Medication Description: Synestrol (Synoestrolum)
SINESTROL (Synoestrolum). meso-3, 4-di- (para-hydroxyphenyl) -hexane.
Synonyms: Cycloestrol, Dihydrostilbostrul, Estrene, Estronal, Folliplex, Hexanostrol, Hexestrol, Hexestrolum, Hexoestrolum, Hormonestrol, Novostrol, Syntex, Synthovo, etc.
White or white powder with a slightly yellowish odorless odor. Practically insoluble in water, easily soluble in alcohol, it is difficult - in peach oil.
Synestrol is a synthetic compound derived from stilbene.
On a chemical structure differs from steroid estrogen hormones, but on biological and medical properties is close to them. The group of stilbene derivatives also includes diethylstilbestrol, diamethrol and other synthetic estrogen drugs.
In the first years after receiving these synthetic estrogens were widely used in medical practice. Further, in connection with obtaining more effective and better-tolerated drugs (ethinyl estradiol, etc.), the use of synestrol and diethylstilbestrol became more limited.
Synestrol on estrogenic activity is equivalent to estrone: 1 mg of synestrol corresponds to 10,000 IU.
Indications for use in women are basically the same as the indications for the use of estrone. Sometimes prescribed for hypertrophy and prostate cancer in men.
Injected intramuscularly, under the skin and inside; intramuscularly and under the skin in oily solutions, inside - in tablets. When administered orally, synestrol is rapidly absorbed; not destroyed in the gastrointestinal tract.
In case of hypogenitalism, congenital amenorrhea and a sharply underdeveloped uterus, 0.001-0.002 g (1–2 mg) intramuscularly or 0.002 g (2 mg) orally daily for 4–6 weeks or more are used. If there is an effect, then progesterone is prescribed (5 mg per day intramuscularly) or pregnin (10 mg 3 times a day orally) for 6 to 8 days. If necessary, hormone therapy courses are repeated.
For secondary amenorrhea, 1 to 2 mg of synestrol is prescribed per day for 15 to 20 days, then for 6 to 8 days, progesterone or pregnine at the indicated dose.
In case of hypooligorrhea, the drug is prescribed in 1 mg intramuscularly or orally every day or every other day during the first half of the intermenstrual period; for infertility on the basis of uterine underdevelopment, 1 mg intramuscularly or 1 to 2 mg orally for the first 7 to 8 days after menstruation; for menopausal disorders, a dose of 0.0005 to 0.001 g (0.5 to 1 mg) is prescribed. The duration of treatment is individualized (see Estron).
To reduce lactation in women in the postpartum period, appoint 0.001 g 2 times a day inside or 1 ml of a 0.1% solution 1 time a day intramuscularly for 2 days; for complete suppression of lactation - 0.002-0.003 g per day or 1 ml of 0.1% solution 2 times a day for 5-7 days.
In breast cancer in women older than 60 years, use a 2% solution of synestrol. Enter daily, starting with 1 ml per day, then gradually increase the daily dose of 5 ml. By careful observation, the optimal dose is established, which is administered over a long period of time.