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Description of the medicine: Amizylum (Amizylum)

AMIZIL (Amizylum). Benzylic acid 2-diethylaminoethyl ester hydrochloride.

Synonyms: Benactisin, Actozine, Amitakon, Benactina, Benactyzine, Benactyzinum, Cafron, Cevanol, Lucidil, Nervatil, Neurobenzile, Parasan, Phobex, Procalm, Suavitil, Tranquilline, etc.

White crystalline powder. Soluble in water, difficult in alcohol. Aqueous solutions during prolonged storage are hydrolyzed.

In chemical structure and pharmacological properties it is close to diphenylacetic acid esters (antispasmodic, etc.).

Amisil has versatile pharmacological activity, has a moderate antispasmodic, antihistamine, antiserotonin, local anesthetic effect.

Its most pronounced anticholinergic properties; it blocks central and peripheral cholinergic receptors. Due to the strong influence on central cholinergic systems (mainly on m-cholinergic), amisil belongs to the group of central cholinolytics.

The effect of amisil on the central nervous system is expressed in the inhibition of the convulsive and toxic effects of anticholinesterase and cholinomimetic substances, in the calming effect, increased action of barbiturates and other sleeping pills, analgesics, and local anesthetics. Amizil also inhibits the cough reflex. It blocks the effects of vagus nerve excitation (the pupils dilate, the secretion of glands decreases, the tone of smooth muscles decreases).

In neurological and psychiatric practice, amisil in connection with its calming (tranquilizing) effect is prescribed: for asthenic and neurotic reactions in patients with anxiety stress syndrome; with mild phobic and depressive states, neurodermatitis, etc. Amizil can be prescribed in combination with antipsychotics, other tranquilizers, barbiturates. In psychiatric practice, in connection with the emergence of new, more effective drugs, amisil is used to a limited extent.

As a central anticholinergic agent, amisil is effective in Parkinson's disease and other extrapyramidal disorders. The drug can prevent or reduce the effects of parkinsonism caused by phenothiazine derivatives, butyrophenones and reserpine. With simultaneous use with reserpine, the cholinomimetic effects caused by the latter are reduced.

In anesthetic practice, amizil can be used in preparing patients for anesthesia and in the postoperative period. The administration of amisil together with analgesics enhances their analgesic effect.

Like other anticholinergic drugs, amisil is also effective in diseases accompanied by spasms of smooth muscles of internal organs (peptic ulcer of the stomach and duodenum, cholecystitis, spastic colitis, etc.).

Amizil can be prescribed to patients suffering from cough.

As a mydriatic agent, amisil is convenient for diagnostic purposes: it causes a strong, but short expansion of the pupil.