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Description medications: Thiamine (Thiaminum)

Thiamine (Thiaminum).

Vitamin B (Vitaminum In 1).

Synonyms: Aneurin, Anevryl, Benerva, Beneurin , Berin, Betabion, Betamine, Betaneurin, Betavitan, Betaxin, Bethiamin, Bevimin, Bevital, Bevitine, Crystovibex, Oryzanin, Thiamin, Vitaplex B1 and others.

In nature, vitamin B1 is contained in the yeast, wheat germ and shells, oats, buckwheat, as well as bread flour made from simple grinding.

When fine grinding of the richest in vitamin B 1 part grain with the bran removed, so the content of vitamin B 1 drastically reduced in flour and bread.

For medical purposes apply synthetic drugs (thiamine and thiamine chloride, bromide), corresponding to natural vitamin B 1: 4-methyl-5- b -oksietil-N- (2-methyl-4-amino-5-methyl-pyrimidyl) thiazole bromide (or chloride) hydrobromide salt (or hydrochloride).

Thiamine bromide (Thiamini bromidum) - white or white with a slightly yellowish white powder. Thiamine chloride (Thiamini chloridum) white crystalline powder. Both drugs have a weak characteristic smell of yeast. Easily soluble in water. The solutions (pH 2, 7 - 3 and 6) was sterilized at 100 "C for 30 min.

Preparations of vitamin B1 (thiamine and thiamine chloride bromide) is used as a specific means for the prevention and treatment of hypo-and vitamin B 1.

In addition to the preventive and therapeutic action with a corresponding hypo-and avitaminosis, testimony to the use of vitamin B 1 are neuritis, sciatica, neuralgia, peripheral paralysis.

Positive results were achieved in the treatment of vitamin B 1, patients with gastric ulcer and duodenal ulcers, intestinal, and liver diseases. There is a positive effect of vitamin B 1 with myocardial dystrophy, peripheral vascular spasm (endarteritis, etc.).

In dermatological practice, vitamin B 1 used in dermatoses of neurogenic origin, itch of various etiologies, pyoderma, eczema, psoriasis.

In the analysis of the mechanism of action of vitamin B 1, it should be noted that this and other vitamins are not only specific "antivitaminoznymi" means. Actively influencing various body functions by interfering with the metabolism and regulation of nervous reflex, they can cause various beneficial effects in disease processes and therefore must be considered as a pharmacological agent in a broad sense.

From the pharmacological characteristics of vitamin B 1, not directly related to its vitamin properties, deserves, in particular, attention to its ability to influence the conduct of neural excitation in the synapses. As other compounds containing quaternary nitrogen atoms, and it possesses ganglioblokiruyuschimi kurarepodobnymi properties, although moderately severe. By influencing the polarization processes in the field of neuromuscular synapses, it could weaken kurarepodobnoe effect of depolarizing muscle relaxants (ditilina et al.).

Apply vitamin B 1 inside (after eating) and parenteral.