Medication Description: Ethinyl Estradiol (Aethinyloestradiolum)
ETHINYLESTRADIOL (Aethinyloestradiolum). 17 a-Ethinyl estratin-1, 3, 5 (10) - diol-3, 17 b.
Synonyms: Microfollin, Athinylostradiol, Diogyn E, Diolyn, Dyloform, Estigyn, Estinyl, Eston-E, Estrolan E, Ethidol, Ethin-Oestryl, Ethinoral, Ethynilestradiol, Ethynilestradiolum, Eticyclin, Eticyclol, in-general, in-kind, in-kind, Eticyclin, Eticyclol, in-the-words, in-kind, Eticyclin, Eticyclol, in-law, in-kind, Eticyclin, Eticyclol, in-law, in-law, in Ethicile, Ethynilestradiol, Ethynilestradiolum; Kolpolyn, Linoral, Lynestoral, Lynoral, Metroval, Microfollin, Oestralyn, Oestroperos, Oradiol, Orestralyn, Ostral, Perovex, Primogyn C, Primogyn M, Progynon S, Progynon M, etc.
White or creamy white crystalline powder. Practically insoluble in water, soluble in alcohol and vegetable oils.
Ethinyl estradiol is similar to estradiol in structure and action. Chemically distinguished by the inclusion of the ethinyl radical in position C (17), which leads to a significant increase in activity.
Ethinyl estradiol is one of the most active modern estrogen drugs. In addition, it is effective when taken orally.
Indications for use of ethinyl estradiol coincide with those for estrone.
Assign inside; doses of the drug and the duration of use should be individualized depending on the nature of the disease and the effectiveness of treatment.
In hypogenitalism (primary amenorrhea), it is usually prescribed at 0.05–0.1 mg (0.00005–0,0001 g) 2 times a day for 3–4 weeks, after which gestagenic preparations (progesterone, etc.) are used in for 6 to 8 days. The course of treatment is repeated 5-6 times.
For ovarian hypofunction and secondary amenorrhea, the drug is prescribed in the same dose 1 to 2 times a day for 2 to 3 weeks, then for 6 to 8 days - gestagen preparations (progesterone 5 to 10 mg per day intramuscularly or pregnin 10 to 30 mg under the tongue 3 times a day).
For menopausal disorders, women under the age of 45 should take 0.01– 0.02– 0.05 g of ethinyl estradiol daily for several days in a row, then progesterone or pregnin for 6–8 days. The course of treatment is repeated 2 - 3 times.
To eliminate neurovascular disorders with estrogen deficiency, the drug is prescribed in 0.01-0.02 mg per day for 10-15 days; The treatment can be repeated after a break of several days.
In dysmenorrhea in women with signs of uterine underdevelopment, ethinyl estradiol is administered orally immediately after the end of menstruation, at 0.01 mg per day for 2 to 3 weeks daily or every other day.
Ethinyl estradiol can be used, like other estrogen drugs (usually in combination with radiation therapy), in the treatment of prostate cancer and breast cancer (in women older than 60 years). In these cases, the drug is prescribed in relatively large doses: up to 3 mg per day; long-term treatment.
Ethinyl estradiol is usually well tolerated; at high doses, nausea, vomiting, dizziness.
Contraindications are the same as for estrone.
Product form: tablets of 0.01 and 0.05 mg (0.00001 and 0.00005 g).
Storage: List B. In the dark spot.
Ethinyl estradiol has a contraceptive effect under certain conditions (see Oral contraceptives) and is an integral part of a number of oral contraceptive preparations (see Bicecurin, Ripevidon, Non-ovlon, etc.).