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Medication Description: Tocopherol Acetate (Tocopheroli acetas)

TOCOFEROLA ACETATE (Tocopheroli acetas). 6-Acetoxy-2-methyl-2- (4, 8, 12-trimethyl-tridecyl) -chroman.

Synonyms: Vitamin E acetate, a-Tocopherol acetate, Almefrol, Egevit, Esol, Evitaminum, Evitan, Fertiligen, Gonavil, Phytoferol, Profecundin, Tocofyn, a-Tocopherol, Tocovit, Vitaplex E, etc.

Light yellow transparent viscous oily liquid with a faint odor. It oxidizes and darkens in the light.

Tocopherol acetate is a synthetic preparation of vitamin E. Under the name "Vitamin E" is known a number of compounds (tocopherols), similar in chemical nature and biological action. The most active of these is a-tocopherol.

Tocopherols are found in the green parts of plants, especially in young shoots of cereals; vegetable oils (sunflower, cottonseed, corn, peanut, soybean, sea buckthorn) are rich in tocopherols. Some of them are also found in meat, fat, eggs, milk.

Vitamin E is a natural antioxidant (antioxidant). It protects various substances from oxidative changes. Participates in the biosynthesis of heme and proteins, cell proliferation, tissue respiration and other important processes of cellular metabolism.

An important role is played by vitamin E in the body. In animals devoid of vitamin E, degenerative changes were found in skeletal muscle and heart muscle, an increase in capillary permeability and fragility, degeneration of the epithelium of the seminiferous tubules, and testes were noted. Embryos develop hemorrhages, their intrauterine death occurs. There are also degenerative changes in the nerve cells and damage to the liver parenchyma. Hemolytic jaundice of newborns, steatorrhea, malabsorption syndrome, etc. may be associated with vitamin E deficiency.

Recently, the antioxidant properties of tocopherol have attracted considerable attention. (See. Antihypoxants and antioxidants.).

Antioxidant properties are also drugs dibunol (see), emoxipin (see) and a number of other drugs. These funds inhibit lipid peroxidation (LPO). Due to the fact that in a number of pathological processes, activation of lipid oxidation and accumulation of LPO products occurs in organs and tissues (including blood plasma), antioxidants have been used in the treatment of various diseases. Especially widely used tocopherol acetate.

Basically, tocopherol acetate is used as a drug for muscular dystrophies, dermatomyositis, aromotrophic lateral sclerosis, menstrual disorders, threatened abortion, dysfunction of the sex glands in men. There is evidence of the effectiveness of tocopherol in some dermatoses, psoriasis, and spasms of peripheral vessels.

In pediatric practice, tocopherol is effective for scleroderma, hypotrophy and other diseases.