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Description of medicine: Calcium pantothenate (Calcii pantothenas)

CALCIUM PANTOTENATE (Calcii pantothenas).

Calcium salt of D (+) pantothenic acid.

Synonyms: Calcipan, Calcium pantothenicum, Calpanate, Cutivitol, Pancal, Panthoject, Pantholin, Pantotene, Pantothaxin, Pantotone, Pentavitol.

White crystalline powder. Easily soluble in water, very little in alcohol. Weakly hygroscopic. Aqueous solutions (pH 6, 5 -9, 0) are optically active; specific rotation (+25 ") - (+28 '); sterilized at +100' C for 30 minutes.

Pantothenic acid (From the Greek word "pantothen" - everywhere, everywhere. Pantothenic acid is designated by some authors as "Vitamin B 5", others - as "Vitamin Bz.") [D (+) a, g-dioxi-b, b - dimethylbutyryl-b-alanine] is widespread in nature. Its richest food sources are the liver, kidneys, egg yolk, fish roe, peas, and yeast.

In the body, pantothenic acid is part of coenzyme A, which plays an important role in the processes of acetylation and oxidation. Pantothenic acid is involved in carbohydrate and fat metabolism and in the synthesis of acetylcholine. It is found in significant quantities in the adrenal cortex and stimulates the formation of corticosteroids.

The human need for pantothenic acid is 10 to 12 mg per day. With heavy physical labor and in nursing women, it rises to 20 mg. In the human body pantothenic acid is produced in significant quantities by Escherichia coli, therefore, vitamin deficiency associated with the absence of pantothenic acid is not observed in humans. In various animals with its deficiency, pathological processes such as vitamin deficiency are noted.

As a medicine, the calcium salt of pantothenic acid (obtained synthetically) is used for various pathological conditions associated with metabolic disorders; with polyneuritis, neuralgia, paresthesia, eczema, allergic reactions (dermatitis, hay fever, etc.), trophic ulcers, burns, toxicosis of pregnant women, chronic liver diseases, chronic pancreatitis, diseases of the gastrointestinal tract of non-infectious nature (gastroduodenitis, etc.).

Improving the energy supply of myocardial contractile function and enhancing the cardiotonic effect of cardiac glycosides, calcium pantothenate increases their therapeutic effectiveness.

In surgical practice, calcium pantothenate is used to eliminate intestinal atony after surgery on the gastrointestinal tract.

Assign to reduce the toxic effects of streptomycin and other anti-TB drugs.

Recently, calcium pantothenate has been used in the complex treatment of withdrawal symptoms in patients with alcoholism.

Calcium pantothenate is administered orally, intramuscularly or intravenously.

Inside appoint adults 0.1 to 0.2 g 2 to 4 times a day; children from 1 year to 3 years - at 0.005 - 0.1 g per reception, from 3 to 14 years - 0.1 - 0.2 g per reception 2 times a day. The daily dose for adults is 0.4 - 0.8 g, for children 0.1 - 0.4 g.

In dermatological practice, they are used in large doses: in adults, 1.5 g per day, in children 0.1 to 0.3 g 2 to 3 times a day.