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Description of the medicine: Methylandrostenediol (Methylandrostendiolum)

METHYLANDROSTENDIOL (Methylandrostendiolum). 17 a - Methylandrosten-5-diol-3 b, 17.

Synonyms: Anadiol, Androdiol, Anormon, Diandrin, Diolostene, Masdiol, Mestendiol, Metandiol, Metandriol, Metasteron, Methandriol, Methandriolum, Methostan, Neosteron, Notandron, Novandrol, Protandren, Stenediol, Stenosterone, Testodonol Tron.

Flavourless white crystalline powder. Almost insoluble in water, soluble in alcohol.

In chemical structure and biological properties it is close to methyltestosterone, however, it is characterized by lower androgenic activity with a relatively higher anabolic effect. In this regard, it can be used for disorders of protein metabolism, providing a relatively weak androgenic (masculinizing) effect.

It is used to enhance protein anabolism in convalescents after severe injuries, operations, infectious and other diseases, with osteoporosis, growth retardation, exhaustion, etc.

The drug can be prescribed as an anabolic agent for women, however, due to greater androgenic activity compared to other anabolic steroids (methandrostenolone, etc.), treatment should be carried out under the supervision of a gynecologist.

Accepted sublingually. Adults are prescribed at 0.025 - 0.05 g per day; children and patients with growth retardation - at the rate of 1, 0 - 1.5 mg / kg, but not more than 0.05 g (50 mg) per day. At the same time, protein-rich foods are prescribed. The course of treatment is 4 weeks; breaks between courses 2 - 4 weeks.

Highest doses for adults: single 0.025 g, daily 0.1 g.

For menopausal disorders and dysmenorrhea, 0.025-0.05 g per day is prescribed. In breast cancer, the dose is increased to 0.2-0.3 g per day with its gradual decrease to 0.1-0.075 g per day.

When methylandrostenediol is used, side effects are possible: impaired liver function with an increase in its size and jaundice, allergic reactions, in women - virilization phenomena.

The drug is contraindicated in prostate cancer, acute liver diseases. Relative contraindications: pregnancy, lactation, decompensation of carbohydrate metabolism and acidosis in diabetes.

Release form: tablets under the tongue at 0.01 and 0.025 g (10 and 25 mg).

Storage: List B. In the dark place.