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Description drugs: Ethinyl estradiol (Aethinyloestradiolum)

Ethinyl estradiol (Aethinyloestradiolum). -Etinilestratrien 17 a-1, 3, 5 (10) - diol 3, 17 b.

Synonyms: mikrofollin, Athinylostradiol, Diogyn E, Diolyn, Dyloform, Estigyn, Estinyl, Eston-E, Estrolan E, Ethidol, Ethin-Oestryl, Ethinoral, Ethynilestradiol, Ethynilestradiolum, Eticyclin, Eticyclol, Etivex, Feminone, Fodinyl, Follikoral, Gynoral, Kolpolyn, Linoral, Lynestoral, Lynoral, Metroval, Microfollin, Oestralyn, Oestroperos, Oradiol, Orestralyn, Ostral, Perovex, Primogyn C, Primogyn M, Progynon S, Progynon M et al.

White or creamy white crystalline powder. Practically insoluble in water, soluble in alcohol and vegetable oils.

According to the structure and operation of ethinyl estradiol is close to. Chemically different switching ethynyl radical in position C (17) which leads to significant enhancement of activity.

Ethinyl estradiol is one of the most modern active estrogenic drugs. Furthermore, it is effective when taken orally.

Indications for use of ethinyl estradiol coincide with those for estrone.

Assign inside; the dose and duration of use should be individualized depending on the nature of the disease and the effectiveness of treatment.

In gipogenitalizme (primary amenorrhea) is usually administered at 0.05 - 0.1 mg (0.00005 - 0.0001 g), 2 times a day for 3 - 4 weeks, after which the drugs are used progestin (progesterone, etc.) In for 6 - 8 days. The course of treatment was repeated 5 - 6 times.

When hypofunction ovarian and secondary amenorrhea prescribed drug in the same dose of 1 - 2 times a day for 2 - 3 weeks, and then for 6 - 8 days - progestin drugs (progesterone 5 - 10 mg per day, intramuscularly or pregnin 10 - 30 mg sublingually 3 times a day).

When menopausal disorders in women younger than 45 years should take 0.01 0.02 - 0.05 g of ethinyl estradiol daily for several days, then progesterone or pregnin for 6 - 8 days. The course of treatment is repeated 2 - 3 times.

To eliminate drug neurovascular disorders at estrogen failure appoint 0.01 - 0.02 mg per day for 10 - 15 days; treatment can be repeated after a break of a few days.

In women with dysmenorrhea symptoms of uterine hypoplasia ethinylestradiol are administered inside immediately after menstruation to 0.01 mg a day for 2 - 3 weeks on alternate days or daily.

Ethinylestradiol may be applied, like other estrogen drugs (usually in combination with radiation therapy) for the treatment of prostate cancer and breast cancer (in women older than 60 years) cancer. In these cases, the drug administered in relatively large doses: 3 mg per day; prolonged treatment.

Ethinyl estradiol is generally well tolerated; at higher doses may be nausea, vomiting, dizziness.

Indications are the same as for estrone.

Product: pills to 0.01 and 0.05 mg (0.00001 and 0.00005 g).

Storage: List B. In the dark spot.

Ethinyl estradiol has, under certain conditions the contraceptive effect (see. Oral contraceptives), and is part of a series of oral contraceptive agents (see. Bisekurin, Rigevidon, Non-ovlon et al.).