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Medication Description: Ribonuclease (amorphous) (Ribonucleasum amorphum)

RIBONUCLEASIS (amorphous) (Ribonucleasum amorphum).

Enzyme preparation derived from the pancreas of cattle.

Lyophilized powder white or white with a cream shade of color. Easily soluble in water, isotonic sodium chloride solution, novocaine solution.

Ribonuclease has the specific ability to depolymerize RNA to acid-soluble mono- and oligonucleotides. The drug is able to liquefy pus, mucus, viscous and thick sputum; also has anti-inflammatory properties.

In connection with the destruction of nucleic acids, ribonuclease has the ability to delay the reproduction of a number of RNA-containing viruses.

The ribonuclease activity is determined by a biological method according to the amount of acid-soluble substances released by the preparation as a result of the hydrolysis of ribonucleic acid under certain conditions. One unit of activity (EA) corresponds to 1 mg of the drug.

The main indications for ribonuclease, possible complications, contraindications and precautions are the same as for crystalline trypsin. In addition, the drug is used (intramuscularly) for the treatment of tick-borne encephalitis (in severe forms of the disease in combination with anti-encephalitic gamma globulin). There is evidence of the effectiveness of amorphous ribonuclease in viral meningitis.

Applied topically, in the form of aerosols for inhalation, intrapleural, intramuscularly. When applied topically, sprinkle the wound or ulcer surface with the preparation powder in an amount of 0.025-0.05 g (25-50 mg) and apply napkins or tampons moistened with a solution of the preparation in isotonic sodium chloride solution.

For inhalation use fine aerosol; dose - 25 mg per procedure; the drug is dissolved in 3 to 4 ml of isotonic sodium chloride solution or in a 0.5% solution of novocaine. Endobronchial solution is administered with a laryngeal syringe or catheter solution containing 25-50 mg of the drug. Intrapleurally injected the same dose in 5 - 10 ml of isotonic sodium chloride solution or 0.25% novocaine solution.

When sinusitis is introduced into the maxillary (maxillary) sinus (after puncture and washing) 5-10 mg in 3-5 ml isotonic sodium chloride solution; with otitis, a 0.1% solution (0.5-1 ml) is instilled into the ear.

Intramuscularly administered 5-10 mg in 1 ml of isotonic sodium chloride solution or 0.5% solution of novocaine. In the course of 2 - 10 injections, 1 - 2 injections per day. The maximum single dose for intramuscular injection of 10 mg, with local and intracavitary injection of 50 mg.

For the treatment of tick-borne encephalitis is administered intramuscularly. Single doses for children up to 1 year 3 mg, from 2 to 3 years 5 to 8 mg (depending on body weight), from 4 to 6 years 10 to 14 mg, from 7 to 11 years 15 to 18 mg, from 12 up to 15 years 20 mg, for adults 25-30 mg. Injections are repeated 6 times a day with 4-hour intervals. The required amount of the drug is dissolved before injection in 2 ml of 0.25 - 0.5% solution of novocaine.