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Description medications: Diethylstilbestrol (Disethylstilboestrolum)
Diethylstilbestrol (Disethylstilboestrolum). trans-3, 4-di (p - hydroxyphenyl) - hexene-3.
Synonyms: Agostilben, Diethylstilbestrol, Diethylstilbestrolum, Estrobeme , Estromenin, Neoestranol, Newoestranol, Oestramon, Oestrogenin, Oestromenin, Oestrosyntal, Oroestron, Pabestrol, Sibarol, Stilbestrol, Stilbetin, Stilboestroform, Stilboestron, Stilbofolin, Stilboral, Synestrin, Synthoestrin, Syntofollin and others.
The white crystalline powder. Soluble in alcohol, ether, fatty oils; very slightly soluble in water.
Synthetic compound having estrogenic activity. According to the degree of activity exceeds estrone and sinestrol. The 1 mg contains 20 000 IU.
Earlier diethylstilbestrol relatively widely used as an estrogenic agent in gynecological practice, as well as hypertrophy and prostate cancer. Currently, due to the side effects it has limited application.
Sometimes the use of diethylstilbestrol in treating cancer of breast in women. As sinestrol, it is prescribed only to women older than 60 years. Diethylstilbestrol dose due to its greater activity should be 2 - 3 times lower than the dose sinestrola.
Higher-time and daily e of PS intramuscularly with malignant tumors 0.06 g
Contraindications are the same as for estrone. It should not be prescribed the drug for liver and kidney.
Treatment should be under close medical supervision.
Product: 3% solution in oil in 1 ml vials (30 mg in 1 ampoule); used only in the treatment of patients with malignant neoplasms.
Storage: List B. In the dark spot.
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