Description of the medicine: Chymopsinum (Chymopsinum)

HIMOPSIN (Chymopsinum).

Chymopsin (or amorphous chymotrypsin) is obtained from the pancreas of slaughter cattle. Contains a mixture of a-chymotrypsin and trypsin.

Brilliant flakes or powder white or white with a weak yellowish hue of color. Easily soluble in water and isotonic sodium chloride solution; PH 0.2% aqueous solution 4, 5 - 6, 5. The aqueous solution should be colorless, transparent or with weak opalescence, but not containing a precipitate. Solutions are unstable, at high temperatures quickly inactivated, at a temperature of +2 to +5 C can be stored for a day.

On biological properties, chymopsin is similar to a-chymotrypsin and trypsin, but less purified and allowed only for topical application (on purulent wound surfaces and for inhalation); It is not possible to apply parenterally.

In the treatment of purulent wounds and decubituses, 0.025-0.05 g (25-50 mg) of chymopsin in 10-50 ml of 0.25% solution of novocaine is dissolved; The solution is moistened with sterile wipes, which are applied to the wound surface for 8 hours or more (depending on the thickness of the purulent necrotic layer). At the same time, it is advisable to use antibiotics.

With third-degree burns, untranslated necrotic tissues are previously removed, then a thin layer of chemopsin is applied (as a powder) and covered with a dressing dipped in an isotonic solution of sodium chloride or in a 0.25% solution of novocaine in borate buffer (pH 8, 6). A moisture-proof bandage is applied from above. Bandages are changed every other day. Before each next application, easily detachable areas of necrosis are removed. A 0.5-1% solution of chymopsin can also be used. When wounds covered with a thick scab, cut the scab so that the drug penetrated into the depths of the tissues.

Local application of chymopsin can be combined with the introduction of scrap crystal chymotrypsin (0.02 g in 20 ml of 0.25% solution of novocaine).

When treating ulcers of the cornea and keratitis, use trays with 0.2% solution or drops (0.25%) 3 to 4 times a day for 1 to 2 to 3 days.

For inhalations, with inflammatory diseases of the upper respiratory tract and lungs, dissolve 25 to 30 mg of the drug in 5 ml of sterile isotonic sodium chloride solution or distilled water. The solution can also be administered via a bronchoscope or an endotracheal probe. Inhalation is repeated 1 to 2 times a day; The duration of treatment depends on the nature and course of the disease. After inhalation, rinse your mouth and rinse your nose. In the next few hours after inhalation, the patient should carefully cough up phlegm or it should be sucked. Antibiotics and bronchodilators can be added to the solutions of chymopsin.

When using chymopsin, allergic reactions are possible, mainly due to the absorption of products of proteolysis of necrotic tissues. Therefore, before using chymopsin, the patient should be prescribed an antihistamine drug (diphenhydramine or other). After inhalation of chemopsin, sometimes there is hoarseness of the voice, which disappears on its own.