Description of the medicine: Hexenalum

HEXANAL (Hexenalum).

1,5-Dimethyl-5- (cyclohexen-1-yl) -barbiturate sodium.

Synonyms: Cyclobarbitalum solubile, Endodorm, Enhexymal natrium, Enimalum natrium, Eudorm, Evipal sodium, Evipal soluble, Evipan sodium, Hexanastab, Hexobarbitalum natricum, Hexobarital sodium, Hexobaritone soluble, Methylhexabarbital soluble, Methylhexobital, Narconat, Narcosan soluble, Noctivane, Novopan and others. .

White foamy mass. In air, under the influence of carbon dioxide decomposes. Hygroscopic.

Very easily soluble in water and alcohol, almost nerastvorim in the air. The aqueous solutions of hexenal are unstable, easily hydrolyzed, decomposed by sterilization. Solutions are prepared in aseptic conditions on isotonic sodium chloride solution or on sterile water for injection just before use. Store solutions can be no more than an hour. Only absolutely transparent solutions are suitable for use.

Hexenal has a hypnotic and narcotic effect.

Apply hexenal for intravenous anesthesia. After intravenous administration of an aqueous solution of hexenal, a narcotic effect quickly sets in, which continues after a single dose of about 30 minutes.

In plasma, the water-soluble form of the drug quickly turns into a non-ionized lipophilic form that easily penetrates the blood-brain barrier.

Due to the depressing effect on the respiratory and vasomotor centers for long-term intravenous anesthesia, hexenalum is usually not used, it is used primarily for anesthetic anesthesia in combination with nitrous oxide, fluorothane, ether or other agents used for basic anesthesia.

As an independent means for anesthesia, hexenal is used, mainly for short-term out-of-pocket operations (with a duration of no more than 15-20 minutes) and with endoscopy. Hexenal anesthesia can be combined with local anesthesia.

Enter hexenal intravenously slowly, usually at a rate of 1 ml per minute. Toxic effect (respiratory and circulatory depression) is enhanced with an increase in the rate of administration and concentration of the hexenal solution (and other barbiturates). For anesthesia, usually 1 - 2% solution of hexenal is used (in some cases, 2.5 - 5% solution). Initially, 1 to 2 ml is administered and, in the absence of side effects during 30-40, an additional amount of solution is administered. The total dose, depending on the type of intervention, the general condition of the patient, etc., is 0.5 to 0.7 g of the drug (8 to 10 mg / kg).

In weakened patients, in patients with cardiovascular diseases and in children, 1% solution is used.

As a drug that activates vagal reactions less than thiobarbiturates (thiopenanthal sodium), hexenal is often used for anesthesia in bronchoscopy. Enter a vein (within 2 - 3 minutes) 1 - 2% solution at the rate of 400 - 600 mg.

The highest single (the same daily) dose of hexenal for adults in a vein is 1 g.

Before anesthesia with hexenal, the patient is administered atropine (or metacin) to prevent side effects associated with the excitation of the vagus nerve.