Description of the drug: Ribonuclease (amorphous) (Ribonucleasum amorphum)

RIBONUCLEASE (amorphous) (Ribonucleasum amorphum).

Enzyme preparation, obtained from the pancreas of cattle.

Freeze-dried powder white or white with a cream color shade. Easily soluble in water, isotonic sodium chloride solution, solution of novocaine.

Ribonuclease has a specific ability to depolymerize RNA to acid-soluble mono- and oligonucleotides. The drug is able to thin pus, mucus, viscous and thick sputum; Has also anti-inflammatory properties.

In connection with the destruction of nucleic acids, ribonuclease has the ability to delay the multiplication of a number of RNA-containing viruses.

The activity of ribonuclease is determined by the biological method according to the amount of acid-soluble substances released by the drug as a result of the hydrolysis of ribonucleic acid under defined conditions. One unit of activity (EA) corresponds to 1 mg of the drug.

The main indications for the use of ribonuclease, possible complications, contraindications and precautions are the same as for trypsin crystalline. In addition, the drug is used (intramuscularly) to treat tick-borne encephalitis (in severe forms of the disease in combination with anti-encephalitic gamma-globulin). There are data on the effectiveness of amyloid ribonuclease in viral meningitis.

Apply topically, in the form of aerosols for inhalation, intrapleural, intramuscular. When topical application sprinkled wound or ulcer surface powder of the drug in an amount of 0.025-0.05 g (25-50 mg) and apply wipes or tampons moistened with the solution of the drug in isotonic sodium chloride solution.

For inhalation use fine-dispersed aerosol; A dose of 25 mg per procedure; The drug is dissolved in 3 - 4 ml of isotonic sodium chloride solution or in 0.5% solution of novocaine. Endobronchially administered with a laryngeal syringe or catheter solution containing 25 - 50 mg of the drug. Intrapleural injected the same dose in 5 - 10 ml of isotonic sodium chloride solution or 0.25% solution of novocaine.

When sinusitis is introduced into the maxillary (gaymorovu) sinus (after puncture and rinsing) 5 - 10 mg in 3 - 5 ml isotonic sodium chloride solution; When otitis is instilled in a 0.1% solution (0.5-1 ml) in the ear.

Intramuscularly administered 5 to 10 mg in 1 ml of isotonic sodium chloride solution or 0.5% solution of novocaine. On the course of 2 - 10 injections of 1 - 2 injections per day. The maximum single dose for intramuscular injection of 10 mg, with local and intracavitary injection of 50 mg.

To treat tick-borne encephalitis is administered intramuscularly. Single doses for children under 1 year 3 mg, 2 to 3 years 5 to 8 mg (depending on body weight), 4 to 6 years 10 to 14 mg, 7 to 11 years 15 to 18 mg, from 12 Up to 15 years 20 mg, for adults 25 - 30 mg. Injections are repeated 6 times a day at 4-hour intervals. The required amount of the drug is dissolved before injection in 2 ml of 0.25-0.5% solution of novocaine.