Medication Description: Norethisterone (Norethisteronum)
Norethisterone (Norethisteronum). 17 a -Etinyl 17 b -oxy-4-estren-3-one, or 17 a-ethynyl-19-nor-testosterone.
Synonyms: Norkolut, Etinilnortestosteron, Aethynilnortestosteron, Anovule, Anzela, Dentor, Formalut, Gesttest, Hormoluton, Micher, Noralutin, Norralindin, Norethindrone, Norfor, Noridel, Noridel, Norlutin, Nlthindrone
The structure of norethisterone is close to ethinyl estradiol. It differs from the latter by the presence of a ketone group (instead of hydroxyl) in position C and a double bond in position 4 - 5 of ring A.
Norethisterone is a well-absorbed oral progestogen. The maximum concentration in the blood plasma is detected 1 to 2 hours after taking the drug.
Indications for use are basically the same as for other gestagens (see Progesterone, Pregnin), including dysfunctional uterine bleeding, premenstrual syndrome, menstrual disorder, as well as endometriosis, cystic glandular hyperplasia of the endometrium, etc.
It is usually administered orally in a dose of 0.005-0.01 g (5-10 mg) per day (1-2 tablets).
In case of premenstrual syndrome and menstrual cycle disorders, 1 to 2 tablets per day are prescribed, starting from the 16th day of the cycle to the 25th day. For dysfunctional uterine bleeding and cystic glandular hyperplasia of the endometrium, 1 to 2 tablets per day are prescribed for 6 to 12 days. To prevent relapse, take the same dose in the period from the 16th to the 25th day of the cycle (usually with estrogen preparation).
In case of endometriosis, they are prescribed for a long time (for 6 months) 1 tablet per day from the 5th to the 25th day of the cycle or 1/2 tablet, starting from the 5th day of the cycle and gradually increasing the dose to 1/2 tablet every 2 - 3 weeks for 4 - 6 months.
When menopausal syndrome is prescribed, 1 tablet per day (long-term), if necessary, together with an estrogenic drug, such as ethinyl estradiol at a dose of 0.025-0.05 mg (25-50 μg per day).
In all cases, the dose of norethisterone should be adjusted individually, depending on the nature of the disease, the effectiveness of therapy and the tolerance of the drug.
With the use of possible nausea, allergic reactions (skin rash, etc.), paresthesia, fatigue, etc.
Contraindications: see Progesterone.
Product form: tablets of 0.005 g (5 mg).
Storage: in a dry, cool, dark place.