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Medication Description: Thiamin (Thiaminum)

THIAMIN (Thiaminum).

VITAMIN B (Vitaminum B 1).

Synonyms: Aneurin, Anevryl, Benerva, Beneurin, Berin, Betabion, Betamine, Betaneurin, Betavitan, Betaxin, Bethiamin, Bevimin, Bevital, Bevitine, Crystovibex, Oryzanin, Thiamin, Vitaplex B1, etc.

In nature, vitamin B 1 is found in yeast, germ and shells of wheat, oats, buckwheat, as well as in bread made from plain flour.

With fine grinding, the richest in vitamin B 1 parts of the grain is removed with bran, therefore, in the highest grades of flour and bread, the content of vitamin B 1 is sharply reduced.

For medical purposes, use synthetic drugs (thiamine bromide and thiamine chloride), corresponding to natural vitamin B 1: 4-methyl-5-b -oxyethyl-N- (2-methyl-4-amino-5-methyl-pyrimidyl) -thiazolium bromide (or chloride) hydrobromide (or hydrochloride).

Thiamine bromide (Thiamini bromidum) is a white or white powder with a slightly yellowish tinge. Thiamine chloride (Thiamin chloridum) is a white crystalline powder. Both preparations have a faint yeast odor. Easily soluble in water. Solutions (pH 2, 7 - 3, 6) are sterilized at +100 'C for 30 minutes.

Preparations of vitamin B 1 (thiamine bromide and thiamine chloride) are used as specific agents for the prevention and treatment of hypo-and avitaminosis B 1.

In addition to prophylactic and therapeutic action with appropriate hypo-and avitaminosis, indications for the use of vitamin B 1 are neuritis, sciatica, neuralgia, and peripheral paralysis.

Positive results were observed in the treatment of vitamin B 1 patients with gastric ulcer and duodenal ulcer, with intestinal atony, as well as liver disease. There is evidence of the positive effects of vitamin B 1 in myocardial dystrophy, spasms of peripheral vessels (endarteritis, etc.).

In dermatological practice, vitamin B 1 is used for dermatoses of neurogenic origin, itching of various etiologies, pyoderma, eczema, psoriasis.

When analyzing the mechanism of action of vitamin B 1, it should be borne in mind that this and other vitamins are not only specific "anti-vitamin" agents. Actively influencing various functions of the body, interfering with metabolism and neuro-reflex regulation, they can cause a positive effect on various pathological processes and should therefore be regarded as pharmacotherapeutic substances in a broad sense.

Of the pharmacological features of vitamin B 1, not directly related to its vitamin properties, it deserves, in particular, attention its ability to influence the conduction of nervous excitement in synapses. Like other compounds containing Quaternary nitrogen atoms, it has ganglioblokiruyuschimi and kurarepodobnymi properties, although expressed to a moderate degree. Influencing the processes of polarization in the field of neuromuscular synapses, it can weaken the curare-like action of depolarizing muscle relaxants (dithilina, etc.).

Apply vitamin B 1 inside (after eating) and parenteral.