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Description of the medicine: Tocopherol acetate (Tocopheroli acetas)

TOCOPHEROL ACETATE (Tocopheroli acetas). 6-Acetoxy-2-methyl-2- (4, 8, 12-trimethyl-tridecyl) -chroman.

Synonyms: Vitamin E acetate, a-Tocopherol acetate, Almefrol, Egevit, Esol, Evitaminum, Evitan, Fertiligen, Gonavil, Phytoferol, Profecundin, Tocofyn, a-Tocopherol, Tocovit, Vitaplex E, etc.

Light yellow, clear, viscous, oily liquid with a faint odor. It oxidizes and darkens in the light.

Tocopherol acetate is a synthetic preparation of vitamin E. Under the name "Vitamin E" a number of compounds (tocopherols) are known that are similar in chemical nature and biological effect. The most active of these is α-tocopherol.

Tocopherols are found in the green parts of plants, especially in young sprouts of cereals; vegetable oils are rich in tocopherols (sunflower, cottonseed, corn, peanut, soybean, sea buckthorn). A certain amount of them is also found in meat, fat, eggs, milk.

Vitamin E is a natural antioxidant (antioxidant). It protects various substances from oxidative changes. Participates in the biosynthesis of heme and proteins, cell proliferation, tissue respiration and other major processes of cellular metabolism.

An important role is played by vitamin E in the activity of the body. In animals deprived of vitamin E, degenerative changes in skeletal muscles and heart muscle were detected, increased permeability and fragility of capillaries, degeneration of the epithelium of the seminiferous tubules, and testicles. In embryos, hemorrhages occur, their intrauterine death sets in. Degenerative changes in nerve cells and damage to the liver parenchyma are also observed. Hemolytic jaundice of newborns, steatorrhea, malabsorption syndrome, etc. can be associated with vitamin E deficiency.

Recently, the antioxidant properties of tocopherol have attracted close attention (See. Antihypoxants and antioxidants.).

Dibunolum preparations (see), emoksipin (see) also possess antioxidant properties and a number of other medicines. These drugs inhibit lipid peroxidation (LPO). Due to the fact that during a number of pathological processes, lipid oxidation is activated and lipid peroxidation products accumulate in organs and tissues (including blood plasma), antioxidants have been used in the complex treatment of various diseases. Tocopherol acetate has been especially widely used.

Basically, tocopherol acetate is used as a medicine for muscular dystrophies, dermatomyositis, amotrophic lateral sclerosis, menstrual irregularities, the threat of abortion, and malfunction of the gonads in men. There is evidence of the effectiveness of tocopherol in some dermatoses, psoriasis, and spasms of peripheral vessels.

In pediatric practice, tocopherol is effective in scleroderma, malnutrition, and other diseases.