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Description of the medicine: Meprotan (Meprotanum)

MEPROTAN (Meprotanum).

Dicarbamate 2-methyl-2-propylpropanediol-1, 3.

Synonyms: Meprobamate, Andaxin, Aneural, Biobamat, Equanil, Gadexyl, Harmonin, Mepavlon, Meprobamatum, Meprobamate, Meproban, Meprospan, Miltown, Nephentine, Pankalma, Sertilan, Tedilan, Sedilan, Tilan, Restanqual, Restanquile, Procalmadiol, Quanilan, Sedilan, Restanqual, Restanqual Tranquilan, Tranquiline, Tranquisan, etc.

White crystalline powder. Slightly soluble in water, easily in alcohol.

Meprotan (meprobamate) is considered the ancestor of tranquilizers (<small> tranquilizers). It was synthesized when searching for central muscle relaxants. The first drug in this group was 3- (ortho-toloxy) -1, 2 propanediol, or mianesin (synonyms: Mephenesin, Tolserol, etc.), however, due to its short duration, low oral efficacy, and relatively high toxicity, it lost value as a medicine.

Meprotan was more active, effective when taken orally, and significantly less toxic. Along with the muscle relaxant effect associated with inhibition of transmission of excitation in the area of ​​intercalated neurons of the spinal cord, thalamus and hypothalamus, it has a general calming effect on the central nervous system, enhances the effect of sleeping pills and painkillers, and has anticonvulsant activity.

Meprotan does not have a pronounced effect on the autonomic nervous system; does not directly affect the cardiovascular system, respiration, smooth muscles; slightly lowers body temperature.

Meprotan is effective as a sedative mainly in case of neurosis and neurosis-like conditions and has been widely used in medical practice.

Meprotan is used in case of neurosis and neurosis-like conditions that occur with irritability, agitation, anxiety, fear, affective tension, sleep disturbances, in psychoneurotic conditions associated with severe somatic diseases, as well as in diseases accompanied by increased muscle tone, in joint diseases with muscle spasms .

In psychiatric practice, in acute psychotic conditions with productive psychopathological disorders, meprotan is ineffective.

As a sedative, it can have a beneficial effect in autonomic dystonia, premenstrual symptom complex, menopause, initial forms of hypertension, gastric ulcer, skin itching, etc. In case of sleep disorders, Meprotan can be used alone and in combination with hypnotics.

In surgical practice, Meprotan is used in preparation for surgical interventions to reduce the feeling of fear of the operation, to some decrease in muscle tension.

Assign inside (after eating) in tablets at a dose of 0.2 - 0.4 g per reception 2 to 3 times a day. The daily dose, if necessary, can be increased to 2 - 3 g. For insomnia, take 0.2 - 0.4 - 0.6 g at bedtime.

Higher doses for adults inside: single 0.8 g daily 3 g.

For children, the drug is prescribed in smaller doses: at the age of 3 - 8 years old - 0.1 - 0.2 g 2 - 3 times a day, 8 - 14 years old - 0.2 g 2 - 3 times a day. The course of treatment lasts an average of 1 to 2 months.