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Description of the medicine: Ribonuclease (amorphous) (Ribonucleasum amorphum)

RIBONUCLEASE (amorphous) (Ribonucleasum amorphum).

An enzyme preparation obtained from the pancreas of cattle.

Lyophilized powder, white or creamy white. Easily soluble in water, isotonic sodium chloride solution, novocaine solution.

Ribonuclease has the specific ability to depolymerize RNA to acid-soluble mono- and oligonucleotides. The drug is able to dilute pus, mucus, viscous and thick sputum; also has anti-inflammatory properties.

In connection with the destruction of nucleic acids, ribonuclease has the ability to delay the reproduction of a number of RNA-containing viruses.

The activity of ribonuclease is determined by the biological method by the amount of acid-soluble substances released by the drug as a result of hydrolysis of ribonucleic acid under certain conditions. One unit of activity (EA) corresponds to 1 mg of the drug.

The main indications for the use of ribonuclease, possible complications, contraindications and precautions are the same as for crystalline trypsin. In addition, the drug is used (intramuscularly) for the treatment of tick-borne encephalitis (in severe forms of the disease in combination with anti-encephalitis gamma globulin). There is evidence of the effectiveness of amorphous ribonuclease in viral meningitis.

Apply topically, in the form of aerosols for inhalation, intrapleural, intramuscular. When applied topically, sprinkle the wound or ulcer surface with the powder of the drug in an amount of 0.025-0.05 g (25-50 mg) and apply napkins or tampons moistened with a solution of the drug in isotonic sodium chloride solution.

For inhalation use a fine aerosol; dose - 25 mg per procedure; the drug is dissolved in 3-4 ml of an isotonic sodium chloride solution or in a 0.5% solution of novocaine. Endobronchial injected using a laryngeal syringe or catheter, a solution containing 25 to 50 mg of the drug. The same dose is administered intrapleurally in 5-10 ml of an isotonic sodium chloride solution or 0.25% novocaine solution.

When sinusitis is injected into the maxillary (maxillary) sinus (after puncture and washing), 5-10 mg in 3-5 ml of isotonic sodium chloride solution; with otitis media, a 0.1% solution (0.5-1 ml) is instilled into the ear.

Intramuscularly injected 5 to 10 mg in 1 ml of isotonic sodium chloride solution or 0.5% novocaine solution. For a course of 2 to 10 injections, 1 to 2 injections per day. The maximum single dose with an intramuscular injection of 10 mg, with local and intracavitary administration of 50 mg.

For the treatment of tick-borne encephalitis is administered intramuscularly. Single doses for children up to 1 year 3 mg, from 2 to 3 years 5 to 8 mg (depending on body weight), from 4 to 6 years 10 to 14 mg, from 7 to 11 years 15 to 18 mg, from 12 up to 15 years 20 mg, for adults 25 - 30 mg. Injections are repeated 6 times a day at 4-hour intervals. The required amount of the drug is dissolved before injection in 2 ml of a 0.25 - 0.5% solution of novocaine.