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Description of the medicine: Flavinatum (Flavinatum)

Flavinatum (Flavinatum).

P 1 - (Riboflavin-5 ') - P 2 - (adenosine-5') - disodium phosphate.

A yellow-orange crystalline powder of bitter taste. Hygroscopic.

Unstable in the light and at elevated temperatures. Easily soluble in water, practically insoluble in alcohol.

Flavinate (flavin adenine nucleucleotide; FAD) is a coenzyme that is formed in the body from riboflavin (when it is phosphorylated under the influence of flavokinase contained in the intestinal mucosa, and further biotransformation catalyzed by pyrophosphorylase with the participation of AMP). Flavinadenine nucleotide, binding to a specific protein, forms enzymes involved in redox processes, the metabolism of amino acids, lipids and carbohydrates (See Phosphaden).

For use as a medicine, the disodium salt of flavin adenine nucleotide obtained synthetically and named "Flavinate". This is a lyophilized dry porous mass of yellow-orange color; unstable to light and to the effects of elevated temperature; soluble in water; pH of the solution (0.002 g in 1 ml of water) 6, 3 - 7, 5.

Abroad, a similar drug is available under the names: Adeflavin, Bisflavin, Flavinin, Flavitan, etc.

Flavinate is used for hypo- and vitamin deficiency B 2, especially if there is no effect from the use of riboflavin inside. Unlike riboflavin, flavinate can be administered parenterally; it is effective in case of malabsorption of riboflavin in the gastrointestinal tract. It is also effective in violation of riboflavin phosphorylation.

Flavinate is used in the treatment of dystrophic changes in the retina of the eye, glaucoma, chronic diseases of the liver, pancreas, intestines, some skin diseases (pink and youthful acne, etc.), as well as diseases associated with deficiency of glucose-6-phosphate dehydrogenase, etc.

The drug is administered intramuscularly (slowly); with degenerative eye diseases - under the conjunctiva of the eyeball.

Intramuscularly usually administered to adults at 0.002 g (2 mg) 1-3 times a day. Children are administered at 0.001 - 0.002 g per day. The course of treatment lasts from 5 to 30 days or more (up to 40). If necessary, treatment courses are repeated after 6 months.

In the case of long-term therapy, flavinate is administered at 0.001-0.002 g once a day.

For injection, a flavinate solution is prepared immediately before use. The contents of one ampoule (0.002 g) are dissolved in 2 ml of water for injection.

In dystrophic processes of the retina, the eyes are injected under the conjunctiva of each eyeball with 0.3 ml of a 0.2% solution (0.6 mg of the drug) every other day; on a course of 10 to 15 injections. Courses can be repeated after 8 - 12 months.

In complex therapy for glaucoma, they use intramuscularly at 0.002 g of the drug 1 time per day daily for 10 days.

When a headache, dizziness, prolonged lacrimation occurs in the case of subconjunctival administration of the drug, the drug is administered under the conjunctiva and transferred to intramuscular injections.