Description of the medicine: Calcium pantothenate (Calcii pantothenas)

CALCIUM PANTOTENATE (Calcii pantothenas).

Calcium salt of D (+) pantothenic acid.

Synonyms: Calcipan, Calcium pantothenicum, Calpanate, Cutivitol, Pancal, Panthoject, Pantholin, Pantotene, Pantothaxin, Pantotone, Pentavitol.

White fine crystalline powder. The easily soluble in water, very little - in alcohol. It is weakly hygroscopic. Aqueous solutions (pH 6, 5 -9, 0) are optically active; Specific rotation (+25 ") - (+28 '), sterilized at +100' C for 30 minutes.

Pantothenic acid (from the Greek word "pantothen" is everywhere, pantothenic acid is designated by some authors as "vitamin B 5", others as "vitamin B".) [D (+) a, g -dioxy-b, b - Dimethylbutyryl-b-alanine] is widely distributed in nature. The richest food sources are liver, kidney, egg yolk, fish caviar, peas, yeast.

In the body pantothenic acid is a part of coenzyme A, which plays an important role in the processes of acetylation and oxidation. Pantothenic acid is involved in carbohydrate and fat metabolism and in the synthesis of acetylcholine. It is contained in significant amounts in the adrenal cortex and stimulates the formation of corticosteroids.

The human need for pantothenic acid is 10 - 12 mg per day. In severe physical labor and in nursing women, it rises to 20 mg. In humans, pantothenic acid is produced in significant amounts by the intestinal rod, therefore, avitaminosis, associated with the absence of pantothenic acid, is not observed in humans. In various animals, with its deficiency, pathological processes such as avitaminosis are noted.

As a medicine, the calcium salt of pantothenic acid (obtained synthetically) is used for various pathological conditions associated with metabolic disorders; At polyneuritis, neuralgias, paresthesias, eczema, allergic reactions (dermatitis, hay fever, etc.), trophic ulcers, burns, toxicosis of pregnant women, chronic liver diseases, chronic pancreatitis, diseases of the gastrointestinal tract of non-infectious nature (gastroduodenitis, etc.).

Improving the energy supply of contractile function of the myocardium and enhancing the cardiotonic effect of cardiac glycosides, calcium pantothenate increases their therapeutic effectiveness.

In surgical practice, calcium pantothenate is used to eliminate intestinal atony after surgery on the gastrointestinal tract.

Assign to reduce the toxic effects of streptomycin and other anti-tuberculosis drugs.

Recently, calcium pantothenate has been used in the complex treatment of withdrawal syndrome in patients with alcoholism.

Enter the calcium pantothenate inside, intramuscularly or intravenously.

Inside appoint adults to 0.1 - 0.2 g 2 - 4 times a day; Children from 1 year to 3 years - 0,005 - 0,1 g per reception, from 3 to 14 years - 0,1 - 0,2 g for taking 2 times a day. The daily dose for adults is 0,4 - 0,8 g, for children 0,1 - 0,4 g.

In dermatological practice, they are used in large doses: in adults 1-5 g per day, in children 0.1-0.3 g 2-3 times a day.