Description of the medicine: Progesterone (Progesteronum)
Synonyms: Agolutin, Akrolutin, Gestone, Glanducorpin, Gynlutin, Lipolutin, Lucorten, Luteine, Luteogan, Luteopur, Luteostab, Luteosterone, Lutocyclin, Lutoform, Lutogyl, Lutren, Proutelon, Lutromon, Lutrone, Progutgen, Progelest, Progelin other
White crystalline powder. It is practically insoluble in water, soluble in alcohol, hardly soluble in vegetable oils.
It is a hormone of the corpus luteum. For medical use, get synthetically. A number of synthetic preparations have also been obtained that are close in structure to progesterone (see Pregnin, Norethisterone, etc.) and are active progestins, i.e., substances that have progesterone-like activity.
Endogenous progesterone causes the transition of the uterine mucosa from the proliferation phase caused by the follicular hormone to the secretory phase, and after fertilization it contributes to its transition to the state necessary for the development of a fertilized egg. It also reduces the excitability and contractility of the muscles of the uterus and fallopian tubes, stimulates the development of terminal elements of the mammary gland.
Synthetic progesterone and its analogs have a similar effect when used as drugs.
Progesterone is prescribed for amenorrhea, anovulatory uterine bleeding, infertility, preterm pregnancy, algodismenorrhea due to hypogenitalism. Enter in the form of oil solutions intramuscularly or subcutaneously.
For bleeding associated with ovarian dysfunction, appoint 0.005-0.015 g (5-15 mg) daily for 6-8 days. If curettage of the uterine cavity has been previously cured, injections begin after 18 to 20 days. If curettage is not possible, progesterone is also administered during bleeding. When using progesterone during bleeding, it can temporarily (for 3 - 5 days) intensify; sharply anemized patients are recommended to do a blood transfusion (200 - 250 ml). With stopped bleeding, treatment should not be interrupted before 6 days. If bleeding did not stop after 6 to 8 days of treatment, further administration of progesterone is impractical.
With hypogenitalism and amenorrhea, treatment begins with the appointment of estrogenic drugs in order to cause sufficient proliferation of the endometrium. Immediately after the use of estrogen preparations is completed, progesterone is prescribed in the form of injections of 5 mg daily or 10 mg every other day for 6 to 8 days (see Estron).
With algodismenorrhea (dysmenorrhea), progesterone often reduces or eliminates pain. Treatment begins 6 to 8 days before menstruation. The drug is administered daily at 5 or 10 mg for 6 to 8 days. The course of treatment can be repeated several times. Treatment with progesterone of algodismenorrhea associated with uterine underdevelopment can be combined with the administration of estrogen drugs. Estrogens are administered at the rate of 10,000 units every other day for 2-3 weeks; then progesterone is administered for 6 days.