Medication Description: Cyanocobalamin (Cyanocobalaminum)
VITAMIN B 12 (Vitaminum B 12).
Co a - [a - (5, 6-Dimethylbenzimidazolyl) -Co b-bobamidcyanide, or a- (5, 6dimethyl-benzimidazolyl) -cobamidane.
Synonyms: Actamin B12, Almeret, Anacobin, Antinem, Antipernicin, Arcavit B12, Bedodec, Bedoxyl, Bedumil, Berubigen, Biopar, Catavin, Cobetab, Cobavite, Cobione, Curibin, Cycobemin, Cycoplex, Cytacon, Cytamen, Cytocris, Curibin, Cycobemin, Cycoplex, Cytacon, Cytomen, Cytobe, Cutocin, Cytobemin, Cytobemin , Distivit, Dobetin, Dociton, Dodecavit, Emobione, Grisevit, Hepagon, Lentovit, Megalovel, Novivit, Pernapar, Redamin, Reticulogen, Rubavit, Rubivitan, Rubramin, Vibicon, etc.
Crystalline powder of dark red, odorless. Hygroscopic. It is difficult to dissolve in water; solutions have a red (or pink) color. Sterilize the solutions at a temperature of + 100 ° C for 30 minutes. With prolonged autoclaving, the vitamin is destroyed. Oxidizing reducing substances (for example, ascorbic acid) and heavy metal salts contribute to the inactivation of the vitamin. Microflora rapidly absorbs vitamin B 12, so solutions must be stored under aseptic conditions.
A characteristic chemical feature of the cyanocobalamin molecule is the presence of a cobalt atom and a cyano group in it, forming a coordination complex.
Vitamin B 12 (cyanocobalamin) animal tissues are not formed. Its synthesis in nature is carried out by microorganisms, mainly bacteria, actinomycetes, blue-green algae. In humans and animals, it is synthesized by intestinal microflora, from where it enters the organs, accumulating in the greatest amounts in the kidneys, liver, intestinal wall. Synthesis in the intestine of the body's need for vitamin B 12 is not fully met; additional quantities come from animal products. Vitamin B 12 is contained in varying amounts in medicinal preparations derived from the liver of animals (see Vitohepat).
In the body, cyanocobalamin is converted into a coenzyme form of adenosylcobalamin, or cobamamide (see), which is the active form of vitamin B 12.
Cyanocobalamin has a high biological activity. It is a growth factor, it is necessary for normal blood formation and maturation of red blood cells; participates in the synthesis of labile methyl groups and in the formation of choline, methionine, creatine, nucleic acids; contributes to the accumulation in erythrocytes of compounds containing sulfhydryl groups. It has a beneficial effect on the function of the liver and nervous system.
Cyanocobalamin activates the blood coagulation system; in high doses causes an increase in thromboplastic activity and prothrombin activity.
It activates the metabolism of carbohydrates and lipids. With atherosclerosis, it lowers the blood cholesterol level somewhat, increases the lecithin-cholesterol index.
Cyanocobalamin has a pronounced therapeutic effect in Addison's disease - Birmer, agastric anemia (after gastrectomy), with anemia due to polyposis and syphilis of the stomach, with anemia accompanying enterocolitis, as well as with other pernicious-like anemias, including invasion caused by a wide variety of invasions, and also with other pernicious-like anemias, including invasive anemia, including widespread invasive anemia, as well as other pernicious anemia, including invasive anemia, including widespread invasion during pregnancy, sprue, etc.