Medication Description: Diethylstilbestrol (Disethylstilboestrolum)
Disethylstilboestrolum (Disethylstilboestrolum). trans-3, 4-di- (para-hydroxyphenyl) -hexene-3.
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White crystalline powder. Soluble in alcohol, ether, fatty oils; very little soluble in water.
Synthetic compound that has an estrogenic effect. The degree of activity exceeds estrone and synestrol. 1 mg contains 20 000 IU.
Earlier, diethylstilbestrol was relatively widely used as an estrogen agent in gynecological practice, as well as in hypertrophy and prostate cancer. Currently, due to side effects, it has limited use.
Diethylstilbestrol is sometimes used in the treatment of breast cancer in women. As well as synestrol, it is prescribed only to women over 60 years old. Dose of diethylstilbestrol due to its greater activity should be 2 to 3 times less than the dose of synestrol.
Higher single and daily doses of intramuscularly for malignant neoplasms 0.06 g
Contraindications to the use of the same as for estrone. You should not prescribe the drug for diseases of the liver and kidneys.
Treatment must be carried out under close medical supervision.
Product form: 3% solution in oil in 1 ml ampoules (30 mg in 1 ampoule); used only in the treatment of patients with malignant neoplasms.
Storage: List B. In the dark spot.