Description of the medicine: Nicotinamide (Nicotinamid)
Amide of nicotinic acid.
Synonyms: Aminicotin, Benicot, Bepella, Endobion, Niacevit, Niacinamid, Nicamid, Nicofort, Nicotol, Nicovit, Pelmin, etc.
White crystalline powder. Easily soluble in water and alcohol. Aqueous solutions (pH 5, 0 - 7, 0) are sterilized at +100 ° C for 30 minutes.
In structure and action, it is close to nicotinic acid and, along with it, is considered as vitamin PP.
Due to the neutral reaction of the solutions, nicotinamide does not cause a local reaction during injection. Nicotinamide does not have a pronounced vasodilating effect, and when it is used, there is no reddening of the skin and a feeling of a rush of blood to the head, which are often found when using nicotinic acid.
Indications for use and doses are basically the same as for nicotinic acid (pellagra, gastritis with low acidity, chronic colitis, hepatitis, cirrhosis of the liver, etc.). As a vasodilator, nicotinamide, however, is not used.
Nicotinamide is administered orally and parenterally.
Prophylactically prescribed for adults at 0.015-0.025 g, children at 0.005-0.01 g 1 to 2 times a day.
With pellagra, adults are prescribed orally at 0.05-0.1 g 3-4 times a day, for children 0.01-0.05 g 2-3 times a day for 15-20 days, with other diseases 0, 02 - 0.05 g for adults and 0.005 - 0.01 g for children 2-3 times a day.
Intravenously, intramuscularly or subcutaneously, 1 to 2 ml of 1% is administered; 2, 5% or 5% solution 1 - 2 times a day.
Method of release: powder; tablets of 0.015 g (for preventive purposes) and 0.005 and 0.025 g (for therapeutic purposes); 1% solution in ampoules of 1 ml, 2.5% solution in ampoules of 1 and 2 ml.
Storage: List B. In a tightly sealed container that protects from the action of light; ampoules - in a dark place.
Rp.: Tab. Nicotinamidi 0.025 N. 50
DS 1 tablet 2 times a day
Rp.: Sol. Nicotinamidi 2, 5% 1 ml
DtdN 20 in ampull.
S. 1 ml intramuscularly 1 to 2 times a day
Nicotinamide is part of a number of multivitamin preparations (see Aerovit, Pentovit, Heptavit, Tetravit, Complivit).