli dlpropionas, Oestradiolum dipropionicum, Ovocyclin dipropionate, Progynon DP, Synformon.

White crystalline powder. Practically insoluble in water, difficult to dissolve in alcohol and vegetable oils.

Estradiol is formed in the body of a woman along with estron; possesses greater estrogenic activity. The activity of 1 mg of estradiol benzoate corresponds to 10 000 IU.

In the form of esters (benzoate or dipropianate), estradiol is little destroyed in the tissues of the body. Esters of estradiol are slowly absorbed, excreted and have a lasting effect on the body; they can therefore be administered relatively rarely, with long intervals between injections.

Estradiol dipropionate has a strong, delayed and prolonged estrogenic effect.

Basically, the indications for use of the drug coincide with those for estrone.

In addition, estradiol dipropionate is used as a hemostimulating agent in men with acute radiation damage. The drug has the ability to increase the number of leukocytes (neutrophils) and accelerate the recovery of their number during myelodepression associated with radiation damage.

Estradiol dipropionate is administered intramuscularly. With insufficient ovarian function, apply a 0.1% solution in oil, 1 ml 1 time in 3 to 5 days.

The scheme and duration of treatment depends on the nature of the disease, therapeutic efficacy, etc. (see Estron).

Contraindications are the same as for estrone.

As a hemostimulating agent, estradiol dipropionate is used in reducing the number of leukocytes below 2000 in 1 μl of blood (usually from 10–20 days after irradiation in severe lesions and from 15–18 days in lighter lesions). Enter 1 ml of 0.1% solution in 1 to 2 days. The course is 10 injections (if necessary - up to 15 injections).

Product form: 0.1% solution (1 mg) in oil in 1 ml ampoules.

Storage: List B. In a cool, dark place.

Rp .: Sol. Oestradioli dipropionatis oleosae 0.1% 1 ml

DtdN 6 in ampull.

S. 1 ml in the muscles

Climacterin (Climakterin) *. Combined drug. Contains in one tablet (dragee) of estradiol benzoate 25 U, dry ovarian powder 30 mg, theobromine and caffeine 0.025 g, nitroglycerin 0.0002 g, phenolphthalein 0.006 g, calcium phosphate 0.004 g

Apply with angioedema occurring in menopause.

Assign 1 to 2 tablets 2 to 3 times a day.

Form release: pills in a package of 50 pieces.

Storage: List B.