Description of the medicine: Thiaminum (Thiaminum)
VITAMIN B (Vitaminum B 1).
Synonyms: Aneurin, Anevryl, Benerva, Beneurin, Berin, Betabion, Betamine, Betaneurin, Betavitan, Betaxin, Bethiamin, Bevimin, Bevital, Bevitine, Crystovibex, Oryzanin, Thiamin, Vitaplex B1, etc.
In nature, vitamin B 1 is found in yeast, germ and shells of wheat, oats, buckwheat, as well as in bread made from simple flour.
In fine grinding, the most rich in vitamin B 1 parts of the grain are removed with bran, therefore, in higher grades of flour and bread, the content of vitamin B 1 is sharply reduced.
For medical purposes, synthetic preparations are used (thiamine bromide and thiamine chloride), corresponding to the natural vitamin B 1: 4-methyl-5-b-hydroxyethyl-N- (2-methyl-4-amino-5-methyl-pyrimidyl) -thiazolium bromide (or chloride) hydrobromide (or hydrochloride).
Thiamine bromide (Thiamini bromidum) - powder, white or white with a slightly yellowish tint. Thiamine chloride (Thiamini chloridum) is a white crystalline powder. Both drugs have a faint characteristic odor of yeast. Easily soluble in water. Solutions (pH 2, 7 - 3, 6) are sterilized at +100 ° C for 30 minutes.
Vitamin B 1 preparations (thiamine bromide and thiamine chloride) are used as specific agents for the prevention and treatment of hypo- and vitamin deficiency B 1.
In addition to the preventive and therapeutic effect with appropriate hypo- and vitamin deficiency, indications for the use of vitamin B 1 are neuritis, sciatica, neuralgia, peripheral paralysis.
Positive results were noted in the treatment with vitamin B 1 in patients with peptic ulcer of the stomach and duodenum, with atony of the intestine, as well as with liver diseases. There is evidence of a positive effect of vitamin B 1 in myocardial dystrophy, peripheral vascular spasms (endarteritis, etc.).
In dermatological practice, vitamin B 1 is used for dermatoses of neurogenic origin, pruritus of various etiologies, pyoderma, eczema, psoriasis.
When analyzing the mechanism of action of vitamin B 1, it should be borne in mind that this and other vitamins are not only specific "anti-vitamin" agents. Actively influencing various functions of the body, interfering with the metabolism and neuro-reflex regulation, they can cause a positive effect in various pathological processes and therefore should be considered as pharmacotherapeutic substances in the broad sense.
Of the pharmacological characteristics of vitamin B 1, not directly related to its vitamin properties, deserves, in particular, its ability to influence the conduct of nervous excitation in synapses. Like other compounds containing quaternary nitrogen atoms, it has ganglion-blocking and curariform properties, although to a moderate extent. Influencing the processes of polarization in the region of neuromuscular synapses, it can weaken the curariform effect of depolarizing muscle relaxants (ditilin, etc.).
Vitamin B 1 is administered orally (after eating) and parenterally.