Description of the medicine: Ethinyl estradiol (Aethinyloestradiolum)
ETHINYLESTRADIOL (Aethinyloestradiolum). 17 a-Ethinyl estratriene-1, 3, 5 (10) - diol-3, 17 b.
Synonyms: Microfollin, Athinylostradiol, Diogyn E, Diolyn, Dyloform, Estigyn, Estinyl, Eston-E, Estrolan E, Ethidol, Ethin-Oestryl, Ethinoral, Ethynilestradiol, Ethynilestradiolum, Eticyclin, Eticyclol, Etivex, Feminal, Feminal, Feminal, Feminal, Feminal, Feminal, Feminal Kolpolyn, Linoral, Lynestoral, Lynoral, Metroval, Microfollin, Oestralyn, Oestroperos, Oradiol, Orestralyn, Ostral, Perovex, Primogyn C, Primogyn M, Progynon S, Progynon M, etc.
White or creamy white fine crystalline powder. Practically insoluble in water, soluble in alcohol and vegetable oils.
The structure and action of ethinyl estradiol is close to estradiol. Chemically different by the inclusion of an ethynyl radical in position C (17), which leads to a significant increase in activity.
Ethinyl estradiol is one of the most active modern estrogen preparations. In addition, it is effective when taken orally.
Indications for the use of ethinyl estradiol coincide with those for estrone.
Assign inside; doses of the drug and the duration of use should be individualized depending on the nature of the disease and the effectiveness of the treatment.
In case of hypogenitalism (primary amenorrhea), 0.05 - 0.1 mg (0.00005 - 0.0001 g) is usually prescribed 2 times a day for 3 to 4 weeks, after which gestagen drugs (progesterone, etc.) are used within 6 to 8 days. The course of treatment is repeated 5-6 times.
With ovarian hypofunction and secondary amenorrhea, the drug is prescribed in the same dose 1 to 2 times a day for 2 to 3 weeks, then for 6 to 8 days gestagen drugs (progesterone 5 to 10 mg per day intramuscularly or pregnin 10 to 10 30 mg under the tongue 3 times a day).
For menopausal disorders, women under the age of 45 years should take 0.01-0.02-0.05 g of ethinyl estradiol daily for several days in a row, then progesterone or pregnin for 6-8 days. The course of treatment is repeated 2 to 3 times.
To eliminate neurovascular disorders in estrogen deficiency, the drug is prescribed at 0.01 - 0.02 mg per day for 10 - 15 days; the course of treatment can be repeated after a break of several days.
With dysmenorrhea in women with signs of uterine underdevelopment, ethinyl estradiol is administered orally immediately after the end of menstruation at 0.01 mg per day for 2 to 3 weeks daily or every other day.
Ethinyl estradiol can be used, like other estrogen preparations (usually in combination with radiation therapy), in the treatment of prostate cancer and breast cancer (in women over 60 years old). In these cases, the drug is prescribed in relatively large doses: up to 3 mg per day; long-term treatment.
Ethinyl estradiol is usually well tolerated; at high doses, nausea, vomiting, dizziness are possible.
Contraindications are the same as for estrone.
Release form: tablets of 0.01 and 0.05 mg (0.00001 and 0.00005 g).
Storage: List B. In the dark place.
Ethinyl estradiol has a contraceptive effect under certain conditions (see Oral contraceptives) and is an integral part of a number of oral contraceptives (see Bisekurin, Rigevidon, Non-ovlon, etc.).