Description of the medicine: Flavinatum (Flavinatum)

FLAVINATUM.

P 1 - (Riboflavin-5 ') - P 2 - (adenosine-5') - diphosphate disodium salt.

Yellow-orange crystalline powder bitter taste. Hygroscopic.

It is unstable in light and at elevated temperature. Easily soluble in water, almost insoluble in alcohol.

Flavinate (flavinadenin nucleotide; FAD) is a coenzyme that is formed in the body from riboflavin (when it is phosphorylated under the influence of flavokinase contained in the intestinal mucosa and further biotransformation catalyzed by pyrophosphorylase with the participation of AMP). Flavinadenine nucleotide, when bound to a specific protein, forms enzymes involved in oxidation-reduction processes, the exchange of amino acids, lipids and carbohydrates (see Phosphaden).

For use as a medicine, the disodium salt of flavin adenine nucleotide is synthesized and named "Flavinate." This is a lyophilized dry porous mass of yellow-orange color; Is unstable to light and to the effect of elevated temperature; Soluble in water; The pH of the solution (0.002 g in 1 ml of water) 6, 3 - 7, 5.

Abroad a similar preparation is issued under the names: Adeflavin, Bisflavin, Flavinin, Flavitan, etc.

Apply flavinate for hypo-and avitaminosis B 2, especially if there is no effect of using riboflavin inside. In contrast to riboflavin, flavinate can be administered parenterally, it is effective in the violation of absorption of riboflavin in the gastrointestinal tract. Effective also in violation of riboflavin phosphorylation.

Flavinate is used in the treatment of dystrophic changes in the retina of the eye, glaucoma, chronic liver disease, pancreas, intestines, with some skin diseases (pink and youth acne, etc.), as well as diseases associated with deficiency of glucose 6-phosphate dehydrogenase, etc.

Enter the drug intramuscularly (slowly); With dystrophic eye diseases - under the conjunctiva of the eyeball.

Intramuscularly usually administered to adults at 0,002 g (2 mg) 1 - 3 times a day. Children are administered 0.001 to 0.002 g per day. The course of treatment lasts from 5 to 30 days or more (up to 40). If necessary, repeat treatment courses after 6 months.

In the case of long-term therapy, flavinate is administered 0.001-0.002 grams once a day.

For injections, prepare a flavinate solution immediately before use. The contents of one ampoule (0.002 g) are dissolved in 2 ml of water for injection.

In dystrophic retinal processes, the eyes are injected under the conjunctiva of each eyeball with 0.3 ml of 0.2% solution (0.6 mg of the drug) every other day; For a course of 10 to 15 injections. Courses can be repeated in 8 - 12 months.

In complex therapy, glaucoma is used intramuscularly at 0,002 g of the drug once a day every day for 10 days.

When a headache, dizziness, and prolonged lacrimation appear in the case of subconjunctival administration, discontinue the administration of the drug for conjunctivitis and switch to intramuscular injection.