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Description of the medicine: Methyltestosterone (Methyltestosteronum)

METHYL TESTOSTERONE (Methyltestosteronum). 17 a-Methylandrosten-4-ol-17 b -one-3.

Synonyms: Androral, Glosso-Sterandryl, Hormale, Madiol, Malogen, Metandren, Methyltestosterone, Oraviron, Oreton M, Stenendiol, Testoral, Virormoneoral

White crystalline powder; odorless and tasteless. Easily soluble in alcohol, practically insoluble in water, slightly soluble in vegetable oils.

It is a synthetic analogue of testosterone. It has biological and therapeutic properties of the natural hormone and, like it, has a stimulating effect on the development of male genital organs and secondary sexual characteristics.

Methyltestosterone is not destroyed by enzymes of the gastrointestinal tract and remains active when taken orally. For a greater effect, however, it is recommended not to swallow the tablet, but to hold it in the oral cavity (under the tongue) until it is completely resorbed.

Methyltestosterone is a strong androgen, however, compared with testosterone propionate is less active; when absorbed through the oral mucosa, it is about 3-4 times inferior in activity to testosterone to propionate injected into the muscles.

In case of indications for intensive therapy with male sex hormones, it is preferable to prescribe injections of testosterone propionate or testenate.

Methyltestosterone is prescribed for men with delayed sexual development and sexual dysfunction, with menopause.

With primary eunuchoidism and hypogenitalism due to congenital maldevelopment of the sex glands or their surgical removal, 0.02-0.03 g of the drug (sometimes more) per day is prescribed.

In moderate forms of hypogenitalism, doses of 0.02-0.025 g (20-25 mg) daily or every other day are sufficient. Treatment is carried out for a long time, depending on the severity of the disease and the effectiveness of the treatment. For the treatment of impotence due to functional insufficiency of the gonads, overwork and nervous exhaustion, 0.01-0.02 g per day is prescribed. With menopausal syndrome, they are taken orally at 0.005-0.015 g for 1 to 2 months, with prostate adenoma in the initial stage, at 0.02-0.03 g per day for 1 to 2 months; treatment is repeated depending on the course of the process. Methyltestosterone is contraindicated in patients with prostate cancer.

With delayed sexual development, infantilism and stunted growth in children (boys) and adolescents, methyltestosterone is prescribed at 0.005-0.01 g (5-10 mg) per day; the duration of treatment depends on the effect obtained.

Sometimes methyltestosterone is prescribed (at 0.005-0.015 g per day) as a tonic (partly due to the anabolic effect) to convalescents after acute infections, injuries, surgical interventions, with early aging, etc. For this purpose, however, it is better to use anabolic steroids (see).

Methyltestosterone is sometimes used in the treatment of angina pectoris. Doses are individualized by prescribing from 0.01 - 0.02 g once a week to 0.01 g daily or every other day.