Medication Description: Progesterone (Progesteronum)
Synonyms: Agolutin, Akrolutin, Gestone, Glanducorpin, Gynlutin, Lipolutin, Lucorten, Luteine, Luteogan, Luteopur, Luteostab, Luteosterone, Lutocyclin, Lutoform, Lutogyl, Lutren, Lutromon, Lutromon, Lahren, Lutroman others
White crystalline powder. Practically insoluble in water, soluble in alcohol, difficult to dissolve in vegetable oils.
It is a hormone of the yellow body. For medical use get synthetically. A number of synthetic drugs that are similar in structure to progesterone (see Pregnin, Norethisterone, and others) and are active progestins, i.e. substances with progesterophobia-like activity, have also been obtained.
Endogenous progesterone causes the transition of the mucous membrane of the uterus from the proliferation phase caused by follicular hormone to the secretory phase, and after fertilization promotes its transition to the state necessary for the development of a fertilized egg. It also reduces the excitability and contractility of the musculature of the uterus and fallopian tubes, stimulates the development of the terminal elements of the mammary gland.
Synthetic progesterone and its analogues have a similar effect when they are used as medicines.
Progesterone is prescribed for amenorrhea, anovulatory uterine bleeding, infertility, premature pregnancy, algomenorrhea on the basis of hypogenitalism. Enter in the form of oil solutions intramuscularly or subcutaneously.
For bleeding associated with ovarian dysfunction, appoint 0.005-0.015 g (5-15 mg) daily for 6-8 days. If the curettage of the mucous membrane of the uterine cavity is pre-made, injections begin after 18 to 20 days. If it is not possible to make curettage, progesterone is also administered during the bleeding. When using progesterone during bleeding, it may temporarily (for 3 - 5 days) increase; It is recommended that patients with severely anemized patients receive a blood transfusion (200-250 ml). At the stopped bleeding should not interrupt treatment before 6 days. If the bleeding has not stopped after 6 to 8 days of treatment, the further administration of progesterone is not advisable.
In hypogenitalism and amenorrhea, treatment begins with the administration of estrogenic drugs in order to cause sufficient proliferation of the endometrium. Directly after the end of the use of estrogenic drugs, progesterone is prescribed in the form of injections of 5 mg daily or 10 mg every other day for 6-8 days (see Estron).
With algodysmenorrhea (dysmenorrhea), progesterone often reduces or eliminates pain. Treatment begins 6 to 8 days before menstruation. The drug is administered daily in 5 or 10 mg for 6 to 8 days. The course of treatment can be repeated several times. Progesterone treatment of algomenorrhea associated with uterine underdevelopment can be combined with the appointment of estrogen drugs. Estrogens are administered at the rate of 10 000 IU every other day for 2-3 weeks; then progesterone is administered for 6 days.