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Medication Description: Meprotan (Meprotanum)

MEPROTAN (Meprotanum).

Dicarbamate 2-methyl-2-propyl-propanediol-1, 3.

Synonyms: meprobamate, Andaxin, Aneural, Biobamat, Equanil , Gadexyl, Harmonin, Mepavlon, Meprobamatum, Meprobamate, Meproban, Meprospan, Miltown, Nephentine, Pankalma, Pertranquile, Procalmadiol, Quanil, Restenil, Sedanyl, Sedazil, Sedral, Tensonal, Tranquil, Tranquilan, Tranquiline, Tranquisan and others.

White crystalline powder. It is soluble in water, it is easy - in alcohol.

Meprotan (meprobamate) is considered to be the ancestor of tranquilizers ("small" tranquilizers). It was synthesized when searching for central muscle relaxants. The first drug of this group was 3- (ortho-toloxi) -1, 2 propandiol, or mianesin (synonyms: Mephenesin, Tolserol, etc.), however, due to the short duration of action, low efficacy when ingested and relatively high toxicity, it lost its value as a drug.

Meprotan has been found to be more active, effective when taken orally and much less toxic. Along with the muscle relaxant effect associated with the inhibition of transmission of excitation in the region of intercalary neurons of the spinal cord, thalamus and hypothalamus, it has a general sedative effect on the central nervous system, enhances the effect of sleeping pills and painkillers, has anticonvulsant activity.

MEPROTAN has no pronounced effect on the vegetative part of the nervous system; does not directly affect the cardiovascular system, respiration, smooth muscles; lowers body temperature somewhat.

Meprothan is effective as a sedative mainly for neurosis and neurosis-like conditions and has found wide application in medical practice.

Apply meprotan for neurosis and neurosis-like states, occurring with irritability, agitation, anxiety, fear, affective tension, sleep disorders, for psychoneurotic conditions associated with severe somatic diseases, as well as for diseases accompanied by increased muscle tone, for diseases of the joints with muscle spasms. .

In psychiatric practice, in acute psychotic states with productive psychopathological disorders, meprotan is ineffective.

As a sedative can have a beneficial effect in vegetative dystonia, premenstrual symptom complex, menopause, initial forms of hypertension, peptic ulcer, skin itch, etc. With sleep disorders, meprotan can be used alone and in combination with hypnotics.

In surgical practice, meprotan is used in preparation for surgical interventions to reduce the feeling of fear of the operation, to slightly reduce muscle tension.

Assign inside (after eating) tablets at a dose of 0.2 - 0.4 g per reception 2 to 3 times a day. The daily dose, if necessary, can be increased to 2 - 3 g. For insomnia take 0.2 - 0.4 - 0.6 g at bedtime.

Higher doses for adults inside: single 0.8 g daily 3 g.

For children, the drug is prescribed in smaller doses: at the age of 3–8 years — 0.1 to 0.2 g 2–3 times a day, 8–14 years — 0.2 g 2–3 times a day. The course of treatment lasts an average of 1 - 2 months.