Description of the medicine: Sinestrol (Synoestrolum)
SINESTROL (Synoestrolum). Meso-3, 4-Di- (para-hydroxyphenyl) -hexane.
Synonyms: Cycloestrol, Dihydrostilbostrul, Estrene, Estronal, Folliplex, Hexanostrol, Hexestrol, Hexestrolum, Hexoestrolum, Hormonestrol, Novostrol, Syntex, Synthovo, etc.
Flavourless white or white with a slightly yellowish tint. Almost insoluble in water, easily soluble in alcohol, difficult in peach oil.
Sinestrol is a synthetic compound - a derivative of stilbene.
In chemical structure it differs from steroid estrogen hormones, but in biological and therapeutic properties it is close to them. Diethylstilbestrol, dimestrol and other synthetic estrogen preparations also belong to the group of stilbene derivatives.
In the first years after receiving these synthetic estrogens were widely used in medical practice. In the future, in connection with obtaining more effective and better tolerated drugs (ethinylestradiol, etc.), the use of synestrol and diethylstilbestrol became more limited.
Sinestrol is estrogen equivalent in estrogenic activity: 1 mg of sinestrol corresponds to 10,000 units.
Indications for use in women are basically the same as indications for the use of estrone. Sometimes prescribed for hypertrophy and prostate cancer in men.
Intramuscularly, under the skin and inside; intramuscularly and under the skin in oily solutions, inside - in tablets. When administered orally, synestrol is rapidly absorbed; not destroyed in the gastrointestinal tract.
In case of hypogenitalism, congenital amenorrhea and a sharply underdeveloped uterus, they use 0.001-0.002 g (1 - 2 mg) intramuscularly or 0.002 g (2 mg) by mouth daily for 4-6 weeks or more. If there is an effect, then progesterone (5 mg daily intramuscularly) or pregnin (10 mg 3 times daily inside) is prescribed for 6 to 8 days. If necessary, hormone therapy courses are repeated.
With secondary amenorrhea, 1 to 2 mg of synestrol is prescribed per day for 15 to 20 days, then for 6 to 8 days, progesterone or pregnin in the specified dose.
With hypo-oligomenorrhea, the drug is prescribed 1 mg intramuscularly or orally every day or every other day during the first half of the menstrual period; with infertility due to underdevelopment of the uterus - 1 mg intramuscularly or 1 to 2 mg orally in the first 7 to 8 days after menstruation; for menopausal disorders, it is prescribed orally at 0.0005 - 0.001 g (0.5 - 1 mg). The duration of treatment is individualized (see Estron).
To reduce lactation in women in the postpartum period, 0.001 g 2 times a day is prescribed orally or 1 ml of a 0.1% solution once a day intramuscularly for 2 days; for complete suppression of lactation - 0.002-0.003 g per day or 1 ml of a 0.1% solution 2 times a day for 5 to 7 days.
For breast cancer in women over 60 years of age, a 2% solution of synestrol is used. It is administered daily, starting from 1 ml per day, then the daily dose is gradually increased by 5 ml. By careful observation, the optimal dose is established, which is administered over a long time.