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Medication Description: Testosterone Propionate (Testosteroni propionas)

TESTOSTERONE PROPIONAT (Testosteroni propionas).

Adrosten-4-ol-17 b-it-3 propionate.

Synonyms: Agovirin, Androfort, Androlin, Andronate, Homosteron, Malestron, Oreton F, Perandren, Sterandryl, Synandrone, Testolutin, Testosterone propionate, Testosteronum propionicum, Testoviron, Virormone, etc.

White crystalline powder. Practically insoluble in water, easily soluble in alcohol, soluble in vegetable oils.

Testosterone is an endogenous male sex hormone (adrogenic) hormone. It is produced in the male gonads, it is necessary for the formation of genital organs and the development of secondary sexual characteristics in men. Permanent testosterone production begins during puberty and lasts until the period of extinction of sexual function.

According to modern data, there are specialized androgen receptors in the body. Testosterone circulating in the blood is transformed in target organs into 5 - a - dihydrosterone (with the help of the enzyme 5 - a reductase), which binds to androgen receptors and penetrates into the cell nucleus. It is possible and binding in some tissues of testosterone with receptors.

For use in medical practice, testosterone propionate is obtained synthetically. It has the biological and healing properties of a natural hormone, but is absorbed more slowly and is more stable in the body than testosterone. Testosterone propionate is used parenterally; when taken orally, it is ineffective (quickly destroyed in the liver).

In addition to the specific androgenic action, testosterone, like all androgens, has an impact on other functions and systems of the body, in particular, acts on nitrogen and phosphorus metabolism. It has an anabolic effect and can be considered as an endogenous anabolic hormone. Lack of testosterone in the body (with insufficient sexual development, after castration, etc.) is usually accompanied by a violation of protein anabolism, atrophy of skeletal muscles and increased deposits in the subcutaneous tissue and internal organs of adipose tissue. Substitution of testosterone may have a therapeutic effect on these changes. The anabolic effect of testosterone is also manifested in various pathological conditions, accompanied by increased protein breakdown (chronic infectious diseases, depletion, surgery, severe injuries, etc.) and impaired calcium and phosphorus metabolism (osteoporosis).

The widespread use of testosterone as an anabolic agent is impeded by its strong androgenic effect.

Currently, drugs have been obtained that are similar in chemical structure to testosterone, but have a more selective anabolic effect.

Testosterone propionate is prescribed mainly to men with sexual underdevelopment, functional disorders in the reproductive system, menopausal syndrome, and acromegaly.