Description of the medicine: Testosterone propionate (Testosteroni propionas)
TESTOSTERONE PROPIONATE (Testosteroni propionas).
Adrosten-4-ol-17 b -one-3 propionate.
Synonyms: Agovirin, Androfort, Androlin, Andronate, Homosteron, Malestron, Oreton F, Perandren, Sterandryl, Synandrone, Testolutin, Testosterone propionate, Testosteronum propionicum, Testoviron, Virormone, etc.
White crystalline powder. It is practically insoluble in water, easily soluble in alcohol, soluble in vegetable oils.
Testosterone is an endogenous male sex (adrogenic) hormone. It is produced in the male genital glands, it is necessary for the formation of the genitals and the development of secondary sexual characteristics in men. The constant production of testosterone begins during puberty and continues until the period of extinction of sexual function.
According to modern data, specialized androgen receptors exist in the body. Testosterone circulating in the blood is converted in target organs to 5-a-dihydrosterone (using the 5-a-reductase enzyme), which binds to androgen receptors and penetrates the cell nucleus. Binding in some tissues of testosterone to receptors is also possible.
For use in medical practice, synthetically obtained testosterone propionate. It has the biological and healing properties of the natural hormone, but is more slowly absorbed and more resistant in the body than testosterone. Testosterone propionate is used parenterally; when taken orally, it is ineffective (rapidly destroyed in the liver).
In addition to the specific androgenic effect, testosterone, like all androgens, has an effect on other functions and systems of the body, in particular, on nitrogen and phosphorus metabolism. It has an anabolic effect and can be considered as an endogenous anabolic hormone. The lack of testosterone in the body (with insufficient sexual development, after castration, etc.) is usually accompanied by a violation of protein anabolism, atrophy of skeletal muscles and increased deposition in the subcutaneous tissue and internal organs of adipose tissue. Substitution of testosterone preparations can have a therapeutic effect with these changes. The anabolic effect of testosterone is also manifested in various pathological conditions, accompanied by increased protein breakdown (chronic infectious diseases, malnutrition, surgical interventions, severe injuries, etc.) and impaired calcium and phosphorus metabolism (osteoporosis).
The widespread use of testosterone as an anabolic agent is prevented by its strong androgenic effect.
Currently, preparations are obtained that are close in chemical structure to testosterone, but have a more selective anabolic effect.
Testosterone propionate is prescribed mainly for men with sexual underdevelopment, functional disorders in the reproductive system, menopause, with acromegaly.