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Description of the medicine: Norethisteron (Norethisteronum)

NORETISTERON (Norethisteronum). 17 a-Ethynyl-17 b-oxy-4-estren-3-one, or 17 a-ethynyl-19-nortestosterone.

Synonyms: Norkolut, Ethinylnortestosterone, Aethynilnortestosteron, Anovule, Anzolan, Dianor, Fortilut, Gestest, Hormoluton, Micronor, Noralutin, Norcolut, Norethindrone, Norfor, Norgestin, Noridel, Norluten, Norlutol, Norlutol, Norlutol, Norlutol, Norlutol, Norlutol, Norlutol, Norlutol, Norlutol, Norlutol, Norlutol, Norlutol, Norlutol

The structure of norethisterone is close to ethinyl estradiol. It differs from the latter by the presence of a ketone group (instead of hydroxyl) in position C and a double bond in position 4 - 5 of ring A.

Norethisterone is a well-absorbed oral progestogen. The maximum plasma concentration is detected 1 to 2 hours after taking the drug.

Indications for use are basically the same as for other progestogens (see Progesterone, Pregnin), including dysfunctional uterine bleeding, premenstrual syndrome, menstrual cycle disorder, as well as endometriosis, cystic glandular endometrial hyperplasia, etc.

It is usually prescribed orally at a dose of 0.005-0.01 g (5-10 mg) per day (1-2 tablets).

In premenstrual syndrome and menstrual irregularities, 1 to 2 tablets are prescribed per day, starting from the 16th day of the cycle to the 25th day. With dysfunctional uterine bleeding and cystic glandular endometrial hyperplasia, 1 to 2 tablets are prescribed per day for 6 to 12 days. To prevent relapse, they are taken at the same dose in the period from the 16th to the 25th day of the cycle (usually with an estrogen preparation).

For endometriosis, 1 tablet per day is prescribed for a long time (within 6 months) from the 5th to the 25th day of the cycle or 1/2 tablet, starting from the 5th day of the cycle and gradually increasing the dose by 1/2 tablet every 2 - 3 weeks for 4 to 6 months.

In menopausal syndrome, 1 tablet is prescribed per day (continuously), if necessary, together with an estrogenic preparation, for example, ethinyl estradiol in a dose of 0.025-0.05 mg (25-50 μg per day).

In all cases, the doses of norethisterone should be selected individually depending on the nature of the disease, the effectiveness of therapy and tolerability of the drug.

When applying, nausea, allergic reactions (skin rash, etc.), paresthesia, increased fatigue, etc. are possible.

Contraindications: see Progesterone.

Release form: tablets on 0,005 g (5 mg).

Storage: in a dry, cool, dark place.