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Description of the medicine: Oxyprogesterone capronate (Oxyprogesteroni caproas)

OXIPROGESTERONE CAPRONATE (Oxyprogesteroni caproas).

Pregnen-4-ol-17a-dione-3, 20 capro- nate, or 17a-hydroxy-4-pregnene-3, 20-dione 17-hexanoate.

Synonyms: Hormofort, Caposten, Caprosteron, Capton, Delalutin, Depolut, Eslralutin, Hormofort, Hydroxyprogesterone caproate, Hydroxyprogesteroni caproas, Neolutin, Primolut-Depot, Progesteron-retard, Prolutin-Depot, Syngynon and others.

White or white with a slightly yellowish tinge crystalline powder. Almost nerastvorim in water, soluble in alcohol, fatty oils. 17 a - Oxyprogesterone capronate is a synthetic analog of the hormone of the yellow body - progesterone. Chemically differs from progesterone in that in position C 17 contains the residue of caproic acid. As an ether of oxyprogesterone, oxyprogesterone capronate is more stable in the body than progesterone, it acts more slowly and has a prolonged effect. After a single intramuscular injection of an oil solution of hydroxyprogesterone capronate, its effect lasts from 7 to 14 days.

On the biological properties of oxyprogesterone, capronate is similar to progesterone. Applied in pathological processes associated with malnutrition of the yellow body. Enter intramuscularly as a solution in oil.

To prevent and treat a threatening and started miscarriage, enter 0.125-0.25 g (1 - 2 ml of 12, 5% solution) once a week. Oxiprogesterone capronate is used only in the first half of pregnancy.

In amenorrhea (primary and secondary), oxyprogesterone capro- nate is administered immediately after discontinuation of the use of estrogen preparations; Enter 0.25 g once or twice.

For the treatment of dysfunctional uterine bleeding, hydroxyprogesterone capronate is less convenient than progesterone, since its effect dulls us slowly; Hydroxyprogesterone capro- nate can, however, be used to normalize the cycle. It is recommended to administer the drug at a dose of 0.0625-0.155 g (0.5-1.0 ml, 12.5% ​​solution) on the 20-22 day of the cycle.

Oxyprogasterine capronate is also used in the treatment of patients with uterine cancer, breast cancer and some other malignant tumors. Introduce a 25% solution of 3 to 4 ml intramuscularly daily or every other day for a long period (30 to 300 days).

Form release: 12, 5% (0.125 g) and 25% (0.25 g) solutions of hydroxyprogesterone caprolate in oil in ampoules containing 1 ml each.

Storage: List B. In the dark place. Ampoules are stored at a temperature not lower than 0 C. In case of precipitation in the ampoule of crystals, the ampoule is heated in a boiling bath with shaking. If the crystals disappear and the solution becomes transparent, and when cooled to + 36 - 38 C, the crystals do not fall out again, the solution is suitable for use.

Rp .: Sol. Oxyprogesteroni caproatis oleosae 12, 5% 1 ml

DtdN 10 in ampull.

S.